Abstract: The present invention relates to a method of controlling the flow of a fluid in a tube (11) of an infusion pump (1), in particular for chronomodulated administration of anticancer drugs. The inventors found that the actual drug flow exiting such a pump has unexpected time delays and/or drug delivery spikes. The proposed method comprises an estimation of the temporal evolution of the concentration of drug or other substances at an exit end (E11) of said tube (11) as a function of a size of said tube (11). Typically, the size of the tube (11) may be its length (L11) and said concentration may be estimated according to a transport equation.

Abstract: A therapeutic system, in particular to a medical injection system consisting of an external arrangement (12) includes a data receiver (20) and a data processing device (26) and of an injection arrangement (10) which is implantable into a living body and includes an injection device, a sensor of the living body parameter, a data transmitter (18) and a control and adjusting device (24) which determines a parameter measuring or data transmission condition such as a frequency of measurements for adapting the operation thereof to a patient actual state. The system is used for cancer and other disease chronotherapy.