Abstract: A blade of an axial compressor comprising: an airfoil is disclosed that has a leading edge and a root; a platform attached to the root of the airfoil; a dovetail attached to a side of the platform opposite to the airfoil; a neck of the dovetail adjacent the platform, and a slot in the neck and generally parallel to the platform, and the slot extends from a front of the neck to position in the neck beyond a line formed by the leading edge of the blade.

Abstract: Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.

Abstract: A blade of an turbomachine having an airfoil with a leading edge and a root; a base attached to the root of the airfoil; a dovetail portion of the base engageable with disk; a slot in the base generally parallel to a face of the base extending between opposite sides of the base, and a vibration adsorbing insert snuggly fitted into the slot.

Abstract: Aerodynamically efficient air flow management in axial flow-turbines is provided by utilizing a variable stagger and camber airfoil. In an exemplary embodiment of the invention, this is accomplished by providing a two-piece airfoil including a strut and a flap, each of which is mounted to articulate about a common, radially oriented axis. The strut and flap are respectively positioned by a strut gear and a flap gear, located at the radial end of the airfoil and, in an exemplary embodiment, are driven by a stepped synchronizing ring.

Abstract: Blades of increased blade angle may be retrofitted onto existing compressor rotor wheels as replacement blades whereby higher performance and efficiency without replacing the rotor wheel may be achieved. The base attachments of replacement blades are provided with lateral extensions or flanges and the rim of the compressor wheel is provided with recesses straddling the grooves to accommodate the flanges. The leading edge of the replacement blade is positioned circumferentially for support only by the platform extension thereby limiting the mean and vibratory stresses in the leading edge of the airfoil and maximizing damage tolerance.

Abstract: A combustor for oxidizing a combustion fuel and pre-heating one or more reactants for fuel reforming. The combustor includes an elongated housing having an inlet for receiving a combustion fuel and an outlet for exhausting combustion products. The elongated housing further includes a cylindrical side wall, a bottom wall, and a top wall. Inert particles are disposed within the housing adjacent the inlet. A combustion catalyst bed is disposed within the housing above the inert particles that is a mixture of inert particles and combustion catalyst. The inert particles and the combustion catalyst preferably have a volumetric ratio of inert particles to catalyst between about 2:1 and about 4:1. The combustor has at least one heat exchanger within the combustion catalyst bed for heating a reformer reactant and generating steam. Preferably, the combustor includes at least two heat exchangers within the combustion catalyst bed, the heat exchanging elements have different surface areas.

Abstract: A compressor bleed air manifold includes annular outer flanges on opposite sides of the generally annular manifold plenum. The outer and inner flange geometries may be circumferentially tailored to produce optimal case stiffness and thermal response for blade-to-case clearances. The inner flanges are secured to one another by an inner bolt circle radially adjacent the flow path thereby improving the case stiffness, out of roundness and eliminating unsupported sections of the flowpath along an outer diameter thereof. The flanges of the outer bolt circle seal the plenum. The compressor bleed air manifold and the compressor casing load path are thereby isolated from one another.

Abstract: A liposome composition comprised of liposomes having the peptide boronic acid proteasome inhibitor compound bortezomib entrapped in the liposomes is described. The boronic acid compound is entrapped in the liposomes in the form of a boronate ester, subsequent to interaction with a liposome-entrapped polyol. In one embodiment, the liposomes have an outer coating of hydrophilic polymer chains and are used to treat a solid tumor in a subject.

Abstract: A liposome composition comprised of liposomes having a peptide boronic acid proteasome inhibitor compound entrapped in the liposomes is described. The boronic acid compound is entrapped in the liposomes in the form of a boronate ester, subsequent to interaction with a liposome-entrapped polyol. In one embodiment, the liposomes have an outer coating of hydrophilic polymer chains and are used to treat a malignancy in a subject.

Abstract: It has been found that inhibitors of the renin-angiotensin system are useful for the treatment or prevention of conditions associated with hypoxia or impaired metabolic function or efficiency. In particular, they may be used in connection with therapy of stroke or its recurrence, the acute treatment of myocardial infarction, and the treatment or prevention of wasting or cachexia, and are thus useful in treatment of the symptoms and signs of aging. These inhibitors may also be used to enhance function in healthy subjects.

Abstract: The present invention is related to an apparatus and method for irradiating a product package, comprising a radiation source directing a radiation beam along a beam direction towards said product package, conveying means for transporting said product package past said radiation source along a transport path, and reflecting means located on at least one side of the plane formed by said beam direction and said transport path. By adjusting the distance and angle of the reflecting means to the conveyor and beam, and improved dose uniformity ratio is obtained.

Abstract: A method of tuning a compressor stator blade having a base portion and an airfoil portion to achieve a desired natural frequency, includes a) identifying the natural frequency of the compressor stator blade; b) determining a different target natural frequency for the compressor stator blade; and c) removing material from the base portion of the compressor stator blade in an amount and in a configuration that achieves the target natural frequency. A frequency-tuned compressor stator blade includes an airfoil portion and a base portion, the base portion having a substantially solid rectangular shape; and a groove cut across a width dimension of the base portion, the groove having dimensions selected to obtain a predetermined natural frequency for the airfoil portion.

Abstract: An inhibitor of the renin-angiotensin system is useful for the treatment or prevention of the lipodystrophy syndrome, e.g. in AIDS patients also receiving anti-retroviral therapy.

Abstract: The invention provides methods for screening multimeric antibodies produced by mammalian cells to find those that exhibit a biological function. The methods can be used to screen large numbers of antibodies, which may be cell surface, secreted, or intracellular antibodies. Antibodies can be screened to find those that bind antigen more avidly or those that compete with a ligand that binds to the antigen for binding. Any biological function that can be tested in vitro can be used to screen the antibodies. Nucleic acids encoding the antibodies that exhibit the biological function can be obtained in a number of ways.

Abstract: Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also disclosed.

Abstract: It has been found that inhibitors of the rennin-angiotensin system are useful for the treatment or prevention of conditions associated with hypoxia or impaired metabolic function or efficiency. In particular, they may be used in connection with therapy of stroke or its recurrence, the acute treatment of myocardial infarction, and the treatment or prevention of wasting or cachexia, and are thus useful in treatment of the symptoms and signs of aging. These inhibitors may also be used to enhance function in healthy subjects.

Abstract: Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.

Abstract: Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.

Abstract: A method of preparing a coated optical fiber for coupling to a face of an optical device includes placing the coated fiber so that it extends through a stripping station, a cleaning station and a cleaving station. A stripper at the stripping station is brought into engagement with the fiber and relative motion between the fiber and the stripping station, the cleaning station and the cleaving station is effected lengthwise of the fiber, whereby the coating is stripped from a medial length segment of the fiber as the cleaning device at the cleaning station is activated for cleaning fragments of coating material from the medial length segment of the fiber as the medial length segment passes through the cleaning station and the cleaning device is deactivated and stripping is discontinued.

Abstract: A blade of an axial compressor comprising: an airfoil is disclosed that has a leading edge and a root; a platform attached to the root of the airfoil; a dovetail attached to a side of the platform opposite to the airfoil; a neck of the dovetail adjacent the platform, and a slot in the neck and generally parallel to the platform, and the slot extends from a front of the neck to position in the neck beyond a line formed by the leading edge of the blade.