Patents by Inventor Francis Rafferty

Francis Rafferty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MULTIPARAMETER MATERIALS, METHODS AND SYSTEMS FOR BIOREACTOR GLYCATED SPECIES MANUFACTURE
    Publication number: 20240166984
    Abstract: Methods for determining glycation on a molecule and/or a glycan structure on a glycosylated molecule through the use of a combination of spectroscopic analysis and chemometric modeling are described. In addition, methods and systems for producing a molecule with a desired level of glycation, including a non-glycated molecule, and/or a desired level of a glycan structure on a glycosylated molecule are described.
    Type: Application
    Filed: March 23, 2022
    Publication date: May 23, 2024
    Inventors: Caitlin O'MAHONY-BARTNETT, Barry J. MC CARTHY, Christopher W. RODE, Ronan HAYES, Fiona MADDEN, Jingjie MO, Francis C. MASLANKA, Kevin CLARK, Daniel A. TROUT, Pushpraj RANA, Emmanouela GRATSIA, Carl RAFFERTY, Karin M. BALSS, Olav LYNGBERG
  • MULTIPARAMETER MATERIALS, METHODS AND SYSTEMS FOR ENHANCED BIOREACTOR MANUFACTURE
    Publication number: 20240168033
    Abstract: Methods for determining glycation on a molecule and/or a glycan structure on a glycosylated molecule through the use of a combination of spectroscopic analysis and chemometric modeling are described. In addition, methods and systems for producing a molecule with a desired level of glycation, including a non-glycated molecule, and/or a desired level of a glycan structure on a glycosylated molecule are described.
    Type: Application
    Filed: March 22, 2022
    Publication date: May 23, 2024
    Inventors: Caitlin O'MAHONY-HARTNETT, Barry J. MC CARTHY, Christopher W. RODE, Ronan HAYES, Fiona MADDEN, Jingjie MO, Francis C. MASLANKA, Kevin CLARK, Daniel A. TROUT, Pushpraj RANA, Emmanouela GRATSIA, Carl RAFFERTY, Karin M. BALSS, Olav LYNGBERG
  • Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers
    Patent number: 6989448
    Abstract: The present invention provides compounds that block calcium channels having the Formula I shown below. The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, asthma, amyotropic lateral sclerosis, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.
    Type: Grant
    Filed: September 25, 2002
    Date of Patent: January 24, 2006
    Inventors: Lain-Yen Hu, Michael Francis Rafferty, Todd Robert Ryder, Anthony Denver Sercel, Yuntao Song
  • Method for printing an interrupt printing job
    Publication number: 20050128504
    Abstract: A method for printing an interrupt print job including the steps of receiving a primary print job and processing the primary print job with a primary processor to provide a plurality of primary pages to a print queue. The method further includes the steps receiving an interrupt print job and processing the interrupt print job with an interrupt processor to provide at least one interrupt page. The method further includes the step of printing the at least one interrupt page prior to printing at least one primary page in the page queue.
    Type: Application
    Filed: December 16, 2003
    Publication date: June 16, 2005
    Inventors: Patrick Bischel, Robert Borchers, Cuong Hoang, Michael Klein, Francis Rafferty, Martin Rivers, Dave Snow, Aaron Yoder
  • Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers
    Publication number: 20030060419
    Abstract: The present invention provides compounds that block calcium channels having the Formula I shown below.
    Type: Application
    Filed: September 25, 2002
    Publication date: March 27, 2003
    Inventors: Lain-Yen Hu, Michael Francis Rafferty, Todd Robert Ryder, Anthony Denver Sercel, Yuntao Song
  • Calcium channel blockers
    Publication number: 20030060632
    Abstract: The present invention provides compounds that block calcium channels having the Formula I shown below.
    Type: Application
    Filed: September 23, 2002
    Publication date: March 27, 2003
    Inventors: Lain-Yen Hu, Michael Francis Rafferty, Todd Robert Ryder
  • Calcium channel blockers
    Patent number: 6495715
    Abstract: The present invention provides compounds that block calcium channels having the Formula I shown below. The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: December 17, 2002
    Assignee: Warner-Lambert Company
    Inventors: Lain-Yen Hu, Michael Francis Rafferty, Todd Robert Ryder
  • Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers
    Patent number: 6469038
    Abstract: The present invention provides compounds that block calcium channels having the Formula I shown below. The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, asthma, amyotropic lateral sclerosis, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.
    Type: Grant
    Filed: September 18, 2000
    Date of Patent: October 22, 2002
    Assignee: Warner-Lambert Company
    Inventors: Lain-Yen Hu, Michael Francis Rafferty, Todd Robert Ryder, Anthony Denver Sercel, Yuntao Song
  • Substituted diarylalkyl amides as calcium channel antagonists
    Patent number: 6458781
    Abstract: The present invention provides compounds that block calcium channels and have the Formula I: The present invention also provides pharmaceutical compositions containing the compounds of Formula I and methods of using them to treat stroke, cerebral ischemia, head trauma, and epilepsy.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: October 1, 2002
    Inventors: David Thomas Connor, Lain-Yen Hu, Thomas Charles Malone, Michael Francis Rafferty, Bruce David Roth, Todd Robert Ryder, Anthony Denver Sercel, Yuntao Song
  • Conformationally semi-constrained quinoxaline 2,3-diones as neuroprotective agents
    Patent number: 6455698
    Abstract: A process is disclosed for the preparation of a compound of formula A process is also disclosed for preparing a compound of formula
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: September 24, 2002
    Assignee: Warner-Lambert Company
    Inventors: Brian Edward Kornberg, Sham Shridhar Nikam, Michael Francis Rafferty
  • Method for preventing and treating alcoholism
    Patent number: 6426368
    Abstract: GABA analogs are useful to prevent and treat gastrointestinal damage and ethanol withdrawal syndrome. Preferred treatments employ gabapentin or pregabalin.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: July 30, 2002
    Assignees: Warner-Lambert Company, University of Oklahoma
    Inventors: Lionel Bueno, Maria Chovet, Laurent Diop, Antonio Guglietta, Hilary J. Little, Michael Francis Rafferty, Jiayuan Ren, Charles Price Taylor, Jr., William Patrick Watson
  • Peptidyl calcium channel blockers
    Patent number: 6423689
    Abstract: The present invention provides compounds that block calcium channels having the Formula I shown below. The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: July 23, 2002
    Assignees: Warner-Lambert Company, Neurex Corporation
    Inventors: Richard John Booth, Louis Brogley, Wayne Livingston Cody, David Thomas Connor, Harriet Wall Hamilton, John Xiaoqiang He, Lain-Yen Hu, Leonard Joseph Lescosky, Thomas Charles Malone, Laszlo Nadasdi, Michael Francis Rafferty, Bruce David Roth, Diego F. Silva, Yuntao Song, Balazs G. Szoke, Laszlo Urge
  • Conformationally semi-constrained quinoxaline 2,3-diones as neuroprotective agents
    Publication number: 20020065415
    Abstract: Described are neuroprotective agents of Formula I 1
    Type: Application
    Filed: October 4, 2001
    Publication date: May 30, 2002
    Inventors: Brian Edward Kornberg, Sham Shridhar Nikam, Michael Francis Rafferty
  • Reduced dipeptide analogues as calcium channel antagonitsts
    Patent number: 6362174
    Abstract: The present invention provides novel N-type calcium channel blockers, compositions comprising them, and methods of their use. The compounds of the invention are useful in the treatment of stroke, cerebral ischemia, pain, epilepsy, and head trauma.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: March 26, 2002
    Assignee: Warner-Lambert Company
    Inventors: Michael Francis Rafferty, Yuntao Song
  • Reduced dipeptide analogues as calcium channel antagonitsts
    Publication number: 20020028801
    Abstract: The present invention provides novel N-type calcium channel blockers, compositions comprising them, and methods of their use. The compounds of the invention are useful in the treatment of stroke, cerebral ischemia, pain, epilepsy, and head trauma.
    Type: Application
    Filed: August 9, 2001
    Publication date: March 7, 2002
    Inventors: Michael Francis Rafferty, Yuntao Song
  • Conformationally semi-constrained quinoxaline 2,3-diones as neuroprotective agents
    Patent number: 6340758
    Abstract: Described are neuroprotective agents of Formula I wherein R is an amino acid or nitrogen heterocyclic ring which is saturated or unsaturated of from 5 to 8 members which may have additional oxygen or sulfur atoms therein. The other provisions or substituents are described in the specification.
    Type: Grant
    Filed: November 25, 1998
    Date of Patent: January 22, 2002
    Assignee: Warner-Lambert Company
    Inventors: Brian Edward Kornberg, Sham Shridhar Nikam, Michael Francis Rafferty
  • Tyrosine-derived compounds as calcium channel antagonists
    Patent number: 6323243
    Abstract: The present invention provides compounds that block calcium channels and have the Formula I: and pharmaceutically acceptable salts, esters, and pro-drugs thereof, wherein R1 and R2 are independently H, phenylcyclopentylcarbonyl, C1-C7 alkyl, cyclohexylmethyl, benzyl, C1-C5 alkylbenzyl, or C1-C5 alkoxybenzyl, A is —C(O)— or —CH2—; R3 is H or —CH3; R4 is C1-C4 alkyl or piperidin-1-ylethyl; R5 is phenyl-(CH2)n—, C1-C4 alkylphenyl-(CH2)n—, or halophenyl-(CH2)n—; and n is 1 or 2. The present invention also provides pharmaceutical compositions containing the compounds of Formula I and methods of using them to treat stroke, cerebral ischemia, head trauma, and epilepsy.
    Type: Grant
    Filed: October 24, 2000
    Date of Patent: November 27, 2001
    Assignee: Warner-Lambert Company
    Inventors: Michael Francis Rafferty, Yuntao Song
  • Reduced dipeptide analogues as calcium channel antagonists
    Patent number: 6316440
    Abstract: The present invention provides novel N-type calcium channel blockers, compositions comprising them, and methods of their use. The compounds of the invention are useful in the treatment of stroke, cerebral ischemia, pain, epilepsy, and head trauma.
    Type: Grant
    Filed: December 27, 1999
    Date of Patent: November 13, 2001
    Assignee: Warner-Lambert Company
    Inventors: Michael Francis Rafferty, Yuntao Song
  • Calcium channel blockers
    Publication number: 20010023249
    Abstract: The present invention provides compounds that block calcium channels having the Formula I shown below.
    Type: Application
    Filed: January 25, 2001
    Publication date: September 20, 2001
    Inventors: Lain-Yen Hu, Michael Francis Rafferty, Todd Robert Ryder
  • Method for preventing and treating alcoholism
    Publication number: 20010014698
    Abstract: GABA analogs are useful to prevent and treat gastrointestinal damage and ethanol withdrawal syndrome. Preferred treatments employ gabapentin or pregabalin.
    Type: Application
    Filed: March 13, 2001
    Publication date: August 16, 2001
    Inventors: Lionel Bueno, Maria Chovet, Laurent Diop, Antonio Guglietta, Hilary J. Little, Michael Francis Rafferty, Jiayuan Ren, Charles Price Taylor,, W. P. Watson