Patents by Inventor Francis Vincent Lamberti
Francis Vincent Lamberti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10383981Abstract: The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking.Type: GrantFiled: March 9, 2017Date of Patent: August 20, 2019Assignee: Pioneer Surgical Technology, Inc.Inventors: Francis Vincent Lamberti, Richard Chris Klann, Ronald Stewart Hill
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Patent number: 10342892Abstract: The present invention is direct to a body-absorbable, mechanically hemostatic composition comprising a solid poloxamer having an average molecular weight of about 7,000 g/mol to about 15,000 g/mol, a high molecular weight dextran, optionally a fatty acid salt, and water, and a method for mechanically controlling the bleeding of bone comprising applying an effective amount of the composition to the affected area.Type: GrantFiled: January 18, 2018Date of Patent: July 9, 2019Assignee: Pioneer Surgical Technology, Inc.Inventors: Francis Vincent Lamberti, Barbara Sage
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Patent number: 10265436Abstract: The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate.Type: GrantFiled: March 10, 2017Date of Patent: April 23, 2019Assignee: Pioneer Surgical Technology, Inc.Inventors: Francis Vincent Lamberti, Richard Chris Klann, Ronald Stewart Hill
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Publication number: 20180236125Abstract: The present invention is direct to a body-absorbable, mechanically hemostatic composition comprising a solid poloxamer having an average molecular weight of about 7,000 g/mol to about 15,000 g/mol, a high molecular weight dextran, optionally a fatty acid salt, and water, and a method for mechanically controlling the bleeding of bone comprising applying an effective amount of the composition to the affected area.Type: ApplicationFiled: January 18, 2018Publication date: August 23, 2018Inventors: Francis Vincent Lamberti, Barbara Sage
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Patent number: 9895465Abstract: The present invention is direct to a body-absorbable, mechanically hemostatic composition comprising a solid poloxamer having an average molecular weight of about 7,000 g/mol to about 15,000 g/mol, a high molecular weight dextran, optionally a fatty acid salt, and water, and a method for mechanically controlling the bleeding of bone comprising applying an effective amount of the composition to the affected area.Type: GrantFiled: March 12, 2015Date of Patent: February 20, 2018Assignee: Pioneer Surgical Technology, Inc.Inventors: Francis Vincent Lamberti, Barbara Sage
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Publication number: 20170197013Abstract: The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking.Type: ApplicationFiled: March 9, 2017Publication date: July 13, 2017Inventors: Francis Vincent Lamberti, Richard Chris Klann, Ronald Stewart Hill
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Publication number: 20170182215Abstract: The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate.Type: ApplicationFiled: March 10, 2017Publication date: June 29, 2017Inventors: Francis Vincent Lamberti, Richard Chris Klann, Ronald Stewart Hill
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Patent number: 9623146Abstract: The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking.Type: GrantFiled: January 30, 2015Date of Patent: April 18, 2017Assignee: RTI Surgical Technology, Inc.Inventors: Francis Vincent Lamberti, Richard Chris Klann, Ronald Stewart Hill
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Patent number: 9610382Abstract: The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate.Type: GrantFiled: November 7, 2013Date of Patent: April 4, 2017Assignee: RTI Surgical, Inc.Inventors: Francis Vincent Lamberti, Richard Chris Klann, Ronald Stewart Hill
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Patent number: 9370608Abstract: The present disclosure provides compositions useful in regeneration of connective tissue, particularly bone. The compositions comprise a continuous matrix formed of a polypeptide crosslinked with a second polymer and further comprise particles of a porous, osteoconductive material dispersed in the continuous matrix. The composition can be provided in a dehydrated form. The disclosure further provides methods of preparing the composition in a clinically useful form, methods of using the composition in regenerating bone, and kits including the composition.Type: GrantFiled: December 12, 2014Date of Patent: June 21, 2016Assignee: RTI Surgical Inc.Inventors: Francis Vincent Lamberti, Ronald Stewart Hill, Adam MacMillan, Edward Ahn, Brian Schlossberg, Stephen Capistron, William H. Lloyd
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Publication number: 20150258239Abstract: The present invention is direct to a body-absorbable, mechanically hemostatic composition comprising a solid poloxamer having an average molecular weight of about 7,000 g/mol to about 15,000 g/mol, a high molecular weight dextran, optionally a fatty acid salt, and water, and a method for mechanically controlling the bleeding of bone comprising applying an effective amount of the composition to the affected area.Type: ApplicationFiled: March 12, 2015Publication date: September 17, 2015Inventors: Francis Vincent Lamberti, Barbara Sage
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Publication number: 20150140116Abstract: The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking.Type: ApplicationFiled: January 30, 2015Publication date: May 21, 2015Inventors: Francis Vincent Lamberti, Richard Chris Klann, Ronald Stewart Hill
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Publication number: 20150098998Abstract: The present disclosure provides compositions useful in regeneration of connective tissue, particularly bone. The compositions comprise a continuous matrix formed of a polypeptide crosslinked with a second polymer and further comprise particles of a porous, osteoconductive material dispersed in the continuous matrix. The composition can be provided in a dehydrated form. The disclosure further provides methods of preparing the composition in a clinically useful form, methods of using the composition in regenerating bone, and kits including the composition.Type: ApplicationFiled: December 12, 2014Publication date: April 9, 2015Inventors: Francis Vincent Lamberti, Ronald Stewart Hill, Adam MacMillan, Edward Ahn, Brian Schlossberg, Stephen Capistron, William H. Lloyd
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Patent number: 8957050Abstract: The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking.Type: GrantFiled: March 11, 2013Date of Patent: February 17, 2015Assignee: Pioneer Surgical Technology, Inc.Inventors: Francis Vincent Lamberti, Richard Chris Klann, Ronald Stewart Hill
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Patent number: 8940317Abstract: The present disclosure provides compositions useful in regeneration of connective tissue, particularly bone. The compositions comprise a continuous matrix formed of a polypeptide crosslinked with a second polymer and further comprise particles of a porous, osteoconductive material dispersed in the continuous matrix. The composition can be provided in a dehydrated form. The disclosure further provides methods of preparing the composition in a clinically useful form, methods of using the composition in regenerating bone, and kits including the composition.Type: GrantFiled: December 20, 2012Date of Patent: January 27, 2015Assignee: Pioneer Surgical TechnologyInventors: Francis Vincent Lamberti, Ronald Stewart Hill, Adam MacMillan, Edward Ahn, Brian Schlossberg, Stephen Capistron, William H. Lloyd
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Publication number: 20140066694Abstract: The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate.Type: ApplicationFiled: November 7, 2013Publication date: March 6, 2014Applicant: Pioneer Surgical Technology, Inc.Inventors: Francis Vincent Lamberti, Richard Chris Klann, Ronald Stewart Hill