Abstract: The present invention provides markers of endothelial progenitor cells (EPCs) and use of those markers and reagents that bind thereto to detect EPC cells or diagnose, prognose, treat or prevent EPC-associated conditions.

Abstract: The present disclosure provides antibodies and antigen binding fragments thereof that bind to an epitope within an interleukin-3 receptor ?.

Abstract: A heat exchanger (1) for gas, in particular the exhaust gases of an engine, comprising a bundle of tubes arranged inside a shell (2) and intended for the circulation of gas with an exchange of heat with at least one stream of refrigerant fluid, said tubes being fixed by their ends between two support plates (5) coupled at each end of the shell (2), and deflection means arranged inside the shell (2) able to direct the at least one stream of refrigerant fluid inside the shell (2). The deflection means comprises a longitudinal deflector (6, 6a) substantially parallel to the tube bundle and intended to divide the shell (2) into two circuits, said deflector (6, 6a) being fixed by its longitudinal edges to the internal walls of the shell (2) and by its transverse edges to the two support plates (5) by welding. This ensures more effective mounting of said deflector inside the exchanger.

Abstract: The invention provides a method for the treatment of Ph+ leukemia in a patient comprising administering to the patient (i) a BCR-ABL tyrosine kinase inhibitor, and (ii) an agent which selectively binds to a cell surface receptor expressed on Ph+ leukemic stem cells. The invention further provides for the use of (i) and (ii) in, or in the manufacture of a medicament for, the treatment of Ph+ leukemia in a patient; and a composition for the treatment of Ph+ leukemia in a patient comprising (i) and (ii); and kits comprising (i) and (ii). In some embodiments, the tyrosine kinase inhibitor is or is not imatinib; or is selected from the group consisting of dasatinib, nilotinib, bosutinib, axitinib, cediranib, crizotinib, damnacanthal, gefitinib, lapatinib, lestaurtinib, neratinib, semaxanib, sunitinib, toceranib, tyrphostins, vandetanib, vatalanib, INNO-406, AP24534, XL228, PHA-739358, MK-0457, SGX393 and DC2036; or is selected from the group consisting of dasatinib and nilotinib.

Abstract: A heat exchanger (1) for gases, in particular for the exhaust gases of an engine, comprising a bundle of tubes (2) arranged inside a casing (3), intended for the circulation of the gases in order to exchange heat with a coolant, at least one gas tank (6) that can be fitted to one end of the casing (3) and connected to the gas recirculation line, and a particle filter (7) for filtering the exhaust gases, associated with said gas tank (6). Said filter (7) is incorporated into the gas tank (6) and forms a single inseparable part that can be fitted to the casing (3) of the exchanger (1). Preferably, the filter (7) is incorporated into the gas tank (6) by welding. A filter which is fully incorporated into the gas tank in a single part is obtained, which therefore facilitates the assembly thereof to the exchanger casing.

Abstract: An instrument cluster assembly having a biasable member for reducing noise produced by vibration, where the instrument cluster assembly includes a light housing, a perimeter sidewall formed as part of the light housing, and at least one biasable member integrally formed with the perimeter sidewall. A mask is selectively connected to the light housing, and an inner perimeter sidewall is formed as part of the mask. The biasable member includes a base portion formed with the perimeter sidewall, and a flange portion integrally formed with the base portion. At least a portion of the flange portion is in contact with the inner perimeter sidewall of the mask, such that the flange portion deflects to absorb vibration between the light housing and the mask.

Abstract: The present invention provides a method of screening a mammal for the onset or predisposition to the onset of a neuropsychiatric disorder. More particularly, the present invention provides a method of screening a mammal for the onset or predisposition to the onset of schizophrenia by screening for a decrease in the functional level of protein 14-3-3?. In a related aspect, the present invention also provides a means of monitoring a patient diagnosed with a neuropsychiatric disorder, such as schizophrenia, by screening for changes to functional levels of protein 14-3-3?. This may be useful, for example, in the context of evaluating the effectiveness of a prophylactic or therapeutic treatment regime or otherwise monitoring the impact of physiological or metabolic changes which may occur in a patient.

Abstract: Existing video surveillance security approaches enhanced with suitable functionality of the telecommunications wireless network are provided. Security personnel are equipped with hand-held devices capable of recording video, photos, audio, and text. This data is geo-tagged and time-stamped by the application and uploaded to the telecommunications network and stored in the network. As such, the geo-tagged, time-stamped information is immediately available to other investigators who are in the same geographic vicinity through access controls administered by a secure social network. The information may also be accessible from remote locations via the internet. All wireless and Internet communications may be protected using end-to-end secure transport layer communications protocols.

Abstract: The fold-out shelving unit comprises a rear panel (1), side panels (2) movable between a folded position, wherein said panels are coplanar, and an expanded position, wherein the side panels (2) are perpendicular to the rear panel (1), a moving support panel (3) extending from one to the other of the side panels (2) and a shelf panel (4) foldable over the rear panel (1). The support panel (3) and the shelf panel (4) are cinematically linked to one another and to the side panels (2) by first and second cinematic linking means so that the support panel (3) gets closer and away parallel to the rear panel (1) and the shelf panel (4) pivots relative to the rear panel (1) when the side panels (2) move between the folded position and the expanded position.

Abstract: The presently disclosed embodiments relate generally to an image forming apparatus comprising an overcoat layer disposed directly over in contact with the top circumferential surface of a seamed intermediate transfer belt, and methods for making the same. The overcoat layer, comprising a film forming A-B diblock copolymer and conductive particles dispersion, not only renders the seam area physical/mechanical/electrical continuity for achieving absolute belt surface imageability to function like a seamless intermediate transfer belt, it also provides increased mechanical strength to resist fatigue-bend cracking under normal dynamic intermediate transfer belt machine cycling conditions in the field. The overcoat of this disclosure thus helps to reduce wear and extend service life of the belt.

Abstract: The present invention relates to a method for the detection of potentially pathogenic agents and/or capable of causing deterioration in a plant sample, representative of one or several batches of plant product, characterized in that it comprises the concentration of a plant sample by centrifugation and the analysis of the presence or amount of potentially pathogenic agents and/or capable of causing deterioration in the concentrated sample obtained. Likewise, the present invention relates to a system for detection and analysis of potentially pathogenic agents and/or capable of causing deterioration in a plant sample to carry out said method.

Abstract: The present invention relates generally to the field of crystallography. More particularly, the present invention provides crystalline forms of a complex between granulocyte macrophage-colony stimulating factor (GM-CSF) and its receptor (GM-CSFR). The present invention further provides methods for the design and selection of modulators of GM-CSF/GM-CSFR interaction and signaling as well as signaling of other cytokines.

Abstract: This invention relates to systems and methods for catalytic steam cracking of non-asphaltene containing heavy hydrocarbon fractions. The method enables upgrading heavy hydrocarbons to hydrocarbons capable of being transported through pipelines and/or a pretreated step before further treatment in an upgrading refinery, including the steps of separating the heavy hydrocarbon mixture into a light fraction, a full gasoil fraction and a vacuum residue fraction with or without at least partial reduction or asphaltenes; adding a catalyst to the full gasoil and/or to the blend of this with a reduced asphaltenes fraction and subjecting the catalyst-full gasoil and/or deasphalted oil fraction to catalytic steam cracking to form an effluent stream; separating the effluent stream into a gas stream and a liquid stream; and mixing the liquid stream with the light fraction and the vacuum residue fraction to form an upgraded oil. The system includes hardware capable of performing the method.

Abstract: An apparatus and method for completing a payment transaction using a network-connectable device is disclosed. When a payer initiates a payment transaction to a vendor using the network connectable device, a unique identifier and current geolocation of the network-connectable device are sent to a payment server together with a server payment transaction message containing information about the payment transaction. The payment server compares the geolocation with the vendor location and one or more predetermined locations associated with the payer, for example, a home or workplace. Upon a successful comparison, the payment retrieves a third party payment record from a mapping database and uses it to complete the payment transaction with a third party payment processing system.

Abstract: The present invention comprises a percutaneously implantable replacement heart valve device and a method of making same. The replacement heart valve device comprises a stent member made of stainless steel or self-expanding nitinol, a biological tissue artificial valve means disposed within the inner space of the stent member. An implantation and delivery system having a central part which consists of a flexible hollow tube catheter that allows a metallic wire guide to be advanced inside it. The endovascular stented-valve is a glutaraldehyde fixed bovine pericardium which has two or three cusps that open distally to permit unidirectional blood flow.

Abstract: The present invention relates generally to ultradispersed catalyst compositions and methods for preparing such catalysts. In particular, the invention provides catalyst composition of the general formula: BxMyS[(1.1 to 4.6)y+(0.5 to 4)x] where B is a group VIIIB non-noble metal and M is a group VI B metal and 0.05?y/x?15.

Abstract: The present invention relates generally to ultradispersed catalyst compositions and methods for preparing such catalysts. In particular, the invention provides catalyst composition of the general formula: BxMyS[(1.1 to 4.6)y+(0.5 to 4)x] where B is a group VIIIB non-noble metal and M is a group VI B metal and 0.05?y/x?15.

Abstract: A self-expanding foldable structure for a display has a structure that includes a pair of side walls (2) hinged at respective connection edges (2a) to opposing edges of a back wall (1) and a shelf (3) linked to the back and side walls (1, 2) such that they can adopt a flat position in which the back wall, side walls and shelf (1, 2, 3) are substantially coplanar and an expanded position in which the back wall, side walls and shelf (1, 2, 3) form respective dihedrons. An elastic element is arranged to push the structure to the expanded position. The side walls (2) comprise a transverse fold line (14) having one or more scored sections (14a) wherein an inner structure of the wall material is crushed, in combination with one or more cut sections (14b) wherein said inner structure of the wall material has flat edges that can mutually face and support one another in the expanded position.

Abstract: The present invention relates generally to ultradispersed catalyst compositions and methods for preparing such catalysts. In particular, the invention provides catalyst composition of the general formula: BxMyS[(1.1 to 4.6)y+(0.5 to 4)x] where B is a group VIIIB non-noble metal and M is a group VI B metal and 0.05?y/x?15.

Abstract: The invention provides a method for the treatment of Ph+ leukemia in a patient comprising administering to the patient (i) a BCR-ABL tyrosine kinase inhibitor, and (ii) an agent which selectively binds to a cell surface receptor expressed on Ph+ leukemic stem cells. The invention further provides for the use of (i) and (ii) in, or in the manufacture of a medicament for, the treatment of Ph+ leukemia in a patient; and a composition for the treatment of Ph+ leukemia in a patient comprising (i) and (ii); and kits comprising (i) and (ii). In some embodiments, the tyrosine kinase inhibitor is or is not imatinib; or is selected from the group consisting of dasatinib, nilotinib, bosutinib, axitinib, cediranib, crizotinib, damnacanthal, gefitinib, lapatinib, lestaurtinib, neratinib, semaxanib, sunitinib, toceranib, tyrphostins, vandetanib, vatalanib, INNO-406, AP24534, XL228, PHA-739358, MK-0457, SGX393 and DC2036; or is selected from the group consisting of dasatinib and nilotinib.