Abstract: Compounds of Formula (I) and Formula (II), which are capable of binding to granzyme B. Also provided herein are pharmaceutical compositions comprising such for use in, for example, imaging Granzyme B and/or treating immunoregulatory abnormalities.

Abstract: A method, apparatus, and computer-readable medium for efficiently optimizing a phenotype with a specialized prediction model, including receiving constraints, encoding genotype information in experimental data points corresponding to the constraints experiential genotype vectors, the experimental data points comprising the genotype information and phenotype information corresponding to the genotype information, training a phenotype prediction model based on the experiential genotype vectors, the corresponding phenotype information, and the one or more constraints, applying the phenotype prediction model to available genotypes corresponding to the constrains to generate scores, determining result genotypes based on a ranking of the available genotypes according to the scores, and generating, a result based on the result genotypes, the result indicating one or more genetic constructs for testing.

Abstract: A method, apparatus, and computer-readable medium for efficiently optimizing a phenotype with a combination of a generative and a predictive model, training a phenotype prediction model based on experiential genotype vectors, training a genotype generation model based on sample genotype vectors, generating new genotype vectors, applying the phenotype prediction model to the new genotype vectors to generate scores, determining result genotypes based on a ranking of the available genotypes according to the scores, and generating a result based on the result genotypes, the result indicating one or more genetic constructs for testing.

Abstract: A method, apparatus, and computer-readable medium for efficiently optimizing a phenotype with a specialized prediction model, including receiving constraints, encoding genotype information in experimental data points corresponding to the constraints experiential genotype vectors, the experimental data points comprising the genotype information and phenotype information corresponding to the genotype information, training a phenotype prediction model based on the experiential genotype vectors, the corresponding phenotype information, and the one or more constraints, applying the phenotype prediction model to available genotypes corresponding to the constrains to generate scores, determining result genotypes based on a ranking of the available genotypes according to the scores, and generating, a result based on the result genotypes, the result indicating one or more genetic constructs for testing.

Abstract: A method, apparatus, and computer-readable medium for efficiently optimizing a phenotype with a combination of a generative and a predictive model, training a phenotype prediction model based on experiential genotype vectors, training a genotype generation model based on sample genotype vectors, generating new genotype vectors, applying the phenotype prediction model to the new genotype vectors to generate scores, determining result genotypes based on a ranking of the available genotypes according to the scores, and generating a result based on the result genotypes, the result indicating one or more genetic constructs for testing.

Abstract: A method, apparatus, and computer-readable medium for optimal pooling of nucleic acid samples for next generation sequencing, including receiving sample records corresponding to samples, each sample record comprising a sample identifier and a nucleic acid reference sequence of the sample, determining unique nucleic acid reference sequences in the sample records, computing, a nucleic acid overlaps between the unique nucleic acid reference sequences, and determining an optimal grouping of the plurality of samples into a plurality of sample pools based at least in part on the nucleic acid reference sequence of each sample record, the nucleic acid overlaps between the unique nucleic acid reference sequences, and one or more constraints, the one or more constraints including a maximum overlap constraint.

Abstract: A method, apparatus, and computer-readable medium for efficiently optimizing a phenotype with a combination of a generative and a predictive model, training a phenotype prediction model based on experiential genotype vectors, training a genotype generation model based on sample genotype vectors, generating new genotype vectors, applying the phenotype prediction model to the new genotype vectors to generate scores, determining result genotypes based on a ranking of the available genotypes according to the scores, and generating a result based on the result genotypes, the result indicating one or more genetic constructs for testing.

Abstract: A method, apparatus, and computer-readable medium for efficiently optimizing a phenotype with a specialized prediction model, including receiving constraints, encoding genotype information in experimental data points corresponding to the constraints experiential genotype vectors, the experimental data points comprising the genotype information and phenotype information corresponding to the genotype information, training a phenotype prediction model based on the experiential genotype vectors, the corresponding phenotype information, and the one or more constraints, applying the phenotype prediction model to available genotypes corresponding to the constrains to generate scores, determining result genotypes based on a ranking of the available genotypes according to the scores, and generating, a result based on the result genotypes, the result indicating one or more genetic constructs for testing.

Abstract: An evaporative cooler assembly utilizes available water runoff and a filtration mechanism to increase efficiency and maintain an existing evaporative cooler. The assembly includes a main housing and a first intake vent coupled to and extending through the main housing. A first evaporative pad positioned in the main housing adjacent to the first intake vent. A blower is positioned in the main housing for urging the ambient air through the intake vent and out of an output duct. A reservoir is provided extrinsic to the main housing. A delivery line is in fluid communication between the reservoir and the evaporative pad. A pump is operationally coupled to the delivery line urging water through the delivery line. A return line is coupled to the main housing and the reservoir wherein, the return line returns unevaporated fluid to the reservoir.

Abstract: Example embodiments relate to a multiple inputs and multiple outputs (MIMO) analyzer for an accurate control of electromagnetic fields inside a multimode resonant chamber with two or more cavities coupled in an accurate way through a slotted piece with slots or waveguide. The MIMO analyzer may include broadband antennas, different types of lenses, and different stirrers, which may be both metallic and non-metallic. These elements, together with some processes such as precise location of under-test elements out of the lower cavity allow for controlling the electromagnetic fields on its interior. This control permits the emulation of the behavior of wireless communication terminals under different fading scenarios, both indoors and outdoors. Some of the features and procedures of the MIMO analyser may be used in industrial microwave heating processes for drying and curing of materials, also known as microwave ovens, allowing a greater efficiency and homogenization in the processes.

Abstract: The present invention allows for an accurate control of the electromagnetic fields inside a multimode resonant chamber with two or more cavities coupled in an accurate way through a metallic plate with slots or waveguide. The multiple inputs and multiple outputs analyzer (MIMO Analyzer) features several elements such as: broadband antennas, metallic slotted plate, different types of lenses and different stirrers, both metallic and non-metallic. These elements, together with some procedures such as precise location of under-test elements out of the lower cavity allow for controlling the electromagnetic fields on its interior. This control permits the emulation of the behaviour of wireless communication terminals under different fading scenarios, both indoors and outdoors.