Patents by Inventor Francisco Arias

Francisco Arias has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7774920
    Abstract: A method of forming microstructures. An article including a metal atom precursor is disproportionally exposed to electromagnetic radiation in an amount and intensity sufficient to convert some of the precursor to elemental metal. Additional conductive material may then be deposited onto the elemental metal to produce a microstructure.
    Type: Grant
    Filed: April 25, 2007
    Date of Patent: August 17, 2010
    Assignee: President and Fellows of Harvard College
    Inventors: Tao Deng, Francisco Arias, Rustem F. Ismagilov, Paul J. A. Kenis, George M. Whitesides
  • Patent number: 7763203
    Abstract: A method for manufacturing microneedle structures is disclosed using soft lithography and photolithography, in which micromold structures made of a photoresist material or PDMS are created. The micromold manufacturing occurs quite quickly, using inexpensive materials and processes. Once the molds are available, using moldable materials such as polymers, microneedle arrays can be molded or embossed in relatively fast procedures. In some cases a sacrificial layer is provided between the forming micromold and its substrate layer, for ease of separation. The microneedles themselves can be solid projections, hollow “microtubes,” or shallow “microcups.” Electrodes can be formed on the microneedle arrays, including individual electrodes per hollow microtube.
    Type: Grant
    Filed: December 3, 2003
    Date of Patent: July 27, 2010
    Assignee: Corium International, Inc.
    Inventors: Francisco Arias, Faiz Feisal Sherman, Grover David Owens
  • Patent number: 7399579
    Abstract: A method of forming microstructures. An article including a metal atom precursor is disproportionally exposed to electromagnetic radiation in an amount and intensity sufficient to convert some of the precursor to elemental metal. Additional conductive material may then be deposited onto the elemental metal to produce a microstructure.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: July 15, 2008
    Assignee: President & Fellows of Harvard College
    Inventors: Tao Deng, Francisco Arias, Rustem F. Ismagilov, Paul J. A. Kenis, George M. Whitesides
  • Publication number: 20070254110
    Abstract: A method of forming microstructures. An article including a metal atom precursor is disproportionally exposed to electromagnetic radiation in an amount and intensity sufficient to convert some of the precursor to elemental metal. Additional conductive material may then be deposited onto the elemental metal to produce a microstructure.
    Type: Application
    Filed: April 25, 2007
    Publication date: November 1, 2007
    Applicant: President and Fellows of Harvard College
    Inventors: Tao Deng, Francisco Arias, Rustem Ismagilov, Paul Kenis, George Whitesides
  • Publication number: 20040182713
    Abstract: A method of forming microstructures. An article including a metal atom precursor is disproportionally exposed to electromagnetic radiation in an amount and intensity sufficient to convert some of the precursor to elemental metal. Additional conductive material may then be deposited onto the elemental metal to produce a microstructure.
    Type: Application
    Filed: January 23, 2004
    Publication date: September 23, 2004
    Applicant: President and Fellows of Harvard College
    Inventors: Tao Deng, Francisco Arias, Rustem F. Ismagilov, Paul J.A. Kenis, George M. Whitesides
  • Publication number: 20040146611
    Abstract: A method for manufacturing microneedle structures is disclosed using soft lithography and photolithography, in which micromold structures made of a photoresist material or PDMS are created. The micromold manufacturing occurs quite quickly, using inexpensive materials and processes. Once the molds are available, using moldable materials such as polymers, microneedle arrays can be molded or embossed in relatively fast procedures. In some cases a sacrificial layer is provided between the forming micromold and its substrate layer, for ease of separation. The microneedles themselves can be solid projections, hollow “microtubes,” or shallow “microcups.” Electrodes can be formed on the microneedle arrays, including individual electrodes per hollow microtube.
    Type: Application
    Filed: December 3, 2003
    Publication date: July 29, 2004
    Applicant: The Procter & Gamble Company
    Inventors: Francisco Arias, Faiz Feisal Sherman, Grover David Owens
  • Patent number: 6706165
    Abstract: A method of forming microstructures. An article including a metal atom precursor is disproportionally exposed to electromagnetic radiation in an amount and intensity sufficient to convert some of the precursor to elemental metal. Additional conductive material may then be deposited onto the elemental metal to produce a microstructure.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: March 16, 2004
    Assignee: President and Fellows of Harvard College
    Inventors: Tao Deng, Francisco Arias, Rustem F. Ismagilov, Paul J. A. Kenis, George M. Whitesides
  • Patent number: 6663820
    Abstract: A method for manufacturing microneedle structures is disclosed using soft lithography and photolithography, in which micromold structures made of a photoresist material or PDMS are created. The micromold manufacturing occurs quite quickly, using inexpensive materials and processes. Once the molds are available, using moldable materials such as polymers, microneedle arrays can be molded or embossed in relatively fast procedures. In some cases a sacrificial layer is provided between the forming micromold and its substrate layer, for ease of separation. The microneedles themselves can be solid projections, hollow “microtubes,” or shallow “microcups.” Electrodes can be formed on the microneedle arrays, including individual electrodes per hollow microtube.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: December 16, 2003
    Assignee: The Procter & Gamble Company
    Inventors: Francisco Arias, Faiz Feisal Sherman, Grover David Owens
  • Patent number: 6652478
    Abstract: A hollow microneedle with a substantially sharp edge is provided that includes at least one longitudinal blade at the top surface or tip of the microneedle to aid in penetration of the stratum corneum of skin. In a preferred embodiment, there are two such longitudinal blades that are constructed on opposite surfaces at approximately a 180° angle along the cylindrical side wall of the microneedle. Each edged blade has a cross-section that, when viewed from above the microneedle top, has an isosceles triangle profile. The blade's edge can run the entire length of the microneedle from its very top surface to its bottom surface where it is mounted onto the substrate, or the edge can be discontinued partway down the length of the microneedle. A star-shaped solid microneedle also is provided having at least one blade with a relatively sharp edge to assist in penetrating the stratum corneum of skin.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: November 25, 2003
    Assignee: The Procter & Gamble Company
    Inventors: Vladimir Gartstein, Dragan Danilo Nebrigic, Grover David Owens, Faiz Feisal Sherman, Vadim Vladimirovich Yuzhakov, Francisco Arias
  • Patent number: 6591124
    Abstract: A strip-like microneedle device is provided that includes an array of hollow microneedles, a diaphragm pump to extract interstitial fluid from skin, and a sensor that detects the concentration of the fluid. The microneedle device can be interfaced to an external sensor to produce a reading, or can be self-contained. One version uses an attachable/detachable microneedle array as a single-use, disposable unit. The device is portable, and is used by placing one finger on the microneedle array, and actuating the diaphragm pump with another finger, thereby obtaining the fluid sample. Solid coated or transparent microneedles could instead be used as an in-situ sensor, with either electrodes or an optical sensor.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: July 8, 2003
    Assignee: The Procter & Gamble Company
    Inventors: Faiz Feisal Sherman, Francisco Arias, Vladimir Gartstein, Grover David Owens, Milan Marcel Jevtitch, Chow Chi Huang
  • Publication number: 20020169411
    Abstract: A strip-like microneedle device is provided that includes an array of hollow microneedles, a diaphragm pump to extract interstitial fluid from skin, and a sensor that detects the concentration of the fluid. The microneedle device can be interfaced to an external sensor to produce a reading, or can be self-contained. One version uses an attachable/detachable microneedle array as a single-use, disposable unit. The device is portable, and is used by placing one finger on the microneedle array, and actuating the diaphragm pump with another finger, thereby obtaining the fluid sample. Solid coated or transparent microneedles could instead be used as an in-situ sensor, with either electrodes or an optical sensor.
    Type: Application
    Filed: May 11, 2001
    Publication date: November 14, 2002
    Applicant: The Procter & Gamble Co.
    Inventors: Faiz Feisal Sherman, Francisco Arias, Vladimir Gartstein, Grover David Owens, Milan Marcel Jevtitch, Chow Chi Huang
  • Publication number: 20020133129
    Abstract: A method for manufacturing microneedle structures is disclosed using soft lithography and photolithography, in which micromold structures made of a photoresist material or PDMS are created. The micromold manufacturing occurs quite quickly, using inexpensive materials and processes. Once the molds are available, using moldable materials such as polymers, microneedle arrays can be molded or embossed in relatively fast procedures. In some cases a sacrificial layer is provided between the forming micromold and its substrate layer, for ease of separation. The microneedles themselves can be solid projections, hollow “microtubes,” or shallow “microcups.” Electrodes can be formed on the microneedle arrays, including individual electrodes per hollow microtube.
    Type: Application
    Filed: March 14, 2001
    Publication date: September 19, 2002
    Inventors: Francisco Arias, Faiz Feisal Sherman, Grover David Owens
  • Publication number: 20010045362
    Abstract: A method of forming microstructures. An article including a metal atom precursor is disproportionally exposed to electromagnetic radiation in an amount and intensity sufficient to convert some of the precursor to elemental metal. Additional conductive material may then be deposited onto the elemental metal to produce a microstructure.
    Type: Application
    Filed: January 5, 2001
    Publication date: November 29, 2001
    Inventors: Tao Deng, Francisco Arias, Rustem F. Ismagilov, Paul J.A. Kenis, George M. Whitesides