Patents by Inventor Francisco González-Bobes

Francisco González-Bobes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted quinolinylcyclohexylpropanamide compounds and improved methods for their preparation
    Patent number: 11919863
    Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.
    Type: Grant
    Filed: December 16, 2021
    Date of Patent: March 5, 2024
    Assignee: Bristol-Myers Squibb Company
    Inventors: Albert J. Delmonte, Benjamin M. Cohen, Kenneth Joseph Fraunhoffer, Sergei Kolotuchin, Francisco Gonzalez-Bobes, Gregory Louis Beutner, Adam Joseph Freitag, Michael Scott Bultman, Yu Fan, Prantik Maity, Ian Scott Young, Hilary Plake Beck, Maksim Osipov, Jay Patrick Powers, Maureen Kay Reilly, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky
  • SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION
    Publication number: 20220267273
    Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.
    Type: Application
    Filed: December 16, 2021
    Publication date: August 25, 2022
    Inventors: Albert J. DELMONTE, Benjamin M. COHEN, Kenneth Joseph FRAUNHOFFER, Sergei KOLOTUCHIN, Francisco GONZALEZ-BOBES, Gregory Louis BEUTNER, Adam Joseph FREITAG, Michael Scott BULTMAN, Yu FAN, Prantik MAITY, Ian Scott YOUNG, Hilary Plake BECK, Maksim OSIPOV, Jay Patrick POWERS, Maureen Kay REILLY, Hunter Paul SHUNATONA, James Ross WALKER, Mikhail ZIBINSKY
  • PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRAZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-OXOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE
    Publication number: 20220177482
    Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
    Type: Application
    Filed: February 22, 2022
    Publication date: June 9, 2022
    Inventors: Burcu Selin Aytar, Alina Borovika, Collin Chan, Joerg Deerberg, Nathan R. Domagalski, Martin D. Eastgate, Yu Fan, Michael David Bengt Fenster, Robert V. Forest, Francisco Gonzalez-Bobes, Rebecca A. Green, Matthew R. Hickey, Nathaniel David Kopp, Thomas E. La Cruz, Kathleen Lauser, Hong Geun Lee, David K. Leahy, Helen Y. Luo, Thomas M. Razler, Scott A. Savage, Chris Sfouggatakis, Maxime C.D. Soumeillant, Serge Zaretsky, Bin Zheng, Ye Zhu
  • Synthetic process
    Patent number: 11332442
    Abstract: The invention generally relates to a process for preparing compounds, including Compound of Formula (I), useful as key intermediates in the preparation of compounds having ROR?t antagonist properties.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: May 17, 2022
    Assignees: Bristol-Myers Squibb Company, Syngene International Limited
    Inventors: William P. Gallagher, John Ryan Coombs, Carlos A. Guerrero, David Marcoux, Qing Shi, Candice Lee Joe, Sanjeewa Rupasinghe, Jason J. Zhu, Srinivas Kalidindi, Sathasivam Shunmugaraj, Moorthy Kandasamy, Siva Sankar Bondigela, Rajappa Vaidyanathan, Shankar Tulsidas Tendulkar, Sankar Kuppusamy, Francisco González-Bobes
  • SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION
    Publication number: 20220127233
    Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.
    Type: Application
    Filed: November 12, 2021
    Publication date: April 28, 2022
    Inventors: Albert J. DELMONTE, Benjamin M. COHEN, Kenneth Joseph FRAUNHOFFER, Sergei KOLOTUCHIN, Francisco GONZALEZ-BOBES, Gregory Louis BEUTNER, Adam Joseph FREITAG, Michael Scott BULTMAN, Yu FAN, Prantik MAITY, Ian Scott YOUNG, Hilary Plake BECK, Maksim OSIPOV, Jay Patrick POWERS, Maureen Kay REILLY, Hunter Paul SHUNATONA, James Ross WALKER, Mikhail ZIBINSKY
  • Process for the preparation of N-((1R,2S,5R)-5-(-butylamino)-2-((S)-3-(7--butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrroldin-1-yl)cyclohexyl)acetamide
    Patent number: 11254679
    Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: February 22, 2022
    Assignee: Bristol-Myers Squibb Company
    Inventors: Burcu Selin Aytar, Alina Borovika, Collin Chan, Joerg Deerberg, Nathan R. Domagalski, Martin D. Eastgate, Yu Fan, Michael David Bengt Fenster, Robert V. Forest, Francisco Gonzalez-Bobes, Rebecca A. Green, Matthew R. Hickey, Nathaniel David Kopp, Thomas E. La Cruz, Kathleen Lauser, Hong Geun Lee, David K. Leahy, Helen Y. Luo, Thomas M. Razler, Scott A. Savage, Chris Sfouggatakis, Maxime C. D. Soumeillant, Serge Zaretsky, Bin Zheng, Ye Zhu
  • SYNTHETIC PROCESS
    Publication number: 20220048859
    Abstract: The invention generally relates to a process for preparing compounds, including Compound of Formula (I), useful as key intermediates in the preparation of compounds having ROR?t antagonist properties.
    Type: Application
    Filed: August 12, 2020
    Publication date: February 17, 2022
    Inventors: William P. Gallagher, John Ryan Coombs, Carlos A. Guerrero, David Marcoux, Qing Shi, Candice Lee Joe, Sanjeewa Rupasinghe, Jason J. Zhu, Srinivas Kalidindi, Sathasivam Shunmugaraj, Moorthy Kandasamy, Siva Sankar Bondigela, Rajappa Vaidyanathan, Shankar Tulsidas Tendulkar, Sankar Kuppusamy, Francisco González-Bobes
  • Substituted quinolinylcyclohexylpropanamide compounds and improved methods for their preparation
    Patent number: 11236048
    Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: February 1, 2022
    Assignee: Bristol-Myers Squibb Company
    Inventors: Albert J. Delmonte, Benjamin M. Cohen, Kenneth Joseph Fraunhoffer, Sergei Kolotuchin, Francisco Gonzalez-Bobes, Gregory Louis Beutner, Adam Joseph Freitag, Michael Scott Bultman, Yu Fan, Prantik Maity, Ian Scott Young, Hilary Plake Beck, Maksim Osipov, Jay Patrick Powers, Maureen Kay Reilly, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky
  • PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRAZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-OXOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE
    Publication number: 20200223852
    Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolodin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
    Type: Application
    Filed: July 19, 2018
    Publication date: July 16, 2020
    Inventors: Burcu Selin Aytar, Alina Borovika, Collin Chan, Joerg Deerberg, Nathan R. Domagalski, Martin D. Eastgate, Yu Fan, Michael David Bengt Fenster, Robert V. Forest, Francisco Gonzalez-Bobes, Rebecca A. Green, Matthew R. Hickey, Nathaniel David Kopp, Thomas E. La Cruz, Kathleen Lauser, Hong Geun Lee, David K. Leahy, Helen Y. Luo, Thomas M. Razler, Scott A. Savage, Chris Sfouggatakis, Maxime C.D. Soumeillant, Serge Zaretsky, Bin Zheng, Ye Zhu
  • SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION
    Publication number: 20200123109
    Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.
    Type: Application
    Filed: June 29, 2018
    Publication date: April 23, 2020
    Inventors: Albert J. DELMONTE, Benjamin M. COHEN, Kenneth Joseph FRAUNHOFFER, Sergei KOLOTUCHIN, Francisco GONZALEZ-BOBES, Gregory Louis BEUTNER, Adam Joseph FREITAG, Michael Scott BULTMAN, Yu FAN, Prantik MAITY, Ian Scott YOUNG, Hilary Plake BECK, Maksim OSIPOV, Jay Patrick POWERS, Maureen Kay REILLY, Hunter Paul SHUNATONA, James Ross WALKER, Mikhail ZIBINSKY
  • Process for preparing halogenated azaindole compounds using boroxine
    Patent number: 9908882
    Abstract: A process for preparing halogenated azaindole compounds makes use of stable reagents including a brominating reagent, a boroxine and a sulfonic anhydride to enhance the selectivity and yield of the final product. In addition, the process is associated with various other advantages, including the ability to recycle reagents, cost reduction, and improved manufacturability.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: March 6, 2018
    Assignee: ViiV HEALTHCARE UK (NO.4) LIMITED
    Inventors: Michael S. Bultman, Benjamin Cohen, Francisco Gonzalez-Bobes, Matthew R. Hickey
  • A PROCESS FOR PREPARING HALOGENATED AZAINDOLE COMPOUNDS USING PYBROP
    Publication number: 20170362262
    Abstract: A process for preparing halogenated azaindole compounds makes use of a brominating agent PyBroP, together with a dehydrating agent BSA to enhance the selectivity and improve the yield of the final product which is a piperazine prodrug useful as an antiviral.
    Type: Application
    Filed: December 17, 2015
    Publication date: December 21, 2017
    Inventors: Michael S. BULTMAN, Benjamin COHEN, Francisco GONZALEZ-BOBES, Matthew R. HICKEY
  • PROCESS FOR PREPARING HALOGENATED AZAINDOLE COMPOUNDS USING BOROXINE
    Publication number: 20170298064
    Abstract: A process for preparing halogenated azaindole compounds makes use of stable reagents including a brominating reagent, a boroxine and a sulfonic anhydride to enhance the selectivity and yield of the final product. In addition, the process is associated with various other advantages, including the ability to recycle reagents, cost reduction, and improved manufacturability.
    Type: Application
    Filed: December 17, 2015
    Publication date: October 19, 2017
    Inventors: Michael S. BULTMAN, Benjamin COHEN, Francisco GONZALEZ-BOBES, Matthew R. HICKEY
  • Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
    Patent number: 9273067
    Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for making and using these compounds in the treatment of HIV infection.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: March 1, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: B. Narasimhulu Naidu, Michael A. Walker, Margaret E. Sorenson, Manoj Patel, Zhizhen Barbara Zheng, John F. Kadow, Bin Zheng, Martin D. Eastgate, Ke Chen, Francisco Gonzalez-Bobes
  • PROCESSES FOR PREPARING TETRAHYDROISOQUINOLINES
    Publication number: 20160022675
    Abstract: Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and compositions comprising the tetrahydroisoquinolines and other compounds, e.g, intermediates and by-products of the processes described herein. Pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression are also disclosed.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 28, 2016
    Inventors: Francisco GONZALEZ-BOBES, David Alan CONLON, Paul C. LOBBEN, Justin Lockheart BURT, Joshua ENGSTROM, Carolyn S. WEI, Jason J. ZHU, Yu FAN
  • Pyrazolopyrimidine Macrocycles as Inhibitors of Human Immunodeficiency Virus Replication
    Publication number: 20150232481
    Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for making and using these compounds in the treatment of HIV infection.
    Type: Application
    Filed: February 11, 2015
    Publication date: August 20, 2015
    Inventors: B. Narasimhulu Naidu, Michael A. Walker, Margaret E. Sorenson, Manoj Patel, Zhizhen Barbara Zheng, John F. Kadow, Bin Zheng, Martin D. Eastgate, Ke Chen, Francisco Gonzalez-Bobes