Abstract: A computer system and method for extending parallelized asynchronous reinforcement learning to include agent modeling for training a neural network is described. Coordinated operation of plurality of hardware processors or threads is utilized such that each functions as a worker process that is configured to simultaneously interact with a target computing environment for local gradient computation based on a loss determination mechanism and to update global network parameters. The loss determination mechanism includes at least a policy loss term (actor), a value loss term (critic), and a supervised cross entropy loss. Variations are described further where the neural network is adapted to include a latent space to track agent policy features.

Abstract: The invention solves the problem of providing new therapies that are effective in the treatment of muscular dystrophies through the use of compositions comprising a compound capable of reducing the expression of miRNA-106b in muscle satellite stem cells of a human or animal subject with respect to the expression observed in the absence of the compound in said cells.

Abstract: A fixed-wing aerial vehicle includes: a fuselage with an on-board power supply; at least one fixed-wing or aerodynamic surface having at least one heater configured to be energized by the power supply, and having a superhydrophobic coating applied to at least a portion of the at least one fixed-wing or the aerodynamic surface that may be subject to icing; at least one capacitive sensor configured to detect ice formation on the at least one fixed-wing or aerodynamic surface; and a controller configured to selectively activate the at least one heater in response to detected ice formation.

Abstract: A method for automatically selecting a frequency band for transmission of a telemetry signal includes transforming acquired measurements from a time domain to a frequency domain to obtain a spectrum of measurements. The spectrum of measurements is processed to compute a total energy in band and a standard deviation of the power spectral density in band for a plurality of frequency bands. A ratio of the total energy in band to the standard deviation acquiring a plurality of measurements of transmitted telemetry signals and of the power spectral density in band is computed for at least two of the plurality of frequency bands. The frequency band having the highest computed ratio is selected and automatically downlinked to a downhole transmitter.

Abstract: The invention solves the problem of providing new therapies that are effective in the treatment of muscular dystrophies through the use of compositions comprising a compound capable of reducing the expression of miRNA-106b in muscle satellite stem cells of a human or animal subject with respect to the expression observed in the absence of the compound in said cells.

Abstract: The disclosure relates to a method for operating a chemically sensitive field-effect transistor, characterized in that the field effect transistor is operated with electrical pulses, the time interval between said pulses being selected to be greater than the duration of each individual electrical pulse.

Abstract: Pharmaceutical formulations in suppository form, containing thrombolytic agents, which are able to penetrate rectal mucous, for the treatment of acute hemorrhoid diseases and/or diseases of thrombotic origin.

Abstract: A method for automatically selecting a frequency band for transmission of a telemetry signal includes transforming acquired measurements from a time domain to a frequency domain to obtain a spectrum of measurements. The spectrum of measurements is processed to compute a total energy in band and a standard deviation of the power spectral density in band for a plurality of frequency bands. A ratio of the total energy in band to the standard deviation acquiring a plurality of measurements of transmitted telemetry signals and of the power spectral density in band is computed for at least two of the plurality of frequency bands. The frequency band having the highest computed ratio is selected and automatically downlinked to a downhole transmitter.

Abstract: A method for automatically selecting a frequency band for transmission of a mud pulse telemetry signal includes transforming acquired transducer measurements from a time domain to a frequency domain to obtain a spectrum of measurements. The spectrum of measurements is processed to compute a total energy in band and a standard deviation of the power spectral density in band for a plurality of frequency bands. A ratio of the total energy in band to the standard deviation acquiring a plurality of transducer measurements of transmitted mud pulse telemetry pressure pulses and of the power spectral density in band is computed for at least two of the plurality of frequency bands. The frequency band having the highest computed ratio is selected and automatically downlinked to a downhole mud pulse telemetry transmitter.

Abstract: A method for automatically selecting a frequency band for transmission of a mud pulse telemetry signal includes transforming acquired transducer measurements from a time domain to a frequency domain to obtain a spectrum of measurements. The spectrum of measurements is processed to compute a total energy in band and a standard deviation of the power spectral density in band for a plurality of frequency bands. A ratio of the total energy in band to the standard deviation acquiring a plurality of transducer measurements of transmitted mud pulse telemetry pressure pulses and of the power spectral density in band is computed for at least two of the plurality of frequency bands. The frequency band having the highest computed ratio is selected and automatically downlinked to a downhole mud pulse telemetry transmitter.

Abstract: A semiconductor component includes a substrate and a gallium nitride-containing first functional element which is implemented in the surface of the substrate. The substrate has a crystallographic (100) orientation.

Abstract: The disclosure relates to a method for operating a chemically-sensitive field-effect transistor which comprises a gate connection. At least one electrical field is generated at least during operation of said field-effect transistor and in at least one section thereof such that movable ions present at least in one field-effect transistor region that adjoins said gate connection are enriched and retained in predefinable regions of said field-effect transistor.

Abstract: The disclosure relates to a method for operating a chemically sensitive field-effect transistor, characterized in that the field effect transistor is operated with electrical pulses, the time interval between said pulses being selected to be greater than the duration of each individual electrical pulse.

Abstract: The present invention relates to the use of adenosine aspartate for differential activation of macrophages in inflammatory-fibrogenic processes and its reversal.

Abstract: A system for dividing a container into compartments has a divider that divides the container into compartments. The system also has a first support device configured to removably receive and support the divider in a first orientation that forms laterally adjacent compartments and a second support device configured to removably receive and support the divider in a second orientation that forms vertically adjacent compartments. The divider is received by either the first or second support device.

Abstract: A dielectric material for use in electrical energy storage devices includes at least two nanostructures which are each embedded in an electrically insulating matrix made of a material having a bandgap greater than a material of the nanostructures. A probability different from zero of charge carrier tunnelling in parallel to a direction of an electrical field that can be used from outside is set between the two nanostructures.