Patents by Inventor Francisco Humberto CRUZALEGUI

Francisco Humberto CRUZALEGUI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11685953
    Abstract: Biomarkers for the treatment of pathological conditions associated with the PI3K pathway, such as cancer, and methods of using inhibitors of upstream components of the PI3K pathway, such as PI3K-? inhibitors or AKT inhibitors, are described. In particular, there are described biomarkers for patient selection in the treatment of cancer, as well as methods of therapeutic treatment, diagnostic kits and methods of detection, wherein cancers that possess a mutation in an upstream component of the PI3K pathway (such as the PIK3CA gene and/or the AKT gene), and a wild-type MAP3K1 gene and MAP2K4 gene, are more likely to respond favourably to treatment with inhibitors of upstream components of the PI3K pathway.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: June 27, 2023
    Assignee: ASTRAZENECA AB
    Inventors: Alvaro Avivar Valderas, Francisco Humberto Cruzalegui, Kevin Hudson, Robert Kenneth McEwen
  • Publication number: 20210130901
    Abstract: Biomarkers for the treatment of pathological conditions associated with the PI3K pathway, such as cancer, and methods of using inhibitors of upstream components of the PI3K pathway, such as PI3K-? inhibitors or AKT inhibitors, are described. In particular, there are described biomarkers for patient selection in the treatment of cancer, as well as methods of therapeutic treatment, diagnostic kits and methods of detection, wherein cancers that possess a mutation in an upstream component of the PI3K pathway (such as the PIK3CA gene and/or the AKT gene), and a wild-type MAP3K1 gene and MAP2K4 gene, are more likely to respond favourably to treatment with inhibitors of upstream components of the PI3K pathway.
    Type: Application
    Filed: September 16, 2016
    Publication date: May 6, 2021
    Applicant: ASTRAZENECA AB
    Inventors: Alvaro AVIVAR VALDERAS, Francisco Humberto CRUZALEGUI, Kevin HUDSON, Robert Kenneth McEWEN
  • Publication number: 20180273528
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, and R5 are as defined in the description. Medicinal products containing the same which are useful in treating cancer, neurodegenerative disorders and metabolic disorders.
    Type: Application
    Filed: September 30, 2016
    Publication date: September 27, 2018
    Inventors: Balázs BÁLINT, András KOTSCHY, Melinda SIPOS, Csaba WÉBER, Nicolas FOLOPPE, David WALMSLEY, Michael BURBRIDGE, Francisco Humberto CRUZALEGUI
  • Publication number: 20180273538
    Abstract: Compounds of formula (I): wherein R1, R2, W3, W4, A1, and A2 are as defined in the description. Medicinal products containing the same which are useful in treating cancer, neurodegenerative disorders and metabolic disorders.
    Type: Application
    Filed: September 30, 2016
    Publication date: September 27, 2018
    Inventors: Andrea FIUMANA, Nicolas FOLOPPE, Stuart RAY, David WALMSLEY, András KOTSCHY, Michael BURBRIDGE, Francisco Humberto CRUZALEGUI