Patents by Inventor Francisco Javier LÓPEZ

Francisco Javier LÓPEZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9458105
    Abstract: This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: October 4, 2016
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Romyr Dominique, Francisco Javier Lopez-Tapia, Eric Mertz, Sung-Sau So
  • Publication number: 20160242527
    Abstract: Scent diffuser for electronic device cases, purses and other personal complements. It's made of a light mesh, a thin absorbent piece and a waterproof plastic sheet. It diffuses essence fragrances.
    Type: Application
    Filed: February 19, 2015
    Publication date: August 25, 2016
    Inventor: FRANCISCO JAVIER LOPEZ RIVERIEGO
  • Patent number: 9359345
    Abstract: This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: June 7, 2016
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Nicholas John Silvester Huby, Francisco Javier Lopez-Tapia, Sung-Sau So
  • Publication number: 20160144341
    Abstract: A process for producing surface postcrosslinked water-absorbing polymer particles, wherein the water-absorbing polymer particles are coated, before, during or after the surface postcrosslinking, with at least one basic salt of a trivalent metal cation and a monovalent carboxylic acid anion.
    Type: Application
    Filed: January 15, 2016
    Publication date: May 26, 2016
    Applicant: BASF SE
    Inventors: Patrick Hamilton, Olaf Hoeller, William G-J Chiang, Francisco Javier Lopez Villanueva, Joseph Grill
  • Publication number: 20160075612
    Abstract: The present invention relates to a process for producing polymer composites suitable for absorbing and storing aqueous liquids and to the polymer composites obtainable by this process. The invention further relates to the use of these polymer composites.
    Type: Application
    Filed: April 28, 2014
    Publication date: March 17, 2016
    Inventors: Francisco Javier LOPEZ VILLANUEVA, Tina MARK, Alexandra WIEDEMANN, Alexander WISSEMEIER, Michael SEUFERT, Jorge SANZ-GOMEZ, Alban GLASER
  • Patent number: 9279048
    Abstract: The use of water-absorbing polymer particles for dewatering feces, the water-absorbing polymer particles being obtainable by polymerizing a foamed monomer solution or suspension, drying the polymeric foam and grinding the dried foam.
    Type: Grant
    Filed: May 15, 2012
    Date of Patent: March 8, 2016
    Assignee: BASF SE
    Inventors: Francisco Javier Lopez Villanueva, Markus Linsenbühler, Matthias Weismantel, Bernd Siegel, Klaus Dieter Hörner, Sandra Engelhardt
  • Publication number: 20160002243
    Abstract: This application discloses compounds according to generic Formula (I) wherein all variables are defined as described herein, which inhibit BTK. The compounds disclosed herein are useful to modulate the activity of BTK and treat diseases associated with excessive BTK activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.
    Type: Application
    Filed: March 3, 2014
    Publication date: January 7, 2016
    Inventors: Javier De Vicente Fidalgo, Romyr Dominique, Francisco Javier Lopez-Tapia, Sung-Sau So
  • Publication number: 20160002206
    Abstract: This application discloses compounds according to generic Formula I: (I) wherein all variables are defined as described herein, which inhibit BTK. The compounds disclosed herein are useful to modulate the activity of BTK and treat diseases associated with excessive BTK activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
    Type: Application
    Filed: March 3, 2014
    Publication date: January 7, 2016
    Inventors: Christine E. Brotherton-Pleiss, Rama K. Kondru, Francisco Javier Lopez-Tapia, Yan Lou
  • Publication number: 20150376166
    Abstract: This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit BTK. The compounds disclosed herein are useful to modulate the activity of BTK and treat diseases associated with excessive BTK activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
    Type: Application
    Filed: March 3, 2014
    Publication date: December 31, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventor: Francisco Javier Lopez-Tapia
  • Publication number: 20150353534
    Abstract: This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
    Type: Application
    Filed: December 9, 2013
    Publication date: December 10, 2015
    Inventors: Nicholas John Silvester Huby, Francisco Javier Lopez-Tapia, Sung-Sau So
  • Publication number: 20150290192
    Abstract: This application discloses the Btk inhibitor compounds 6-tert-Butyl-8-fluoro-2-{3-hydroxymethyl-4-[1-methyl-5-(1?-methyl-1?,2?,3?,4?,5?,6?-hexahydro-[3,4?]bipyridinyl-6-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-pyridin-2-yl}-2H-phthalazin-1-one, 2-(2-{3-[5-(5-Azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl]-2-hydroxy methyl-phenyl}-8-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile, and 6-tert-Butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxy-ethylamino)-methyl]-pyridin-2-ylamino}-6-oxo-1,6-dihydro-pyridin-3-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one, formulations thereof, and methods of treatment of asthma, as described herein.
    Type: Application
    Filed: November 27, 2013
    Publication date: October 15, 2015
    Inventors: Raman Mahadevan Iyer, Dramane Ibrahim Laine, Francisco Javier Lopez-Tapia, Jonathan E. Phillips, Christopher Stevenson
  • Publication number: 20150291525
    Abstract: This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
    Type: Application
    Filed: November 13, 2013
    Publication date: October 15, 2015
    Inventors: Romyr Dominique, Francisco Javier Lopez-Tapia, Eric Mertz, Sung-Sau So
  • Publication number: 20150284394
    Abstract: This application discloses compounds according to generic Formula I wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
    Type: Application
    Filed: October 23, 2013
    Publication date: October 8, 2015
    Inventors: Niala Bhagirath, Romyr Dominique, Joshua Kennedy-Smith, Francisco Javier Lopez-Tapia, Eric Mertz, Qi Qiao, Sung-Sau So
  • Patent number: 9120878
    Abstract: A process for preparing water-absorbing polymeric foams by polymerization of a foamed aqueous monomer solution or suspension, comprising an ethylenically unsaturated monomer which bears acid groups and may be at least partly neutralized, a crosslinker, a photoinitiator and a surfactant.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: September 1, 2015
    Assignee: BASF SE
    Inventors: Francisco Javier Lopez Villanueva, Markus Linsenbühler, Matthias Weismantel, Bernd Siegel, Timo Baumgaertner, Michael Fastner
  • Publication number: 20150210704
    Abstract: This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
    Type: Application
    Filed: September 10, 2013
    Publication date: July 30, 2015
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christine E. Brotherton-Pleiss, Ramona Hilgenkamp, Rama K. Kondru, Francisco Javier Lopez-Tapia, Yan Lou
  • Patent number: 9073040
    Abstract: The present invention relates to a process for producing water-absorbent polymer particles by polymerizing droplets of a monomer solution in a surrounding heated gas phase and flowing the gas cocurrent through the polymerization chamber, wherein the temperature of the gas leaving the polymerization chamber is 130° C. or less, the gas velocity inside the polymerization chamber is at least 0.5 m/s, and the droplets are generated by using a droplet plate having a multitude of bores.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: July 7, 2015
    Assignee: BASF SE
    Inventors: Rainer Dobrawa, Thomas Daniel, Uwe Stueven, Marco Krüger, Francisco Javier Lopez Villanueva, Norbert Herfert, Karin Flore, Stefan Blei, Michael A. Mitchell
  • Patent number: 9056302
    Abstract: The present invention relates to microcapsules comprising a capsule core and a capsule wall, obtainable by a process comprising the free-radical polymerization of an oil-in-water emulsion which comprises the following constituents: 30 to 90% by weight based on the total weight of the monomers of one or more monomers (monomers I) from the group comprising C1-C24-alkyl esters of acrylic acid and/or methacrylic acid, acrylic acid, methacrylic acid, maleic acid, fumaric acid and itaconic acid 10 to 70% by weight based on the total weight of the monomers of one or more ethylenically unsaturated crosslinkers (monomers II), where at least 10% by weight, based on the total weight of the monomers I, II and III, is a highly branched polymeric crosslinker, 0 to 30% by weight based on the total weight of the monomers of one or more monounsaturated monomers (monomer III), which are different from the monomers I, and a hydrophobic core material, to a process for their preparation and to their use.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: June 16, 2015
    Assignee: BASF SE
    Inventors: Marc Rudolf Jung, Francisco Javier Lopez Villanueva, Tina Schroeder-Grimonpont, Monika Haberecht, Bernd Bruchmann
  • Patent number: 8987545
    Abstract: A feminine hygiene absorbent article comprising water-absorbing polymer particles, obtainable by polymerization of a foamed monomer solution or suspension, drying, grinding and classification.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: March 24, 2015
    Assignee: The Procter & Gamble Company
    Inventors: Brian Francis Gray, Achille Di Cintio, Giovanni Carlucci, Francisco Javier Lopez Villanueva, Markus Linsenbuehler, Matthias Weismantel, Bernd Adolf Siegel
  • Publication number: 20150065594
    Abstract: A process for preparing water-absorbing polymer particles, comprising polymerisation of a foamed aqueous monomer solution or suspension, drying, grinding and classification, whereas the process further comprising adjusting the amount of foaming agent in the aqueous monomer solution by admixing the aqueous monomer solution with a foaming agent of 1% to 15% by weight based on the amount of ethylenically unsaturated monomer and keeping the solution on a pressure of 6 bar to 15 bar and then expanding the solution.
    Type: Application
    Filed: August 11, 2014
    Publication date: March 5, 2015
    Inventors: Martin Wendker, Markus Braun, Roland Krauss, Francisco Javier Lopez Villanueva
  • Patent number: 8940741
    Abstract: This application discloses 6-(2-Hydroxymethyl-phenyl)-2-methyl-2H-pyridazin-3-one derivatives according to generic Formula I: wherein, variables X, R, and Y4, are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation, such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: January 27, 2015
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Steven Joseph Berthel, Roland Joseph Billedeau, Christine E. Brotherton-Pleiss, Fariborz Firooznia, Stephen Deems Gabriel, Xiaochun Han, Ramona Hilgenkamp, Saul Jaime-Figueroa, Buelent Kocer, Francisco Javier Lopez-Tapia, Yan Lou, Lucja Orzechowski, Timothy D. Owens, Jenny Tan, Peter Michael Wovkulich