Patents by Inventor Francisco Javier Lopez-Tapia

Francisco Javier Lopez-Tapia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20120295885
    Abstract: This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
    Type: Application
    Filed: May 16, 2012
    Publication date: November 22, 2012
    Inventors: Roland Joseph Billedeau, Rama K. Kondru, Francisco Javier Lopez-Tapia, Yan Lou, Timothy D. Owens, Yimin Qian, Sung-Sau So, Kshitij C. Thakkar, Jutta Wanner
  • Dihydropyridone amidesas P2Xmodulators
    Patent number: 8288552
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: October 16, 2012
    Assignee: Roche Palo Alto LLC
    Inventors: Jacob Berger, Joan Marie Caroon, Francisco Javier Lopez-Tapia, Dov Nitzan, Keith Adrian Murray Walker, Shu-Hai Zhao
  • Dihydropyridone amides as P2Xmodulators
    Patent number: 8163929
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, R1, R2, R3, R4, R5 and R6 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: April 24, 2012
    Assignee: Roche Palo Alto LLC
    Inventors: Jacob Berger, Christine E. Brotherton-Pleiss, Francisco Javier Lopez-Tapia, Keith Adrian Murray Walker, Shu-Hai Zhao
  • Dihydropyridone amides as P2X7 modulators
    Patent number: 8153808
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: April 10, 2012
    Assignee: Roche Palo Alto LLC
    Inventors: Francisco Javier Lopez-Tapia, Keith Adrian Murray Walker, Shu-Hai Zhao
  • Dihydropyridone ureas as P2Xmodulators
    Patent number: 8153809
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: April 10, 2012
    Assignee: Roche Palo Alto LLC
    Inventors: Christine E. Brotherton-Pleiss, Joan Marie Caroon, Francisco Javier Lopez-Tapia, Dov Nitzan, Keith Adrian Murray Walker
  • Inhibitors of Bruton's Tyrosine Kinase
    Publication number: 20120040949
    Abstract: This application discloses 6-(2-Hydroxymethyl-phenyl)-2-methyl-2H-pyridazin-3-one derivatives according to generic Formula I: wherein, variables X, R, and Y4, are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation, such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
    Type: Application
    Filed: August 11, 2011
    Publication date: February 16, 2012
    Inventors: Steven Joseph Berthel, Roland Joseph Billedeau, Christine E. Brotherton-Pleiss, Fariborz Firooznia, Stephen Deems Gabriel, Xiaochun Han, Ramona Hilgenkamp, Saul Jaime-Figueroa, Buelent Kocer, Francisco Javier Lopez-Tapia, Yan Lou, Lucja Orzechowski, Timothy D. Owens, Jenny Tan, Peter Michael Wovkulich
  • FUSED TRIAZOLE AMINES AS P2X7 MODULATORS
    Publication number: 20110071143
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, and R3 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Application
    Filed: September 15, 2010
    Publication date: March 24, 2011
    Inventors: Christine E. Brotherton-Pleiss, Ralph New Harris, III, Bradley E. Loe, Francisco Javier Lopez-Tapia, Pankaj D. Rege, David Bruce Repke, Russell Stephen Stabler, Keith Adrian Murray Walker
  • DIHYDROPYRIMIDONE AMIDES AS P2X7 MODULATORS
    Publication number: 20110028502
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5, Ra and Rb are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Application
    Filed: July 30, 2010
    Publication date: February 3, 2011
    Inventors: Christine E. Brotherton-Pleiss, Joan Marie Caroon, Francisco Javier Lopez-Tapia, Keith Adrian Murray Walker
  • Arylsulfonyl pyrrolidines as 5-HTinhibitors
    Patent number: 7776910
    Abstract: Compounds of the formula I: wherein m, n, Ar, R1 and R2 are as defined herein. Methods of making the compounds and using the compounds are disclosed.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: August 17, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Francisco Javier Lopez-Tapia, Lee Edwin Lowrie, Jr., Dov Nitzan
  • Arylsulfonyl chromans as 5-HTinhibitors
    Patent number: 7754759
    Abstract: Compounds of the formula I: wherein m, n, p, X, Ar, R1, R2, R3, R4 and R5 are as defined herein. Methods of making the compounds and using the compounds for treatment of 5-HT6 receptor-mediated diseases are disclosed.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: July 13, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Jacob Berger, Joan Marie Caroon, Francisco Javier Lopez-Tapia, Lee Edwin Lowrie, Jr., Dov Nitzan, Shu-Hai Zhao
  • DIHYDROPYRIDONE AMIDESAS P2X7 MODULATORS
    Publication number: 20100160389
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Application
    Filed: December 15, 2009
    Publication date: June 24, 2010
    Inventors: Jacob Berger, Joan Marie Caroon, Francisco Javier Lopez-Tapia, Dov Nitzan, Keith Adrian Murray Walker, Shu-Hai Zhao
  • DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS
    Publication number: 20100160384
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, R1, R2, R3, R4, R5 and R6 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Application
    Filed: December 15, 2009
    Publication date: June 24, 2010
    Inventors: Jacob Berger, Christine E. Brotherton-Pleiss, Francisco Javier Lopez-Tapia, Keith Adrian Murray Walker, Shu-Hai Zhao
  • DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS
    Publication number: 20100160373
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Application
    Filed: December 15, 2009
    Publication date: June 24, 2010
    Inventors: Jacob Berger, Joan Marie Caroon, Nancy Elisabeth Krauss, Keith Adrian Murray Walker, Shu-Hai Zhao, Francisco Javier Lopez-Tapia
  • DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS
    Publication number: 20100160388
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Application
    Filed: December 15, 2009
    Publication date: June 24, 2010
    Inventors: Christine E. Brotherton-Pleiss, Joan Marie Caroon, Francisco Javier Lopez-Tapia
  • DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS
    Publication number: 20100160387
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Application
    Filed: December 14, 2009
    Publication date: June 24, 2010
    Inventors: Francisco Javier Lopez-Tapia, Keith Adrian Murray Walker, Shu-Hai Zhao
  • Arylsulfonyl pyrrolidines as 5-HT6 inhibitors
    Publication number: 20080167361
    Abstract: Compounds of the formula I: wherein m, n, Ar, R1 and R2 are as defined herein. Methods of making the compounds and using the compounds are disclosed.
    Type: Application
    Filed: November 8, 2007
    Publication date: July 10, 2008
    Inventors: Francisco Javier Lopez-Tapia, Lee Edwin Lowrie, Dov Nitzan
  • Substituted aryl amides as IP antagonists
    Patent number: 7279498
    Abstract: Compounds effective as IP receptor modulators, particularly IP receptor antagonists, that are of the formula I: wherein A, R1, R2, R3 and R4 are as defined in the specification; and individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. Also disclosed are pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
    Type: Grant
    Filed: September 1, 2005
    Date of Patent: October 9, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Paul Francis Keitz, Alam Jahangir, Francisco Javier Lopez-Tapia, Counde O'Yang
  • Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists
    Patent number: 7244738
    Abstract: Compounds represented by Formula I: which are useful as are alpha-1A/B adrenoceptor antagonists, to methods of treating conditions associated with the activity of alpha-1A/B adrenoceptors, and to methods of making said compounds, wherein Ar, Z, R, R?, R5 and R10 are as defined herein.
    Type: Grant
    Filed: July 2, 2004
    Date of Patent: July 17, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Terrence Joseph Connolly, Paul Francis Keitz, Eun Kyung Lee, Jim Li, Francisco Javier Lopez-Tapia, Patrick Finbar McGarry, Chris Richard Melville, Dov Nitzan, Counde O'Yang, Fernando Padilla, Klaus Kurt Weinhardt
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 7141584
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: November 28, 2006
    Assignee: Roche Palo Alto LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • Substituted arylamides as IP antagonists
    Patent number: 6998414
    Abstract: Compounds effective as IP receptor modulators, particularly IP receptor antagonists, that are of the formula I: wherein A, R1, R2, R3 and R4 are as defined in the specification; and individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. Also disclosed are pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: February 14, 2006
    Assignee: Roche Palo Alto LLC
    Inventors: Paul Francis Keitz, Alam Jahangir, Francisco Javier Lopez-Tapia, Counde O'Yang