Patents by Inventor Francisco Javier Ramos Lima

Francisco Javier Ramos Lima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tricyclic compounds for use as kinase inhibitors
    Patent number: 9682991
    Abstract: There is provided compounds of formula (I), wherein R1, R2, R3 and R4 have meanings given in the description (and which compounds are optionally substituted as indicated in the description), and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. There is also provided combinations comprising the compounds of formula (I).
    Type: Grant
    Filed: December 31, 2010
    Date of Patent: June 20, 2017
    Assignee: FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
    Inventors: Joaquín Pastor Fernández, Francisco Javier Ramos Lima, Ana Isabel Hernandez Higueras, Sonia Martínez González, Jose Ignacio Martín Hernando, Carl-Gustave Pierre Saluste, Esther Gonzalez Cantalapiedra, Carmen Blanco Aparicio, Antonio Rodríguez Hergueta, Ana Maria Garcia Collazo, Antonio Salgado Serrano, Beatriz Noya Marino
  • Inhibitors of PI3 kinase
    Patent number: 9073927
    Abstract: There is provided compounds of formula (I), wherein A1, A4, A4a, A5, B1, B1a, B2, B2a, B3, B3a, B4, B4a and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PI3-K and/or mTOR) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: July 7, 2015
    Assignee: FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
    Inventors: Joaquin Pastor Fernández, Sonia Martinez Gonzalez, Rosa Maria Álvarez Escobar, Antonio Rodriguez Hergueta, Jose Ignacio Martin Hernando, Francisco Javier Ramos Lima
  • NEW BICYCLIC COMPOUNDS AS PI3-K AND MTOR INHIBITORS
    Publication number: 20130131057
    Abstract: There is provided compounds of formula (I), wherein A1, A4, A4a, A5, B1, B1a, B2, B2a, B3, B3a, B4, B4a and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PI3-K and/or mTOR) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.
    Type: Application
    Filed: May 13, 2011
    Publication date: May 23, 2013
    Applicant: CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO
    Inventors: Joaquin Pastor Fernández, Sonia Martínez Gonzalez, Antonlo Rodriguez Hergueta, Francisco Javier Ramos Lima, Rosa Maria Alvarez Escobar, Ana Isabel Higueras Hernandez
  • Tricyclic Compounds for Use as Kinase Inhibitors
    Publication number: 20130065881
    Abstract: There is provided compounds of formula (I), wherein R1, R2, R3 and R4 have meanings given in the description (and which compounds are optionally substituted as indicated in the description), and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. There is also provided combinations comprising the compounds of formula (I).
    Type: Application
    Filed: December 31, 2010
    Publication date: March 14, 2013
    Applicant: CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS
    Inventors: Joaquin Pastor Fernandez, Francisco Javier Ramos Lima, Ana Isabel Hernandez Higueras, Sonia Martinez Gonzalez, Jose Ignacio Martin Hernando, Carl-Gustave Pierre Saluste, Esther Gonzalez Cantalapiedra, Carmen Blanco Aparicio, Antonio Rodriguez Hergueta, Ana Maria Garcia Collazo, Antonio Salgado Serrano, Beatriz Noya Marino
  • Imidazopyridazines for Use as Protein Kinase Inhibitors
    Publication number: 20110046127
    Abstract: There is provided compounds of formula (I): wherein Z, M, R1, X, R3, R4 and R5 have meanings given in the description, an pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein kinase (e.g. a PIM family kinase or PI3-K) is desired and/or required, an particularly in the treatment of cancer.
    Type: Application
    Filed: November 10, 2008
    Publication date: February 24, 2011
    Inventors: Paolo Pevarello, Ana Maria Garcia Collazo, Antonio Rodriguez Hergueta, Carl-Gustaf Pierre Saluste, Francisco Javier Ramos Lima, Esther Gonzalez Cantalapiedra, Julen Oyarzabal Santamarina