Patents by Inventor Francisco Palomo Nicolau

Francisco Palomo Nicolau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thiadiazolidinediones as GSK-3 inhibitors
    Patent number: 9469618
    Abstract: The present invention relates to new thiadiazolidinediones of formula (I), or any pharmaceutically acceptable salt, solvate or prodrug thereof, and its use in the treatment of a disease in which glycogen synthase kinase 3 (GSK-3) is involved, particularly neurodegenerative diseases, inflammatory and autoimmune diseases and cardiovascular disorders. Additionally, there is provided a process for preparing such compounds, as well as pharmaceutical compositions comprising them.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: October 18, 2016
    Assignee: ASD THERAPEUTICS PARTNERS, LLC
    Inventors: Miguel Medina Padilla, Juan Manuel Domínguez Correa, Javier de Cristobal Blanco, Ana Fuertes Huerta, Jorge Sánchez-Quesada, Javier López Ogalla, Susana Herrero Santos, María Ángeles Pérez de la Cruz Moreno, Olga Martínez Montero, Beatriz Rodríguez Salguero, Francisco Palomo Nicolau
  • THIADIAZOLIDINEDIONES AS GSK-3 INHIBITORS
    Publication number: 20160257660
    Abstract: The present invention relates to new thiadiazolidinediones of formula (I), or any pharmaceutically acceptable salt, solvate or prodrug thereof, and its use in the treatment of a disease in which glycogen synthase kinase 3 (GSK-3) is involved, particularly neurodegenerative diseases, inflammatory and autoimmune diseases and cardiovascular disorders. Additionally, there is provided a process for preparing such compounds, as well as pharmaceutical compositions comprising them.
    Type: Application
    Filed: May 16, 2016
    Publication date: September 8, 2016
    Inventors: Miguel MEDINA PADILLA, Juan Manuel DOMÍNGUEZ CORREA, Javier DE CRISTOBAL BLANCO, Ana FUERTES HUERTA, Jorge SÁNCHEZ-QUESADA, Javier LÓPEZ OGALLA, Susana HERRERO SANTOS, María Ángeles PÉREZ DE LA CRUZ MORENO, Olga MARTÍNEZ MONTERO, Beatriz RODRÍGUEZ SALGUERO, Francisco PALOMO NICOLAU
  • Thiadiazolidinediones as GSK-3 inhibitors
    Patent number: 9371299
    Abstract: The present invention relates to new thiadiazolidinediones of formula (I), or any pharmaceutically acceptable salt, solvate or prodrug thereof, and its use in the treatment of a disease in which glycogen synthase kinase 3 (GSK-3) is involved, particularly neurodegenerative diseases, inflammatory and autoimmune diseases and cardiovascular disorders. Additionally, there is provided a process for preparing such compounds, as well as pharmaceutical compositions comprising them.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: June 21, 2016
    Assignee: ASD THERAPEUTICS PARTNERS, LLC
    Inventors: Miguel Medina Padilla, Juan Manuel Domínguez Correa, Javier De Cristobal Blanco, Ana Fuertes Huerta, Jorge Sánchez-Quesada, Javier López Ogalla, Susana Herrero Santos, María Ángeles Pérez de la Cruz Moreno, Olga Martínez Montero, Beatriz Rodríguez Salguero, Francisco Palomo Nicolau
  • Bipyridine sulfonamide derivatives for the treatment of neurodegenerative diseases or conditions
    Patent number: 9284296
    Abstract: The present invention relates to novel bipyridine sulfonamide derivatives of formula (I) and their use for the treatment and/or prophylaxis of a neurodegenerative disease or condition, particularly Alzheimers disease (AD), a cardiovascular disease or a pathology involving ischemia. Additionally, processes for preparing such derivatives and pharmaceutical compositions comprising them are provided.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: March 15, 2016
    Assignee: AUBERGINE PHARMACEUTICALS LLC
    Inventors: Francisco Palomo Nicolau, Jorge Sánchez-Quesada, Javier López Ogalla, Félix Hernández Juan, Javier Villasante Prieto, Miguel Medina Padilla, Ana Fuertes Huerta, Juan Manuel Dominguez Correa, Susana Herrero Santos, Mercedes Alonso Cascón
  • THIADIAZOLIDINEDIONES AS GSK-3 INHIBITORS
    Publication number: 20150038538
    Abstract: The present invention relates to new thiadiazolidinediones of formula (I), or any pharmaceutically acceptable salt, solvate or prodrug thereof, and its use in the treatment of a disease in which glycogen synthase kinase 3 (GSK-3) is involved, particularly neurodegenerative diseases, inflammatory and autoimmune diseases and cardiovascular disorders. Additionally, there is provided a process for preparing such compounds, as well as pharmaceutical compositions comprising them.
    Type: Application
    Filed: February 22, 2013
    Publication date: February 5, 2015
    Applicant: ASD THERAPEUTICS PARTNERS LLC
    Inventors: Miguel Medina Padilla, Juan Manuel Domínguez Correa, Javier De Cristobal Blanco, Ana Fuertes Huerta, Jorge Sánchez-Quesada, Javier López Ogalla, Susana Herrero Santos, María Ángeles Pérez De La Cruz Moreno, Olga Martínez Montero, Beatriz Rodríguez Salguero, Francisco Palomo Nicolau
  • BIPYRIDINE SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES OR CONDITIONS
    Publication number: 20140005195
    Abstract: The present invention relates to novel bipyridine sulfonamide derivatives of formula (I) and their use for the treatment and/or prophylaxis of a neurodegenerative disease or condition, particularly Alzheimers disease (AD), a cardiovascular disease or a pathology involving ischemia. Additionally, processes for preparing such derivatives5 and pharmaceutical compositions comprising them are provided.
    Type: Application
    Filed: November 21, 2011
    Publication date: January 2, 2014
    Applicant: Noscira, S.A.
    Inventors: Francisco Palomo Nicolau, Jorge Sánchez-Quesada, Javier López Ogalla, Félix Hernández Juan, Javier Villasante Prieto, Miguel Medina Padilla, Ana Fuertes Huerta, Juan Manuel Dominguez Correa, Susan Herrero Santos, Mercedes Alonso Cascón
  • Process For Obtaining Levofloxacin Free From Salts
    Publication number: 20090069560
    Abstract: This invention relates to a process for obtaining levofloxacin free from salts. In this process the starting product used is the compound (V), alkaline hydrolysis of which within a water-(C1-C4)alcohol mixture, and subsequent neutralisation and separation of the salts, leads to levofloxacin free from salts, without need to carry out any final step of extraction and without using halogenated solvents. One characteristic of the process described is that no extractions are necessary in the final step of the process.
    Type: Application
    Filed: December 15, 2005
    Publication date: March 12, 2009
    Applicant: Quimica Sintetica, S.A.
    Inventors: Francisco Palomo Nicolau, Antonio Cosme Gomez, Rafael Martin Sanchez
  • Crystalline form of gatifloxacin
    Publication number: 20070032505
    Abstract: The present invention relates to a crystalline form of gatifloxacin obtainable by a process that comprises recrystallisation of the crude gatifloxacin in methanol and which is stable with a water content ranging between 2.5 and 4.5% by weight, to a process for preparing it and to the use thereof as an active substance in the preparation of pharmaceutical formulations.
    Type: Application
    Filed: November 5, 2004
    Publication date: February 8, 2007
    Inventors: Cosme Gomez, Javier Villasante Prieto, Francisco Palomo Nicolau
  • Addition salts of azithromycin and citric acid and process for preparing them
    Publication number: 20070021359
    Abstract: Said addition salts have a molar ratio between azithromycin and citric acid such as to provide a pH comprised between 4.0 and 8.0 in a 10% aqueous solution. The process for preparing said salts comprises: a) dissolving azithromycin in a solvent or mixture of solvents; b) adding citric acid; and c) isolating the product obtained by crystallisation. The addition salts of azithromycin and citric acid are stable and soluble in aqueous medium, being useful antibacterial and antiprotozoan agents.
    Type: Application
    Filed: May 26, 2004
    Publication date: January 25, 2007
    Inventors: Antonio Cosme Gomez, Francisco Palomo Nicolau
  • Enzymatic process for the preparation of an intermediate compound and use thereof for the synthesis of tamsulosin hydrochloride
    Publication number: 20060148046
    Abstract: The present invention relates to a process of enantioselective enzymatic acylation for the preparation of (R)-2-halo-N-[2-(4-methoxyphenyl)-1-methyl-ethyl] acetamide compounds, of formula III, in which X?Cl, Br, I. These compounds (III) are useful as intermediates in the synthesis of tamsulosin hydrochloride.
    Type: Application
    Filed: March 14, 2005
    Publication date: July 6, 2006
    Inventors: Javier Villasante Prieto, Francisco Palomo Nicolau
  • Preparation of crystalline polymorphs of fosinopril sodium
    Publication number: 20050010054
    Abstract: A new procedure is described for the selective preparation of crystalline polymorphs A and B of fosinopril, especially polymorph A. The procedure described allows to avoid the use of significant quantities of water, thus resulting in a lower risk of hydrolytic degradations of the active ingredient.
    Type: Application
    Filed: November 19, 2002
    Publication date: January 13, 2005
    Inventors: Sandra Gallego Pato, Antonio Palomo Coll, Francisco Palomo Nicolau