Patents by Inventor Franciscus B. G. Benneker

Franciscus B. G. Benneker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amlodipine free base
    Patent number: 7335380
    Abstract: Amlodipine free base can be formulated into a convenient oral dosage form, especially a tablet, without excessive stickiness or tablet punch residue. The amlodipine free base can be crystalline Form I or a novel Form II. Methods of making and using the amlodipine free base are set forth.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: February 26, 2008
    Assignee: Synthon IP Inc.
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker, Rolf Keltjens
  • Amide derivative of amlodipine
    Patent number: 7199247
    Abstract: A derivative of amlodipine having the following formula is useful as a pharmaceutical, either alone or in combination with amlodipine, in treating angina and hypertension.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: April 3, 2007
    Assignee: Synthon IP Inc.
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker
  • Amide derivative of amlodipine
    Patent number: 7115638
    Abstract: A derivative of amlodipine having the following formula is useful as a pharmaceutical, either alone or in combination with amlodipine, in treating angina and hypertension
    Type: Grant
    Filed: May 12, 2003
    Date of Patent: October 3, 2006
    Assignee: Synthon IP Inc.
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker
  • Process for making amlodipine, derivatives thereof, and precursors therefor
    Patent number: 6858738
    Abstract: Amlodipine and related analogues thereof are prepared by the following general reaction scheme: R1 and R2 each independently represent a C1-C4 alkyl group. The process provides for the formation of compounds of formula (1) in good yield and purity. Further, the compounds of formula (1) can be used as calcium channel blockers or as reference standards or reference markers for checking the purity of amlodipine.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: February 22, 2005
    Assignee: Synthon BV
    Inventors: Theodorus H. A. Peters, Franciscus B. G. Benneker, Pavel Slanina, Jiri Bartl
  • Process for making amlodipine, derivatives thereof, and precursors therefor
    Publication number: 20030220501
    Abstract: Amlodipine and related analogues thereof are prepared by the following general reaction scheme: 1
    Type: Application
    Filed: May 8, 2003
    Publication date: November 27, 2003
    Inventors: Theodorus H. A. Peters, Franciscus B. G. Benneker, Pavel Slanina, Jiri Bartl
  • Process for making amlodipine
    Patent number: 6653481
    Abstract: Amlodipine and related analogues thereof are prepared by the following general reaction scheme: R1 and R2 each independently represent a C1-C4 alkyl group. The process provides for the formation of compounds of formula (1) in good yield and purity. Further, the compounds of formula (1) can be used as calcium channel blockers or as reference standards or reference markers for checking the purity of amlodipine.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: November 25, 2003
    Assignee: Synthon BV
    Inventors: Theodorus H. A. Peters, Franciscus B. G. Benneker, Pavel Slanina, Jiri Bartl
  • Amide derivative of amlodipine
    Publication number: 20030204093
    Abstract: A derivative of amlodipine having the following formula is useful as a pharmaceutical, either alone or in combination with amlodipine, in treating angina and hypertension.
    Type: Application
    Filed: May 12, 2003
    Publication date: October 30, 2003
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker
  • Process for making amlodipine maleate
    Publication number: 20030199559
    Abstract: A process for making amlodipine maleate comprises reacting amlodipine or an acid addition salt thereof with maleic acid under an acidic environment to form an amlodipine maleate product. The process allows for the formation of amlodipine maleate substantially free from amlodipine aspartate.
    Type: Application
    Filed: May 8, 2003
    Publication date: October 23, 2003
    Inventors: Franciscus B. G. Benneker, Pavel Slanina, Frantisek Picha
  • Amide derivative of amlodipine
    Patent number: 6602893
    Abstract: A derivative of amlodipine having the following formula is useful as a pharmaceutical, either alone or in combination with amlodipine, in treating angina and hypertension.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: August 5, 2003
    Assignee: Synthon BV
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker
  • Process for making amlodipine maleate
    Patent number: 6600047
    Abstract: A process for making amlodipine maleate comprises reacting amlodipine or an acid addition salt thereof with maleic acid under an acidic environment to form an amlodipine maleate product. The process allows for the formation of amlodipine maleate substantially free from amlodipine aspartate.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: July 29, 2003
    Assignee: Synthon BV
    Inventors: Franciscus B. G. Benneker, Pavel Slanina, Frantisek Picha
  • Amlodipine fumarate
    Patent number: 6518288
    Abstract: Amlodipine fumarate salt compounds are useful as calcium channel blockers and in treating or preventing angina or hypertension. The fumarate salts avoid the formation of certain potential impurities that have been found to be associated with amlodipine maleate.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: February 11, 2003
    Assignee: Synthon BV
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker, Frantisek Picha
  • Amlodipine free base
    Publication number: 20030022922
    Abstract: Amlodipine free base can be formulated into a convenient oral dosage form, especially a tablet, without excessive stickiness or tablet punch residue. The amlodipine free base can be crystalline Form I or a novel Form II. Methods of making and using the amlodipine free base are set forth.
    Type: Application
    Filed: December 21, 2001
    Publication date: January 30, 2003
    Inventors: Jacobus M. Lemmens, Theodorus H.A. Peters, Franciscus B.G. Benneker, Rolf Keltjens
  • Aspartate derivative of amlodipine
    Patent number: 6479525
    Abstract: An amlodipine derivative having the following formula is useful, either alone or in combination with amlodipine, as a pharmaceutical in treating angina and hypertension.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: November 12, 2002
    Assignee: Synthon BV
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker
  • Process for making amlodipine, derivatives therof, and precursors therefor
    Publication number: 20020143046
    Abstract: Amlodipine and related analogues thereof are prepared by the following general reaction scheme: 1
    Type: Application
    Filed: August 27, 2001
    Publication date: October 3, 2002
    Inventors: Theodorus H. A. Peters, Franciscus B. G. Benneker, Pavel Slanina, Jiri Bartl
  • Aspartate derivative of amlodipine
    Publication number: 20020128296
    Abstract: An amlodipine derivative having the following formula is useful, either alone or in combination with amlodipine, as a pharmaceutical in treating angina and hypertension.
    Type: Application
    Filed: August 27, 2001
    Publication date: September 12, 2002
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B.G. Benneker
  • Amide derivative of amlodipine
    Publication number: 20020123518
    Abstract: A derivative of amlodipine having the following formula is useful as a pharmaceutical, either alone or in combination with amlodipine, in treating angina and hypertension.
    Type: Application
    Filed: August 27, 2001
    Publication date: September 5, 2002
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker
  • Amlodipine fumarate
    Publication number: 20020123519
    Abstract: Amlodipine fumarate salt compounds are useful as calcium channel blockers and in treating or preventing angina or hypertension. The fumarate salts avoid the formation of certain potential impurities that have been found to be associated with amlodipine maleate.
    Type: Application
    Filed: August 27, 2001
    Publication date: September 5, 2002
    Inventors: Jacobus M. Lemmens, Theodorus H.A. Peters, Franciscus B.G. Benneker, Frantisek Picha
  • Process for making amlodipine maleate
    Publication number: 20020086888
    Abstract: A process for making amlodipine maleate comprises reacting amlodipine or an acid addition salt thereof with maleic acid under an acidic environment to form an amlodipine maleate product. The process allows for the formation of amlodipine maleate substantially free from amlodipine aspartate.
    Type: Application
    Filed: August 27, 2001
    Publication date: July 4, 2002
    Inventors: Franciscus B.G. Benneker, Pavel Slanina, Frantisek Picha