Patents by Inventor Franck Perez

Franck Perez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic single domain antibody
    Patent number: 10017559
    Abstract: The invention relates to the identification of a highly stable single domain antibody scaffold (hs2d Ab) and its use in generating synthetic single domain antibody library (hs2d Ab-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: July 10, 2018
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, INSTITUT CURIE, UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Aurellen Olichon, Sandrine Moutel, Franck Perez
  • Synthetic Single Domain Antibody
    Publication number: 20180030117
    Abstract: The invention relates to the identification of a highly stable single domain antibody scaffold (hs2d Ab) and its use in generating synthetic single domain antibody library (hs2d Ab-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.
    Type: Application
    Filed: June 30, 2017
    Publication date: February 1, 2018
    Inventors: Aurelien Olichon, Sandrine Moutel, Franck Perez
  • LENTIVIRAL VECTORS FOR REGULATED EXPRESSION OF A CHIMERIC ANTIGEN RECEPTOR MOLECULE
    Publication number: 20170166623
    Abstract: The invention relates to the regulated expression of a chimeric antigen receptor (CAR) within a lentiviral vector. The CAR comprises a hook-binding domain that interacts with a hook, preferably encoded by the same lentiviral vector, which prevents proper processing and release of the CAR to the cell membrane. The invention encompasses vectors, methods of making the vectors, and methods of using them, including medicinal uses. The vectors can be used for administration to humans to induce immune responses and to treat cancers and tumors.
    Type: Application
    Filed: July 24, 2015
    Publication date: June 15, 2017
    Inventors: Sophie AGAUGUE, Lorenzo TIBALDI, Klervi EVEN-DESRUMAUX, Dmitry TRUBETSKOY, Franck PEREZ, Sebastian AMIGORENA, Cécile BAUCHE
  • Synthetic Single Domain Antibody
    Publication number: 20160237142
    Abstract: The invention relates to the identification of a highly stable single domain antibody scaffold (hs2d Ab) and its use in generating synthetic single domain antibody library (hs2d Ab-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.
    Type: Application
    Filed: November 4, 2014
    Publication date: August 18, 2016
    Inventors: Aurellen Olichon, Sandrine Moutel, Franck Perez
  • METHODS AND KITS FOR REGULATING INTRACELLULAR TRAFFICKING OF A TARGET PROTEIN
    Publication number: 20120149101
    Abstract: A method and kits for regulating the intracellular trafficking of a target protein. In a retained state, the target protein is retained in a first compartment by an interaction with a hook protein. In a released state, the interaction is disrupted and the target protein traffics to a target compartment.
    Type: Application
    Filed: June 11, 2010
    Publication date: June 14, 2012
    Applicant: INSTITUT CURIE
    Inventor: Franck Perez
  • Antibody specific for the Tn antigen for the treatment of cancer
    Publication number: 20100278818
    Abstract: The instant application provides a pharmaceutical composition comprising an antibody, directed against Tn antigen which comprises CDRs derived from 83D4 monoclonal antibody or an immunoconjugate of said antibody, said pharmaceutical composition being intended for the treatment of cancer.
    Type: Application
    Filed: June 19, 2008
    Publication date: November 4, 2010
    Applicant: INSTITUT CURIE
    Inventors: Pascale Hubert-Haddad, Sebastian Amigorena, Xavier Sastre, Eduardo Osinaga, Otto Pritsch, Pablo Oppezzo, Franck Perez, Sandrine Moutel