Patents by Inventor Franck Slowinski

Franck Slowinski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8759343
    Abstract: The invention relates to compounds of the general formula (I): wherein R, m, n and o are as defined herein. The invention also relates to a method for preparing the same and to the application in therapy.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: June 24, 2014
    Assignee: Sanofi
    Inventors: Omar Ben Ayad, Odile LeClerc, Alistair Lochead, Mourad Saady, Franck Slowinski, Julien Vache
  • Publication number: 20120202807
    Abstract: The invention relates to compounds of the general formula (I): wherein R, m, n and o are as defined herein. The invention also relates to a method for preparing the same and to the application in therapy.
    Type: Application
    Filed: March 16, 2012
    Publication date: August 9, 2012
    Applicant: SANOFI
    Inventors: Omar Ben AYAD, Odile LECLERC, Alistair LOCHEAD, Mourad SAADY, Franck SLOWINSKI, Julien VACHE
  • Patent number: 8173669
    Abstract: The invention relates to compounds of the general formula (I): Wherein R, m, n and o are as defined herein. The invention also relates to a method for preparing the same and to the application in therapy.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: May 8, 2012
    Assignee: Sanofi-Aventis
    Inventors: Omar Ben Ayad, Odile Leclerc, Alistair Lochead, Mourad Saady, Franck Slowinski, Julien Vache
  • Patent number: 8148364
    Abstract: A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: Wherein Y, Z, R1, R2, R3, R4, R5, R6, R7, n, m, and o are as described herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3?, such as Alzheimer disease.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: April 3, 2012
    Assignees: Sanofi-Aventis, Mitsubishi Tanabe Pharma Corporation
    Inventors: Nathalie Chereze, Alistair Lochead, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • Patent number: 8093256
    Abstract: The invention relates to use of substituted-pyrimidone derivatives represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, R4, R5, n, p and q are as defined herein. More specifically, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of GSK3?, such as Pick's disease among various other diseases as claimed herein.
    Type: Grant
    Filed: June 18, 2007
    Date of Patent: January 10, 2012
    Assignees: Sanofi-Aventis, Mitsubishi Pharma Corporation
    Inventors: Alistair Lochead, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • Publication number: 20110294786
    Abstract: A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: Wherein Y, Z, R1, R2, R3, R4, R5, R6, R7, n, m, and o are as described herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3?, such as Alzheimer disease.
    Type: Application
    Filed: August 3, 2011
    Publication date: December 1, 2011
    Applicants: MITSUBISHI TANABE PHARMA CORPORATION, SANOFI-AVENTIS
    Inventors: Nathalie CHEREZE, Alistair LOCHEAD, Mourad SAADY, Franck SLOWINSKI, Philippe YAICHE
  • Patent number: 7781440
    Abstract: The invention relates to use of a pyrimidone derivative represented by formula (I) or a salt thereof as therapeutic agents: Wherein m, n, p, X, Y, R1, R2, R3, R4 R5, are as defined herein. The invention specifically relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3? or GSK3? and cdk5/p25, such as Alzheimer disease.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: August 24, 2010
    Assignees: Sanofi-Aventis, Mitsubishi Pharma Corporation
    Inventors: Thierry Gallet, Patrick Lardenois, Alistair Lochead, Severine Marguerie, Alain Nedelec, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • Publication number: 20100035916
    Abstract: The invention relates to compounds of the general formula (I): Wherein R, m, n and o are as defined herein. The invention also relates to a method for preparing the same and to the application in therapy.
    Type: Application
    Filed: August 4, 2009
    Publication date: February 11, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Omar BEN AYAD, Odile LECLERC, Alistair LOCHEAD, Mourad SAADY, Franck SLOWINSKI, Julien VACHE
  • Publication number: 20090281121
    Abstract: The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof: Wherein X, Y, R1, R2, R3, R4, n, p, q, o and m are as described herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3?, such as Alzheimer disease.
    Type: Application
    Filed: May 1, 2009
    Publication date: November 12, 2009
    Applicants: SANOFI-AVENTIS, MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Alistair LOCHEAD, Mourad SAADY, Franck SLOWINSKI, Philippe YAICHE
  • Patent number: 7547705
    Abstract: The invention relates to a dihydrospiro-[cycloalkylamine]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein: X, Y, R1, R2, R3, R4, o, m, n, p and q are as defined herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3?, such as Alzheimer disease.
    Type: Grant
    Filed: October 3, 2007
    Date of Patent: June 16, 2009
    Assignees: Sanofi-Aventis, Mitsubishi Pharma Corporation
    Inventors: Nathalie Chereze, Alistair Lochead, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • Patent number: 7507743
    Abstract: The invention relates to therapeutic uses of a dihydrospiro-[cycloalkyl]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, m, n, p and q are as described herein. Specifically, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3?, such as Alzheimer disease.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: March 24, 2009
    Assignees: Sanofi-Aventis, Mitsubishi Pharma Corporation
    Inventors: Pascal George, Alistair Lochead, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • Publication number: 20090036427
    Abstract: A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: Wherein Y, Z, R1, R2, R3, R4, R5, R6, R7, n, m, and o are as described herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3?, such as Alzheimer disease.
    Type: Application
    Filed: May 16, 2008
    Publication date: February 5, 2009
    Applicants: SANOFI-AVENTIS, MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Nathalie CHEREZE, Alistair LOCHEAD, Mourad SAADY, Franck SLOWINSKI, Philippe YAICHE
  • Patent number: 7462621
    Abstract: The invention relates to an use of pyrimidone derivative represented by formula (I) or a salt thereof: wherein m, n, p, X, Y, R1, R2, R3, R4 and R5 are as defined herein for treating a variety of disease states. More specifically, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3? or GSK3? and cdk5/p25, such as Alzheimer's disease.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: December 9, 2008
    Assignees: Sanofi-Aventis, Mitsubishi Pharma Corporation
    Inventors: Thierry Gallet, Patrick Lardenois, Alistair Lochead, Severine Marguerie, Alain Nedelec, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • Patent number: 7452897
    Abstract: The invention relates to therapeutic uses of a 2-(diaza-bicyclo-alkyl)-pyrimidone derivative represented by formula (I): Wherein R1, R2, R3, R4 and n are as defined herein. Specifically, the compounds of formula (I) are used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3?, such as Alzheimer's disease. The invention relates also to intermediates for the preparation of compound of formula (I).
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: November 18, 2008
    Assignees: Sanofi-Aventis, Mitsubishi Pharma Corporation
    Inventors: Alistair Lochead, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • Publication number: 20080269257
    Abstract: The invention relates to use of a pyrimidone derivative represented by formula (I) or a salt thereof as therapeutic agents: Wherein m, n, p, X, Y, R1, R2, R3, R4 R5, are as defined herein. The invention specifically relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3? or GSK3? and cdk5/p25, such as Alzheimer disease.
    Type: Application
    Filed: May 14, 2008
    Publication date: October 30, 2008
    Applicants: SANOFI-AVENTIS, MITSUBISHI PHARMA CORPORATION
    Inventors: Thierry Gallet, Patrick Lardenois, Alistair Lochead, Severine Marguerie, Alain Nedelec, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • Patent number: 7393853
    Abstract: The invention relates to use of a substituted-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, R4, R5, n, p and q are as described herein for treating a variety of disease states. More specifically, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of GSK3?, such as Pick's disease.
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: July 1, 2008
    Assignees: Sanofi Aventis, Mitsubishi Pharma Corp.
    Inventors: Alistair Lochead, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • Patent number: 7388005
    Abstract: The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof wherein: X represents two hydrogen atoms, a sulphur atom, an oxygen atom or a C1-2 alkyl group and a hydrogen atom; y represents a bond, an ethenylene group, an ethynylene group, an oxygen atom, a sulphur atom, a sulfonyl group, a sulfoxide group, a carbonyl group, a nitrogen atom being optionally; or a methylene group optionally substituted; R1 represents a pyrimidine group optionally substituted; R2 may represent a C1-6 alkyl group optionally substituted by a C6,10 aryloxy or a C6,10 arylamino group; a C3-6 cycloalkyl group, a C1-4 alkylthio group, a C1-4 alkoxy group, a C1-2 perhalogenated alkyl group, a C1-3 halogenated alkyl group, a phenylthio group, a benzyl group, a benzene ring, an indan ring, a 5,6,7,8-tetrahydronaphthalene ring, a naphthalene ring, a pyridine ring, a pyrrole ring, a thiophene ring, a furan ring or an imidazole ring; R3 and R4 represents each independently a hydrogen atom, C1-6 alkyl group,
    Type: Grant
    Filed: September 19, 2002
    Date of Patent: June 17, 2008
    Assignees: Sanofi-Aventis, Mitsubishi Pharma Corporation
    Inventors: Thierry Gallet, Patrick Lardenois, Alistair Lochead, Séverine Marguerie, Alain Nedelec, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • Publication number: 20080081819
    Abstract: The invention relates to therapeutic uses of a dihydrospiro-[cycloalkyl]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, m, n, p and q are as described herein. Specifically, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3?, such as Alzheimer disease.
    Type: Application
    Filed: October 2, 2007
    Publication date: April 3, 2008
    Applicants: SANOFI-AVENTIS, MITSUBISHI PHARMA CORPORATION
    Inventors: Pascal GEORGE, Alistair LOCHEAD, Mourad SAADY, Franck SLOWINSKI, Philippe YAICHE
  • Publication number: 20080081820
    Abstract: The invention relates to a dihydrospiro-[cycloalkylamine]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein: X represents two hydrogen atoms, a sulfur atom, an oxygen atom or a C1-2 alkyl group and a hydrogen atom; Y represents a bond, a carbonyl group, a methylene group optionally substituted; R1 represents a 2, 3 or 4-pyridine ring or a 2, 4 or 5-pyrimidine ring, the ring being optionally substituted; R2 represents a benzene ring or a naphthalene ring; the rings being optionally substituted; R3 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom; R4 represents a hydrogen atom, a C1-4 alkoxy carbonyl group, a C1-5 alkyl group optionally substituted; o and m represent 1 to 2; n represents 0 to 3; p represents 0 to 2; and q represents 0 to 2.
    Type: Application
    Filed: October 3, 2007
    Publication date: April 3, 2008
    Applicants: SANOFI-AVENTIS, MITSUBISHI PHARMA CORPORATION
    Inventors: Nathalie CHEREZE, Alistair Lochead, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • Publication number: 20080021046
    Abstract: The invention relates to use of substituted-pyrimidone derivatives represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, R4, R5, n, p and q are as defined herein. More specifically, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of GSK3?, such as Pick's disease among various other diseases as claimed herein.
    Type: Application
    Filed: June 18, 2007
    Publication date: January 24, 2008
    Applicants: SANOFI-AVENTIS, MITSUBISHI PHARMA CORPORATION
    Inventors: Alistair LOCHEAD, Mourad SAADY, Franck SLOWINSKI, Philippe YAICHE