Patents by Inventor Franco E Di Padova

Franco E Di Padova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODIES TO HUMAN IL-1BETA
    Publication number: 20110256151
    Abstract: An IL-1? binding molecule, in particular an antibody to human IL-1?, especially a human antibody to human IL-1? is provided, wherein the CDRs of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e.g. osteoarthritis, osteoporosis and other inflammatory arthritides.
    Type: Application
    Filed: June 29, 2011
    Publication date: October 20, 2011
    Inventors: HERMANN GRAM, FRANCO E. DI PADOVA
  • Methods of treating multiple myeloma using IL-17 binding molecules
    Patent number: 8012477
    Abstract: An IL-17 binding molecule, in particular an antibody to human IL-17, more preferably a human antibody to human IL-17 is provided, wherein the hypervariable regions of the heavy and light chains have amino acid sequences as defined, for use in the treatment of a solid or hematological malignant diseases.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: September 6, 2011
    Assignees: Novartis AG, Novartis Pharma GmbH
    Inventors: Michael Cooreman, Franco E. Di Padova
  • Antibodies to human IL-1?
    Patent number: 7993878
    Abstract: An IL-1? binding molecule, in particular an antibody to human IL-1?, especially a human antibody to human IL-1? is provided, wherein the CDRs of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e.g. osteoarthritis, osteoporosis and other inflammatory arthritides.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: August 9, 2011
    Assignee: Novartis AG
    Inventors: Hermann Gram, Franco E Di Padova
  • Methods of treating diabetes using IL-1beta antibodies
    Publication number: 20110182894
    Abstract: An IL-1? binding molecule, in particular an antibody to human IL-1?, especially a human antibody to human IL-1? is provided, wherein the CDRs of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e.g. osteoarthritis, osteoporosis and other inflammatory arthritides.
    Type: Application
    Filed: March 10, 2011
    Publication date: July 28, 2011
    Inventors: Hermann Gram, Franco E. Di Padova
  • IL-17 Antagonistic Antibodies
    Publication number: 20100266608
    Abstract: An IL-17 binding molecule, in particular an antibody to human IL-17, more preferably a human antibody to human IL-17 is provided, wherein the hypervariable regions of the heavy and light chains have amino acid sequences as defined, for use in the treatment of a solid or hematological malignant diseases.
    Type: Application
    Filed: January 30, 2007
    Publication date: October 21, 2010
    Inventors: Michael Cooreman, Franco E. Di Padova
  • IL-17 antagonistic antibodies
    Patent number: 7807155
    Abstract: An IL-17 binding molecule, in particular an antibody to human IL-17, more preferably a human antibody to human IL-17 is provided, wherein the hypervariable regions of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-17 mediated disease or disorder, e.g. rheumatoid arthritis.
    Type: Grant
    Filed: August 4, 2005
    Date of Patent: October 5, 2010
    Assignee: Novartis AG
    Inventors: Franco E. Di Padova, Hermann Gram, Hans Hofstetter, Margit Jeschke, Jean-Michel Rondeau, Wim Van Den Berg
  • IL-17 ANTAGONISTIC ANTIBODIES
    Publication number: 20100215666
    Abstract: An IL-17 binding molecule, in particular an antibody to human IL-17, more preferably a human antibody to human IL-17 is provided, wherein the hypervariable regions of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-17 mediated disease or disorder, e.g. rheumatoid arthritis.
    Type: Application
    Filed: February 18, 2010
    Publication date: August 26, 2010
    Inventors: FRANCO E. DI PADOVA, HERMANN GRAM, HANS HOFSTETTER, MARGIT JESCHKE, JEAN-MICHEL RONDEAU, WIM VAN DEN BERG
  • IL-17 Antagonistic Antibodies
    Publication number: 20090280131
    Abstract: An IL-17 binding molecule, in particular an antibody to human IL-17, more preferably a human antibody to human IL-17 is provided, wherein the hypervariable regions of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-17 mediated disease or disorder, e.g. rheumatoid arthritis.
    Type: Application
    Filed: August 4, 2005
    Publication date: November 12, 2009
    Inventors: Franco E. Di Padova, Hermann Gram, Hans Hofstetter, Margit Jeschke, Jean-Michel Rondeau, Wim Van Den Berg
  • ANTIBODIES TO HUMAN IL-1BETA
    Publication number: 20090232803
    Abstract: An IL-1? binding molecule, in particular an antibody to human IL-1?, especially a human antibody to human IL-1? is provided, wherein the CDRs of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e.g. osteoarthritis, osteoporosis and other inflammatory arthritides.
    Type: Application
    Filed: January 9, 2009
    Publication date: September 17, 2009
    Inventors: Hermann Gram, Franco E. Di Padova
  • ANTIBODIES TO HUMAN IL-1BETA
    Publication number: 20090081732
    Abstract: An IL-1? binding molecule, in particular an antibody to human IL-1?, especially a human antibody to human IL-1? is provided, wherein the CDRs of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e.g. osteoarthritis, osteoporosis and other inflammatory arthritides.
    Type: Application
    Filed: September 26, 2008
    Publication date: March 26, 2009
    Inventors: Hermann Gram, Franco E. Di Padova
  • Antibodies to human IL-1?
    Patent number: 7491392
    Abstract: An IL-1? binding molecule, in particular an antibody to human IL-1?, especially a human antibody to human IL-1? is provided, wherein the CDRs of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e.g. osteoarthritis, osteroporosis and other inflammatory arthritides.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: February 17, 2009
    Assignee: Novartis AG
    Inventors: Hermann Gram, Franco E Di Padova
  • Antibodies to human IL-1?
    Patent number: 7446175
    Abstract: An IL-1? binding molecule, in particular an antibody to human IL-1?, especially a human antibody to human IL-1? is provided, wherein the CDRs of the heavy and light chains having amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e.g. osteoarthritis, osteoporosis and other inflammatory arthritides.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: November 4, 2008
    Assignee: Novartis AG
    Inventors: Hermann Gram, Franco E. Di Padova
  • Human CD154 binding molecules and treatment methods
    Patent number: 7169389
    Abstract: A CD154 binding molecule, in particular an antibody to human CD154, especially a human antibody to human CD154 is provided, wherein the CDRs of the heavy chain and light chain have amino acid sequences as defined, for use in the treatment and/or prevention of diseases or disorders wherein CD154 modulation and/or interference with or inhibition of the CD154:CD40 interactions is therapeutically beneficial.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: January 30, 2007
    Assignee: Novartis AG
    Inventors: Franco E Di Padova, Walter Schuler
  • Antibodies to human il-1beta
    Publication number: 20040063913
    Abstract: An IL-1&bgr; binding molecule, in particular an antibody to human IL-1&bgr;, especially a human antibody to human IL-1&bgr; is provided, wherein the CDRs of the heavy and light chains having amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e.g. osteoarthritis, osteoporosis and other inflammatory arthritides.
    Type: Application
    Filed: October 15, 2003
    Publication date: April 1, 2004
    Inventors: Hermann Gram, Franco E. Di Padova
  • Antibodies to human mcp-1
    Publication number: 20040047860
    Abstract: MCP-1 binding molecules are provided comprising at least one immunoglobulin heavy chain variable domain (VH) comprising hypervariable regions CDR1, CDR2 and CDR3 of sequence as defined, for use in the treatment of MCP-1 or eotaxin-mediated diseases or disorders.
    Type: Application
    Filed: July 18, 2003
    Publication date: March 11, 2004
    Inventors: Peter Hiestand, Hans Hofstetter, Trevor Glyn Payne, Roman Urfer, Franco E Di Padova
  • Antibodies to human cd154
    Publication number: 20040038293
    Abstract: A CD154 binding molecule, in particular an antibody to human CD154, especially a human antibody to human CD154 is provided, wherein the CDRs of the heavy chain and light chain have amino acid sequences as defined, for use in the treatment and/or prevention of diseases or disorders wherein CD154 modulation and/or interference with or inhibition of the CD154:CD40 interactions is therapeutically beneficial.
    Type: Application
    Filed: September 13, 2002
    Publication date: February 26, 2004
    Inventors: Franco E. Di Padova, Walter Schuler
  • Antibodies to human il 1-beta
    Publication number: 20030124617
    Abstract: An IL-1&bgr; binding molecule, in particular an antibody to human IL-1&bgr;, especially a human antibody to human IL-1&bgr; is provided, wherein the CDRs of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e.g. osteoarthritis, osteroporosis and other inflammatory arthritides.
    Type: Application
    Filed: July 16, 2002
    Publication date: July 3, 2003
    Inventors: Hermann Gram, Franco E. Di Padova
  • Assays for measuring immunosuppressants by reporter gene expression
    Patent number: 5897990
    Abstract: Quantitative reporter gene assays allowing for highly precise measurements of immunosuppressants in bodily fluids are provided, e.g., an IL-2 reporter gene assay for measuring blood levels of immunosuppressive cyclosporins and ascomycins (e.g., cyclosporin A and FK-506), and a c-jun reporter gene assay for measuring blood levels of immunosuppressive rapamycins.
    Type: Grant
    Filed: September 17, 1996
    Date of Patent: April 27, 1999
    Assignee: Novartis AG
    Inventors: Goetz Baumann, Franco E. Di Padova, Peter Wenner