Patents by Inventor Franco J. Duarte

Franco J. Duarte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KAPPA OPIOID AGONISTS AND USES THEREOF
    Publication number: 20160145245
    Abstract: Provided are compounds of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds of Formula I described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.
    Type: Application
    Filed: June 27, 2014
    Publication date: May 26, 2016
    Inventors: Neel K. Anand, Franco J. Duarte, Wen Zhang, Zhongxu Ren
  • Oligomer-aryloxy-substituted propanamine conjugates
    Patent number: 9233165
    Abstract: The invention relates to (among other things) oligomer-aryloxy-substituted propanamine conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over un-conjugated aryloxy-substituted propanamine compounds.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: January 12, 2016
    Assignee: NEKTAR THERAPEUTICS
    Inventors: Jennifer Riggs-Sauthier, Franco J. Duarte
  • Oligomer-protease inhibitor conjugates
    Patent number: 9107956
    Abstract: The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the small molecule drug not attached to the water-soluble oligomer.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: August 18, 2015
    Assignee: NEKTAR THERAPEUTICS
    Inventors: Jennifer Riggs-Sauthier, Lin Cheng, Tacey X. Viegas, Xuyuan Gu, Franco J. Duarte, Wen Zhang
  • Reagents
    Patent number: 9095620
    Abstract: Oligomeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble, non-peptidic oligomer and a pharmaceutically active agent. The oligomeric reagents are useful for, among other things, forming oligomer active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: August 4, 2015
    Assignee: NEKTAR THERAPEUTICS
    Inventor: Franco J. Duarte
  • OLIGOMER-PROTEASE INHIBITOR CONJUGATES
    Publication number: 20140045770
    Abstract: The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the small molecule drug not attached to the water-soluble oligomer.
    Type: Application
    Filed: October 16, 2013
    Publication date: February 13, 2014
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Jennifer RIGGS-SAUTHIER, Lin Cheng, Tacey X. Viegas, Xuyuan Gu, Franco J. Duarte, Wen Zhang
  • Oligomer-protease inhibitor conjugates
    Patent number: 8598364
    Abstract: The invention provides protease inhibitors that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the protease inhibitors not attached to the water-soluble oligomer.
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: December 3, 2013
    Assignee: Nektar Therapeutics
    Inventors: Jennifer Riggs-Sauthier, Lin Cheng, Tacey X. Viegas, Xuyuan Gu, Franco J. Duarte, Wen Zhang
  • Oligomer-Protease Inhibitor Conjugates
    Publication number: 20110269677
    Abstract: The invention provides protease inhibitors that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the protease inhibitors not attached to the water-soluble oligomer.
    Type: Application
    Filed: March 12, 2008
    Publication date: November 3, 2011
    Applicant: Nektar Therapeutics
    Inventors: Jennifer Riggs-Sauthier, Lin Cheng, Tacey X. Viegas, Xuyuan Gu, Franco J. Duarte, Wen Zhang
  • Oligomer-Aryloxy-Substituted Propanamine Conjugates
    Publication number: 20110071207
    Abstract: The invention relates to (among other things) oligomer-aryloxy-substituted propanamine conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over un-conjugated aryloxy-substituted propanamine compounds.
    Type: Application
    Filed: April 13, 2009
    Publication date: March 24, 2011
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Jennifer Riggs-Sauthier, Franco J. Duarte
  • Novel Reagents
    Publication number: 20110071093
    Abstract: Oligomeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble, non-peptidic oligomer and a pharmaceutically active agent. The oligomeric reagents are useful for, among other things, forming oligomer active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.
    Type: Application
    Filed: March 12, 2009
    Publication date: March 24, 2011
    Applicant: Nektar Therapeutics
    Inventor: Franco J. Duarte
  • Oligomer-Beta Blocker Conjugates
    Publication number: 20100227865
    Abstract: The invention provides Beta-blocker drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a different biological membrane crossing rate as compared to the biological membrane crossing rate of the Beta-blocker drug not attached to the water soluble oligomer.
    Type: Application
    Filed: March 12, 2008
    Publication date: September 9, 2010
    Inventors: Jennifer Riggs-Sauthier, Franco J. Duarte, Aaron S. Hammons
  • De Novo Synthesis of Conjugates
    Publication number: 20100184989
    Abstract: The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.
    Type: Application
    Filed: March 12, 2008
    Publication date: July 22, 2010
    Applicant: Nektar Therapeutics
    Inventors: Jennifer Riggs-Sauthier, Bo-Liang Deng, Zhongxu Ren, Wen Zhang, Xuyuan Gu, Franco J. Duarte