Patents by Inventor Franco Manfre

Franco Manfre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11246823
    Abstract: The invention relates to the use of molecularly imprinted polymer(s) or MIPs, of odorous molecule(s), as deodorant agent in particular for selectively trapping molecules that are the cause of human body odour. More particularly by using MIPs which may be obtained via polymerization of “sol-gel” type; it being understood that the polymerization is performed in the presence v) of one or more “templates” of target molecule(s) responsible for human body odour. Another subject of the invention concerns a NI process for preparing MIPs as defined previously, MIPs obtained via this process, and a cosmetic composition comprising at least one MIP as defined previously. Unexpectedly, it appears that the MIPs make it possible to specifically trap precursors of odorous molecules and odorous molecules that may be used in cosmetic formulations, especially those that are the cause of the unpleasant odour of sweat.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: February 15, 2022
    Assignee: L'OREAL
    Inventors: Andrew Greaves, Franco Manfre, Karsten Haupt
  • Patent number: 10772822
    Abstract: The invention relates to a molecularly imprinted polymer obtained by polymerization of a mixture comprising a basic ethylene monomer having an amine group, a crosslinking agent comprising at least 2 polymerizable ethylene unsaturations, a porogenic solvent and a C14-C20 fatty acid. A cosmetic composition comprising such a polymer. A cosmetic process to prevent and/or treat dandruff of the scalp using such a polymer.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: September 15, 2020
    Assignee: L'OREAL
    Inventors: Andrew Greaves, Christèle Ribaud, Franco Manfre, Karsten Haupt
  • Patent number: 10772823
    Abstract: The invention relates to the use of molecularly imprinted polymer(s) or MIPs, of odorous molecule(s), as deodorant agent in particular for selectively trapping molecules that are the cause of human body odour. More particularly by using MIPs which may be obtained via polymerization, preferably via radical polymerization, of a mixture of: i) optionally one or more polymerization initiator(s); ii) one or more functional monomer(s); iii) one or more crosslinking agent(s); and iv) one or more porogenic solvent(s); it being understood that the polymerization a) or b) is performed in the presence v) of one or more “templates” of target molecule(s) responsible for human body odour. Another subject of the invention concerns a process for preparing MIPs as defined previously, MIPs obtained via this process, and a cosmetic composition comprising at least one MIP as defined previously.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: September 15, 2020
    Assignee: L'OREAL
    Inventors: Andrew Greaves, Franco Manfre, Karsten Haupt, Jeanne Bernadette Tse Sum Bui
  • Patent number: 8608808
    Abstract: A subject-matter of the invention is a composition comprising a) at least one ortho-diphenol derivative, b) at least one specific metal derivative and c) at least one basifying agent, a method for dyeing keratinous fibers by treatment of the said fibers using the ingredients a), b) et c) and the use thereof for dyeing keratinous fibers. This hair dyeing method makes it possible to obtain better colorations which are more uniform, chromatic and lasting and which do not detrimentally affect the cosmetic properties of the keratinous fibers, starting from an extract of ortho-diphenols which are in particular natural.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: December 17, 2013
    Assignee: L'Oreal
    Inventors: Christophe Rondot, Stéphane Sabelle, Alexandre Cavezza, Franco Manfre
  • Publication number: 20130139846
    Abstract: A subject-matter of the invention is a composition comprising a) at least one ortho-diphenol derivative, b) at least one specific metal derivative and c) at least one basifying agent, a method for dyeing keratinous fibres by treatment of the said fibres using the ingredients a), b) et c) and the use thereof for dyeing keratinous fibres. This hair dyeing method makes it possible to obtain better colorations which are more uniform, chromatic and lasting and which do not detrimentally affect the cosmetic properties of the keratinous fibres, starting from an extract of ortho-diphenols which are in particular natural.
    Type: Application
    Filed: December 21, 2010
    Publication date: June 6, 2013
    Applicant: L'OREAL
    Inventors: Christophe Rondot, Stéphane Sabelle, Alexandre Cavezza, Franco Manfre
  • Patent number: 7744657
    Abstract: The present disclosure relates to the dyeing of keratin materials using thiol/disulfide styryl tetrahydroquinolinium fluorescent dyes. Disclosed herein is a dye composition comprising a thiol/disulfide styryl tetrahydroquinolinium fluorescent dye and a dyeing process with, for instance, a lightening effect on keratin materials such as hair, using said composition. Disclosed herein are thiol fluorescent dyes and the uses thereof in lightening keratin materials. This composition can be used to obtain a lightening effect which can be resistant and visible on dark keratin fibers.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: June 29, 2010
    Assignee: L'Oreal S.A.
    Inventors: Andrew Greaves, Nicolas Daubresse, Franco Manfre
  • Patent number: 7717964
    Abstract: The disclosure relates to the dyeing of keratin materials using styryl hydroxy(cyclo)alkylamino thiol/disulfide fluorescent dyes. Disclosed herein is a dye composition comprising a styryl hydroxy(cyclo)alkylamino thiol/disulfide fluorescent dye and a dyeing process with, for example, a lightening effect on keratin materials such as hair, using said composition. Disclosed herein are novel thiol/disulfide fluorescent dyes and the uses thereof in lightening keratin materials. This composition makes it possible to obtain a lightening effect which can be resistant and visible on dark keratin fibers.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: May 18, 2010
    Assignee: L'Oreal S.A.
    Inventors: Nicolas Daubresse, Andrew Greaves, Franco Manfre
  • Publication number: 20060149051
    Abstract: The invention relates to a method of preparing an acylimidazolium-type reagent. More specifically, the invention relates to a salt of N-(benzyloxycarbonyl)-N?-methylimidazolium. The inventive method of preparing an acylimidazolium-type reagent is characterised in that it is obtained by: (i) reacting a reagent comprising a —COX group having formula (II) and an imidazole reagent having formula (III); and (ii) subsequently, adding a strong acid HY to the product thus obtained, said acid having a pKa of less than 1, which produces the desired reagent.
    Type: Application
    Filed: January 14, 2004
    Publication date: July 6, 2006
    Inventors: Thierry Schlama, Franco Manfre
  • Publication number: 20060100456
    Abstract: The invention relates to a process for the diastereoselective preparation of olefins via the Homer-Wadsworth-Emmons reaction, which consists in reacting at low temperature a phosphonate with a carbonyl derivative in the presence of a base in a suitable solvent, characterized in that a tris(polyoxaalkyl)amine sequestering reagent of formula (I): N—[CHR1—CHR2—O—(CHR3—CHR4—O)n—R5]3 (I), wherein: n is an integer between 0 and 10; R1, R2, R3 and R4 may be identical or different, and represent a hydrogen atom or an alkyl radical containing from 1 to 4 carbon atoms; R5 represents a hydrogen atom, an alkyl or cycloalkyl radical containing up to 12 carbon atoms, a phenyl radical or a radical of formula —C?H2?-?, or CmH2m+1-?-, with m being an integer between 1 and 12 and ? being a phenyl radical; is added in an amount that is sufficient to increase the diastereoselectivity of the olefin.
    Type: Application
    Filed: September 22, 2003
    Publication date: May 11, 2006
    Inventors: Fracois Touchard, Olivier Buisine, Frederic Leguyader, Thierry Schlama, Franco Manfre
  • Patent number: 6150387
    Abstract: This invention relates to the use of heterocyclic carboxamide compounds for preventing or reducing self-administration, by a human or animal patient, of a drug or a substance capable of giving rise to pharmacomania or to overuse. The preferred types of drugs or substances are nicotine, caffeine, benzodiazepines, narcotics, and hallucinogens.
    Type: Grant
    Filed: August 7, 1998
    Date of Patent: November 21, 2000
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Andrees Bohme, Marie-Christine Dubroeucq, Walter Fratta, Claude Guyon, Assunta Imperato, Franco Manfre
  • Patent number: 6127515
    Abstract: This invention is directed to a functionalized amino resin of formula ##STR1## wherein S is a solid support; R is H or alkyl; A is ##STR2## Y is OH or OCOR.sup.1 ; and R.sup.1 is aliphatic or aromatic which is useful for the solid phase synthesis of amides, peptides and hydroxamic acids.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: October 3, 2000
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Franco Manfre, Benoit J. Vanasse, Richard F. Labaudiniere, George C. Morton
  • Patent number: 6100264
    Abstract: A compound of the formula ##STR1## in which Ra represents an -alk-COOalk' radical, a --CH.sub.2 --PO(Oalk).sub.2 radical, a --CH.dbd.CH--COOalk' radical or a phenyl radical substituted with an alkoxycarbonyl radical.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: August 8, 2000
    Assignee: Rhone-Poulenc Rorer, S.A.
    Inventors: Jean-Claude Aloup, Jean Bouquerel, Dominique Damour, Jean-Claude Hardy, Patrick Jimonet, Franco Manfre, Serge Mignani, Patrick Nemecek
  • Patent number: 6057454
    Abstract: A compound of formula (II): ##STR1## in which R is a hydrogen atom or a carboxy, alkoxycarbonyl, --CO--NR.sub.4 R.sub.5, --PO.sub.3 H.sub.2 or --CH.sub.2 OH radical, and R.sub.1 is an -alk-NH.sub.2, -alk-NH--CO--R.sub.3, -alk-COOR.sub.4, -alk-CO--NR.sub.5 R.sub.6 or --CO--NH--R.sub.7 radical. The compounds of formula (II) can be used to prepare compounds of formula (I): ##STR2## in which R and R.sub.1 have the same meanings as above. The compounds of formula (I) have valuable pharmacological properties and are antagonists of the .alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, also known as the quisqualate receptor. The compounds of formula (I) are also non-competitive antagonists of the N-methyl-D-aspartate (NMDA) receptor and more specifically are ligands for NMDA receptor glycine modulator sites.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: May 2, 2000
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean-Claude Aloup, Fran.cedilla.ois Audiau, Michel Barreau, Dominique Damour, Arielle Genevois-Borella, Jean-Claude Hardy, Patrick Jimonet, Franco Manfre, Serge Mignani, Patrick Nemecek, Yves Ribeill
  • Patent number: 5990108
    Abstract: Compounds of formula (I), wherein R is a hydrogen atom or a --COOH, -alk-COOH, --PO.sub.3 H.sub.2, --CH.sub.2 --PO.sub.3 H.sub.2, or --CH.dbd.CH--COOH radical, or a phenyl radical substituted by a carboxy radical, R.sub.1 is an alk-CN, -alk-COOH, -alk-Het, alk-PO.sub.3 H.sub.2 or -alk-CO--NH--SO.sub.2 R.sub.2 radical, R.sub.2 is an alkyl or phenyl radical, alk is an alkyl radical, Het is a saturated or unsaturated mono- or polycyclic heterocyclic ring containing 1-9 carbon atoms and one or more heteroatoms selected from O, S and N, said heterocyclic ring optionally being substituted by one or more alkyl, phenyl or phenylalkyl radicals, with the proviso that when R is a hydrogen atom or a --COOH or --PO.sub.3 H.sub.2 radical, R.sub.1 cannot be -alk-COOH, isomers, racemic mixtures, enantiomers and diastereoisomers thereof, salts thereof, the preparation thereof, intermediates thereof and drugs containing said compounds, are disclosed.
    Type: Grant
    Filed: July 9, 1998
    Date of Patent: November 23, 1999
    Assignee: Rhone Poulenc Rorer S.A.
    Inventors: Jean-Claude Aloup, Jean Bouquerel, Dominique Damour, Jean-Claude Hardy, Patrick Jimonet, Franco Manfre, Serge Mignani, Patrick Nemecek
  • Patent number: 5902803
    Abstract: Compounds of formula (I), wherein R is a hydrogen atom or a carboxy, alkoxycarbonyl, --CO--NR.sub.4 R.sub.5, --PO.sub.3 H.sub.2 or --CH.sub.2 OH radical, and R.sub.1 is an -alk-NH.sub.2, -alk-NH--CO--R.sub.3, -alk-COOR.sub.4, -alk-CO--NR.sub.5 R.sub.6 or --CO--NH--R.sub.7 radical. The compounds of formula (I) have valuable pharmacological properties and are antagonists of the .alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor also known as the quisqualate receptor. Furthermore, the compounds of formula (I) are non-competitive antagonists of the N-methyl-D-aspartame (NMDA) receptor and more specifically are ligands for NMDA receptor glycine modulator sites.
    Type: Grant
    Filed: October 3, 1997
    Date of Patent: May 11, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean-Claude Aloup, Fran.cedilla.ois Audiau, Michel Barreau, Dominique Damour, Arielle Genevois-Borella, Jean-Claude Hardy, Patrick Jimonet, Franco Manfre, Serge Mignani, Patrick Nemecek, Yves Ribeill
  • Patent number: 5719317
    Abstract: A method for preparing a compound of formula (I), wherein R.sub.1 and R.sub.2, which are the same or different, are a hydrogen atom or an alkyl or alkoxy radical, or R.sub.1 and R.sub.2, taken together with the carbon atom to which they are attached, form a cycloalkyl radical containing 3-6 carbon atoms. The method comprises dehalogenating a derivative of formula (lI), wherein R.sub.1 and R.sub.2 have the same meanings as in formula (1) and Hal is a chlorine or bromine atom, using 1-2 mol of triethylammonium formate, in the presence of 0.002-0.1 mol of coal-borne palladium per mol of the compound of formula (II), in aceonitrile or tetrahydrofuran and at a temperature between 50.degree. C. and the boiling point of the reaction medium.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: February 17, 1998
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventor: Franco Manfre
  • Patent number: 5707991
    Abstract: The present invention relates to derivatives of formula: ##STR1## to their salts, to their preparation and to the medicaments containing them.
    Type: Grant
    Filed: June 28, 1995
    Date of Patent: January 13, 1998
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Marc Capet, Marie-Christine Dubroeucq, Franco Manfre
  • Patent number: 5686622
    Abstract: Thiazolidine derivatives of formula (I), in which R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined in the specification. The invention also concerns the salts of these derivatives, the preparation thereof and drugs containing same.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: November 11, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Marc Capet, Marie-Christine Dubroeucq, Claude Guyon, Franco Manfre
  • Patent number: 5676831
    Abstract: The present invention relates to a new isoindolinone derivative of formula: ##STR1## in racemic form or in the form of its enantiomers, as well as its salts, its preparation and the pharmaceutical compositions which contain it.
    Type: Grant
    Filed: September 11, 1996
    Date of Patent: October 14, 1997
    Assignee: Rhone-Poulec Rorer S.A.
    Inventors: Michel Barreau, Michel Cheve, Marie-Christine Dubroeucq, Gilles Dutruc-Rosset, Franco Manfre
  • Patent number: 5637602
    Abstract: This invention relates to a compound of formula (I), their salts, the preparation thereof and drugs containing same. The compounds of formula (I) have interesting pharmacological properties. Said compounds have a high affinity for chloecystokinin (CCK) and gastrin receptors and are therefore useful in the treatment and prevention of CCK and gastrin-related disorders affecting the nervous system and gastrointestinal tract.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 10, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Marc Capet, Marie-Christine Dubroeucq, Franco Manfre, Jean-Paul Martin