Patents by Inventor Franco Massaccesi

Franco Massaccesi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing a ketosulfone derivative
    Patent number: 9085532
    Abstract: The present invention relates to a process for preparing a ketosulfone derivative and, more particularly, to an improved method for synthesizing 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]ethanone by means of Pd-catalized alpha arylation process of a heteroaromatic ketone derivative.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: July 21, 2015
    Assignee: ZACH SYSTEM S.P.A.
    Inventors: Elisa Melotto, Ivan Michieletto, Vincenzo Frega, Livius Cotarca, Massimo Verzini, Franco Massaccesi, Ilaria Munari
  • The Process For Preparing a Ketosulfone Derivative
    Publication number: 20150133671
    Abstract: The present invention relates to a process for preparing a ketosulfone derivative and, more particularly, to an improved method for synthesising 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]ethanone by means of Pd-catalysed alpha arylation process of a heteroaromatic ketone derivative.
    Type: Application
    Filed: March 8, 2013
    Publication date: May 14, 2015
    Inventors: Elisa Melotto, Ivan Michieletto, Vincenzo Frega, Livius Cotarca, Massimo Verzini, Franco Massaccesi, Ilaria Munari
  • Process for preparing nebivolol
    Patent number: 8258323
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: September 4, 2012
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto, Franco Massaccesi
  • Process for preparing nebivolol
    Patent number: 8084629
    Abstract: The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a diastereoisomerically pure compound of RS/SR configuration characterized in that said reduction is carried out by the use of (+)-B-chlorodiisopinocampheylborane or (?)-B-chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: December 27, 2011
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Franco Massaccesi, Ilaria Munari, Livius Cotarca, Johnny Foletto
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20110201831
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Application
    Filed: April 29, 2011
    Publication date: August 18, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Raffaella VOLPICELLI, Paolo MARAGNI, Livius COTARCA, Johnny FOLETTO, Franco MASSACCESI
  • Process for preparing nebivolol
    Patent number: 7999124
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Grant
    Filed: November 23, 2007
    Date of Patent: August 16, 2011
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto, Franco Massaccesi
  • Crystalline forms of macrolide compounds endowed with antiinflammatory activity
    Patent number: 7956042
    Abstract: The present invention relates to macrolide compounds endowed with antiinflammatory activity and more particularly relates to new stable crystalline forms of a macrolide derivative with antiinflammatory activity, processes for the preparation of such forms, pharmaceutical compositions containing them as active ingredient and the use of said crystalline forms for the treatment of inflammatory diseases.
    Type: Grant
    Filed: July 5, 2006
    Date of Patent: June 7, 2011
    Assignee: Zambon S.p.A.
    Inventors: Paolo Maragni, Dario Braga, Roberto Brescello, Livius Cotarca, Alessandro Di Maria, Franco Massaccesi, Elisa Melotto, Ivan Michieletto, Gabriele Morazzoni, Mauro Napoletano, Franco Pellacini, Angelo Restelli, Massimo Verzini
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20110021793
    Abstract: The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a di-astereoisomerically pure compound of RS/SR configuration characterized in that said reduction is carried out by the use of (+)-B-chlorodiisopinocampheylborane or (?)-B-chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol.
    Type: Application
    Filed: March 16, 2009
    Publication date: January 27, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Franco Massaccesi, Ilaria Munari, Livius Cotarca, Johnny Foletto
  • PROCESS FOR THE PREPARATION OF LEVETIRACETAM
    Publication number: 20100076204
    Abstract: The present invention relates to a process for the preparation of levetiracetam and, more particularly, to an improved process for the preparation of levetiracetam characterized by a crystallization-induced dynamic resolution of a diastereoisomeric mixture of an (±)-alpha-ethyl-2-oxo-1-pyrrolidine acetamide derivative.
    Type: Application
    Filed: July 20, 2007
    Publication date: March 25, 2010
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Massimiliano FORCATO, Ivan MICHIELETTO, Paolo MARAGNI, Franco MASSACCESI, Livius COTARCA
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20100056813
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Application
    Filed: November 23, 2007
    Publication date: March 4, 2010
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto, Franco Massaccesi
  • CRYSTALLINE FORMS OF MACROLIDE COMPOUNDS ENDOWED WITH ANTIINFLAMMATORY ACTIVITY
    Publication number: 20090018089
    Abstract: the present invention relates to macrolide compounds endowed with antiinflammatory activity and more particularly relates to new stable crystalline forms of a macrolide derivative with antiinflammatory activity, processes for the preparation of such forms, pharmaceutical compositions containing them as active ingredient and the use of said crystalline forms for the treatment of inflammatory diseases.
    Type: Application
    Filed: July 5, 2006
    Publication date: January 15, 2009
    Applicant: ZAMBON S.p.A.
    Inventors: Paolo Maragni, Dario Braga, Roberto Brescello, Livius Cotarca, Alessandro Di Maria, Franco Massaccesi, Elisa Melotto, Ivan Michieletto, Gabriele Morazzoni, Mauro Napoletano, Franco Pellacini, Angelo Restelli, Massimo Verzini