Patents by Inventor Franco Ottoni

Franco Ottoni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Partricin derivatives
    Patent number: 5298495
    Abstract: Derivatives of partricin and of its individual components, partricin A and B, wherein the mycosamine primary amino group forms an amide bond with the carboxy group of acids containing in addition a basic nitrogen group, the carboxy group at C-18 of macrolide ring being either free or in form of ester or neutral amide or containing in the chain a basic nitrogen moiety, their pharmaceutically acceptable salts, a process for preparing the same and pharmaceutical formulations containing the same.
    Type: Grant
    Filed: December 3, 1991
    Date of Patent: March 29, 1994
    Assignee: SPA Societa' Prodotti Antibiotici SpA
    Inventors: Tiberio Bruzzese, Massino Signorini, Franco Ottoni
  • Amide derivatives of Partricin A & Partricin B
    Patent number: 5296597
    Abstract: The present invention is directed towards a series of secondary and tertiary amide derivatives of Partricin A & Partricin B attached at the C-18 carboxyl group. The compounds can be used in the treatment of hypercholesteremia and hyperlipemia conditions, of steroidal imbalances, and as antifungal and antiprotozoan agents.
    Type: Grant
    Filed: November 14, 1990
    Date of Patent: March 22, 1994
    Assignee: SPA Societa' Prodotti Antibiotici S.P.A.
    Inventors: Tiberio Bruzzese, Franco Ottoni, Giuseppe Ghielmetti
  • Pantothenyl derivatives
    Patent number: 4721728
    Abstract: Compounds of the following general structure (I) ##STR1## where R.sub.1 stands for an acyl radical of the following structure (II) ##STR2## where p1 X.sup.- is a halogen atom and R.sub.4 is a C.sub.1 -C.sub.4 acyl radical or a hydrogen atomR.sub.2 stands for an R.sub.1 radical as defined above or for a hydrogen atomR.sub.3 stands for a substituted hydroxymethyl CH.sub.2 OR.sub.1 group, where R.sub.1 has the same value as defined above, or for a carboxyl group.
    Type: Grant
    Filed: October 7, 1986
    Date of Patent: January 26, 1988
    Assignee: SpA Societa' Prodotti Antibiotici S.p.A.
    Inventors: Tiberio Bruzzese, Franco Ottoni, Holger H. Van Den Heuvel
  • Process for preparing 2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives and intermediates therefor
    Patent number: 4599406
    Abstract: The process for the preparation of derivatives of 2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide of the formula ##STR1## wherein R represents hydroxy (Ia) or substituted hydroxy OR.sub.1 in which R.sub.1 is the cinnamoyl radical --CO--CH.dbd.CH--C.sub.6 H.sub.5 (Ib) consists in reacting a strong base salt of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with an acyl chloride R.sub.1 Cl, in which R.sub.1 is the cinnamoyl radical, or R.sub.2 Cl, in which R.sub.2 is an aromatic or aliphatic C.sub.2 -C.sub.6 acyl radical to give the corresponding mixed anhydride, optionally esterified at position 4, which is then reacted with 2-aminopyridine to give the desired amide.
    Type: Grant
    Filed: December 13, 1984
    Date of Patent: July 8, 1986
    Assignee: SPA-Societa Prodotti Antibiotici spa
    Inventors: Tiberio Bruzzese, Ernani Dell'Acqua, Franco Ottoni, Holger H. van den Heuvel