Patents by Inventor Francois Bellamy
Francois Bellamy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10543223Abstract: The present invention relates to mannose derivatives of formula (I): wherein R1 represents H, CO—(C1-C6)-alkyl or CO-alkylaryl, Y represents a single bond, CH2, O, NR3, S, A represents O, NH or S, X represents H and X? represents OH or X and X? taken together with the carbon atom bearing them form a CO group, R2 represents H, a linear or branched (C1-C6)-alkyl or CF3, R3 represents H, a C1-C6 alkyl, a CO—(C1-C6)-alkyl, CF3 or COCF3, and R is as described in claim 1.Type: GrantFiled: August 5, 2016Date of Patent: January 28, 2020Assignees: ENTEROME, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLERMONT AUVERGNE, UNIVERSITE DE NANTESInventors: Sebastien Gouin, Thibault Chalopin, Julie Bouckaert, Nicolas Barnich, Adeline Sivignon, Dimitri Alexander Alvarez-Dorta, Francois Bellamy
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Publication number: 20180235991Abstract: The present invention relates to mannose derivatives of formula (I): wherein R1 represents H, CO—(C1-C6)-alkyl or CO-alkylaryl, Y represents a single bond, CH2, O, NR3, S, A represents O, NH or S, X represents H and X? represents OH or X and X? taken together with the carbon atom bearing them form a CO group, R2 represents H, a linear or branched (C1-C6)-alkyl or CF3, R3 represents H, a C1-C6 alkyl, a CO—(C1-C6)-alkyl, CF3 or COCF3, and R is as described in claim 1.Type: ApplicationFiled: August 5, 2016Publication date: August 23, 2018Inventors: Sebastien GOUIN, Thibault CHALOPIN, Julie BOUCKAERT, Nicolas BARNICH, Adeline SIVIGNON, Dimitri Alexander ALVAREZ-DORTA, Francois BELLAMY
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Patent number: 8940894Abstract: The present invention relates to an industrial process of preparing pharmaceutical compounds having the formula I: which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit and bcr-abl inhibitors. The groups R1 and R2, identical or different, represent each a hydrogen, halogen atom, an alkyl, an alkoxy, a trifluoromethyl, an amino, an alkylamino, a dialkylamino, a solubilising group; m is 0-5 and n is 0-4; the group R3 represents an aryl or an heteroaryl group as described in claims herein.Type: GrantFiled: May 10, 2013Date of Patent: January 27, 2015Assignee: AB ScienceInventors: Alain Moussy, Philippe Reginault, Francois Bellamy, Anne Lermet
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Patent number: 8492545Abstract: The present invention relates to an industrial process of preparing pharmaceutical compounds having the formula I: which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit and bcr-abl inhibitors. The groups R1 and R2, identical or different, represent each a hydrogen, halogen atom, an alkyl, an alkoxy, a trifluoromethyl, an amino, an alkylamino, a dialkylamino, a solubilising group; m is 0-5 and n is 0-4; the group R3 represents an aryl or an heteroaryl group as described in claims herein.Type: GrantFiled: March 8, 2012Date of Patent: July 23, 2013Assignee: AB ScienceInventors: Alain Moussy, Philippe Reginault, Francois Bellamy, Anne Lermet
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Publication number: 20120196871Abstract: The present invention relates to an industrial process of preparing pharmaceutical compounds having the formula I: which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit and bcr-abl inhibitors. The groups R1 and R2, identical or different, represent each a hydrogen, halogen atom, an alkyl, an alkoxy, a trifluoromethyl, an amino, an alkylamino, a dialkylamino, a solubilising group; m is 0-5 and n is 0-4; the group R3 represents an aryl or an heteroaryl group as described in claims herein.Type: ApplicationFiled: March 8, 2012Publication date: August 2, 2012Applicant: AB SCIENCEInventors: Alain MOUSSY, Philippe REGINAULT, François BELLAMY, Anne LERMET
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Patent number: 8153792Abstract: The present invention relates to an industrial process of preparing pharmaceutical compounds having the formula (1) which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit and bcr-abl inhibitors. The groups R1 and R2, identical or different, represent each a hydrogen, halogen atom, an alkyl, an alkoxy, a trifluoromethyl, an amino, an alkylamino, a dialkylamino, a solubilising group; m is 0-5 and n is 0-4; the group R3 represents an aryl or an heteroaryl group as described in claims herein.Type: GrantFiled: February 13, 2008Date of Patent: April 10, 2012Assignee: AB ScienceInventors: Alain Moussy, Philippe Reginault, François Bellamy, Anne Lermet
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Publication number: 20100121063Abstract: The present invention relates to an industrial process of preparing pharmaceutical compounds having the formula (1) which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit and bcr-abl inhibitors. The groups R1 and R2, identical or different, represent each a hydrogen, halogen atom, an alkyl, an alkoxy, a trifluoromethyl, an amino, an alkylamino, a dialkylamino, a solubilising group; m is 0-5 and n is 0-4; the group R3 represents an aryl or an heteroaryl group as described in claims herein.Type: ApplicationFiled: February 13, 2008Publication date: May 13, 2010Applicant: AB SCIENCEInventors: Alain Moussy, Philippe Reginault, Francois Bellamy, Anne Lermet
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Patent number: 7470671Abstract: The invention relates to novel 5-thioxylose compounds, preferably derivatives of the 5-thioxylopyranose type, to the method for their preparation and to their use as active principles of drugs intended especially for the treatment or prevention of thromboses or cardiac insufficiency.Type: GrantFiled: September 24, 2004Date of Patent: December 30, 2008Assignee: Laboratoire FournierInventors: Véronique Barberousse, Soth Samreth, Benaïssa Boubia, François Bellamy, Vincent Peyrou
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Publication number: 20070054955Abstract: The invention relates to novel 5-thioxylose compounds, preferably derivatives of the 5-thioxylopyranose type, to the method for their preparation and to their use as active principles of drugs intended especially for the treatment or prevention of thromboses or cardiac insufficiency.Type: ApplicationFiled: September 24, 2004Publication date: March 8, 2007Applicant: Laboratoires Fournier S.A.Inventors: Veronique Barberousse, Soth Samreth, Benaissa Boubia, Francois Bellamy, Vincent Peyrou
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Patent number: 5451609Abstract: This invention is concerned with a novel anti-impotence composition and a novel method for the treatment of impotence, whereby deacetyl moxisylyte or one of its non-toxic salts is administered in a ready to use aqueous solution by injection per intracavernosal route, as a drug inducing a substantially rigid penile erection.Type: GrantFiled: July 27, 1994Date of Patent: September 19, 1995Assignee: Institut De Recherches Chimiques et alInventors: Francois Bellamy, Philippe Reginault, Bernard Rasquin
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Patent number: 5246961Abstract: The present invention relates, by way of novel industrial products, to the .beta.-D-phenylthioxyloside compounds of the formula ##STR1## in which: X represents a sulfur atom or an oxygen atom;R.sub.1, R.sub.2 and R.sub.3, which are identical or different, each represent a hydrogen atom, a nitro group, a cyano group, a group --CO--R (in which R represents a C.sub.1 -C.sub.4 alkyl group or a trifluoromethyl group), an amino group, an acetamido group (NHCOCH.sub.3), a C.sub.1 -C.sub.4 alkoxy group, a trifluoromethyl group or a phenyl group substituted by one or more cyano, nitro or trifluoromethyl groups, it being possible for R.sub.1 and R.sub.2, taken together, to form, with the phenyl group to which they are bonded, a .beta.-naphthalenyl group which is unsubstituted or substituted by one or more cyano, nitro or trifluoromethyl groups; andY represents the hydrogen atom or an aliphatic acyl group.Type: GrantFiled: November 18, 1991Date of Patent: September 21, 1993Assignee: Fournier Industrie et SanteInventors: Soth Samreth, Jean Millet, Francois Bellamy
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Patent number: 5169838Abstract: The present invention relates, by way of novel industrial products which are useful in therapy, to the benzopyranone-.beta.-D-thioxyloside compounds of the formula ##STR1## in which: one of the substituents R or R' is an oxygen atom double-bonded to the corresponding cyclic carbon atom and the other is a group R.sub.1,the symbol represents a double bond conjugated to the CO group provided by one of the substituents R or R',X is a sulfur atom or an oxygen atom,R.sub.1 and R.sub.2, which are identical or different, are each a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, a halogen atom, a trifluoromethyl group or a phenyl group, it being possible for R.sub.1 and R.sub.2, taken together, to form a 7,8,9,10-tetrahydrodibenzo[b,d]pyran-6-one group or a 1,2,3,4-tetrahydro-9H-xanthen-9-one group with the benzopyranone group to which they are bonded, andY is the hydrogen atom or an aliphatic acyl group.Type: GrantFiled: September 10, 1990Date of Patent: December 8, 1992Assignee: Fournier Industrie et SanteInventors: Soth Samreth, Veronique Barberousse, Patrice Renaut, Francois Bellamy, Jean Millet
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Patent number: 5101048Abstract: The present invention relates, by way of novel industrial products, to the .beta.-D-phenylthioxyloside compounds of the formula ##STR1## in which: X represents a sulfur atom or an oxygen atom;R.sub.1, R.sub.2 and R.sub.3, which are identical or different, each represent a hydrogen atom, a nitro group, a cyano group, a group --CO--R (in which R represents a C.sub.1 -C.sub.4 alkyl group or a trifluoromethyl group), an amino group, an acetamido group (NHCOCH.sub.3), a C.sub.1 -C.sub.4 alkoxy group, a trifluoromethyl group or a phenyl group substituted by one or more cyano, nitro or trifluoromethyl groups, it being possible for R.sub.1 and R.sub.2, taken together, to form, with the phenyl group to which they are bonded, a .beta.-naphthalenyl group which is unsubstituted or substituted by one or more cyano, nitro or trifluoromethyl groups; andY represents the hydrogen atom or an aliphatic acyl group.These compounds are useful as therapeutic agents, especially as venous antithrombotics.Type: GrantFiled: October 18, 1989Date of Patent: March 31, 1992Assignee: Fournier Industrie et SanteInventors: Jerzy Bajgrowicz, Patrice Renaut, Veronique Barberousse, Soth Samreth, Jean Millet, Francois Bellamy
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Patent number: 4996347Abstract: The present invention relates, by way of novel industrial products, to osides selected from the group consisting of:(i) the .beta.-.eta.-phenylthioxylosides of the formula: ##STR1## in which: R represents a hydrogen atom, a halogen atom, a nitro group or a cyano group,A represents the sulfur atom or the oxygen atom,B represents a CH.sub.2, CHOH or CO group andY represents the hydrogen atom or an acyl group; and(ii) epimers thereof when B is CHOH.These products are useful in therapy as antithrombotics.Type: GrantFiled: June 27, 1989Date of Patent: February 26, 1991Assignee: Fournier Innovation et SynergieInventors: Soth Samreth, Francois Bellamy, Jean Millet
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Patent number: 4960758Abstract: The present invention relates to .beta.-D-phenylthioxyloside compounds selected from the group consisting of:(i) the .beta.-D-phenylthioxylosides of the formula: ##STR1## in which: R.sub.1 and R.sub.2, which can be identical or different, which represent a hydrogen atom or a trifluoromethy or cyano group,A represents CHOH or CO andY represents a hydrogen atom or an acyl group; and(ii) epimers thereof when A is CHOH.The said .beta.-D-phenylthioxyloside compounds are useful in therapy as antithrombotics.Type: GrantFiled: November 3, 1988Date of Patent: October 2, 1990Assignee: Fournier Innovation et SynergieInventors: Soth Samreth, Francois Bellamy, Jean Millet
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Patent number: 4900833Abstract: The present invention relates to novel asymmetrical esters derived from 1,4-dihydropyridine-3,5-dicarboxylic acid, of the formula: ##STR1## in which: R.sub.1 represents a C.sub.1 -C.sub.4 alkyl group, R.sub.2 represents a C.sub.1 -C.sub.4 alkyl group, a benzyl group, a benzoyl group or a phenyl group optionally substituted by one or more C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkyl, cyano, nitro, hydroxyl or trifluoromethyl groups or by one or more halogen atoms, and R.sub.3 and R.sub.4, which are identical or different, each represent the hydrogen atom, a nitro group or a chlorine atom,their optical isomers and diastereoisomers and also the corresponding addition salts.These novel esters are useful in therapy, especially as antihypertensives.Type: GrantFiled: September 22, 1988Date of Patent: February 13, 1990Assignee: Societe de Recherches Industries (S.O.R.I.)Inventors: Jacques Robin, Didier Pruneau, Francois Bellamy
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Patent number: 4877808Abstract: The present invention relates, by way of novel industrial products, to osides selected from the group consisting of:(i) the .beta.-D-phenylthioxylosides of the formula: ##STR1## in which: R represents a hydrogen atom, a halogen atom, a nitro group or a cyano group,A represents the sulfur atom or the oxygen atom,B represents a CH.sub.2, CHOH or CO group andY represents the hydrogen atom or an acyl group; and(ii) epimers thereof when B is CHOH.These products are useful in therapy as antithrombotics.Type: GrantFiled: April 25, 1988Date of Patent: October 31, 1989Assignee: Fournier Innovation et SynergieInventors: Soth Samreth, Francois Bellamy, Jean Millet
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Patent number: 4806544Abstract: The present invention relates to novel asymmetrical esters derived from 1,4-dihydrophyridine-3,5-dicarboxylic acid, of the formula: ##STR1## in which: R.sub.1 represents a C.sub.1 -C.sub.4 alkyl group, R.sub.2 represents a C.sub.1 -C.sub.4 alkyl group, a benzyl group, a benzoyl group or a phenyl group optionally substituted by one or more C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkyl, cyano, nitro, hydroxyl or trifluoromethyl groups or by one or more halogen atoms, and R.sub.3 and R.sub.4, which are identical or different, each represent the hydrogen atom, a nitro group or a chlorine atom, their optical isomers and diastereoisomers and also the corresponding addition salts.These novel esters are useful in therapy, especially as antihypertensives.Type: GrantFiled: March 18, 1987Date of Patent: February 21, 1989Assignee: Fournier Innovation et SynergieInventors: Jacques Robin, Didier Pruneau, Francois Bellamy
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Patent number: 4680402Abstract: Intermediate products usable in particular for preparing corresponding amino derivatives by converting their nitro function, said products being of formula: ##STR1## in which: R.sub.1, R.sub.2 and R.sub.3, which are identical or different, each represent an atom of hydrogen, a halogen, a lower alkyl group or a lower alkoxy group;R.sub.5 and R.sub.6, which are identical or different, each represent an atom of hydrogen, a lower alkyl group, an OH group, a phenyl group or a benzyl group.Type: GrantFiled: May 30, 1986Date of Patent: July 14, 1987Assignee: Societe de Recherches Industrielles (S.O.R.I.)Inventors: Bernard Majoie, Francois Bellamy, Pierre Dodey, Jacques Robin
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Patent number: 4598068Abstract: The present invention relates, by way of new industrial products, to the benzylphenyl osides of the formula ##STR1## in which: X.sub.1, X.sub.2, X.sub.3, X.sub.4 and X.sub.5, which are identical or different, each represent a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkyl group substituted by one or more halogen atoms (in particular a CF.sub.3 group), an OH group, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.1 -C.sub.4 alkoxy group substituted by one or more halogen atoms, a nitro group, a group NR'R" (in which R' and R", which are identical or different, each represent the hydrogen atom, a C.sub.1 -C.sub.4 alkyl group or an acetyl group), a methylthio group, a methylsulfinyl group or a mesyl group, andR represents an ose radical chosen from the group comprising(a) the .alpha.Type: GrantFiled: July 18, 1984Date of Patent: July 1, 1986Assignee: Societe de Recheres IndustriellesInventors: Soth Samreth, Francois Bellamy, Jean-Bernard Chazan