Abstract: Cholesterol and desmosterol levels, and the ratio of these levels can be used as a blood biomarker for Alzheimer's disease, frontotemporal lobar degeneration, or dementia with Lewy bodies.

Abstract: Desmosterol alone, the combination of desmosterol and amyloid beta, the combination of desmosterol and gelsolin and the combination of desmosterol, amyloid beta and gelsolin can be used as in-blood biomarkers for Alzheimer's disease or mild cognitive impairment. A method for evaluating the effect of a candidate for a therapeutic agent to treat Alzheimer's disease or mild cognitive impairment, a method for aiding the diagnosis of Alzheimer's disease or mild cognitive impairment, and a method for diagnosing Alzheimer's disease or mild cognitive impairment are provided in which the biomarkers are used.

Abstract: Desmosterol alone, the combination of desmosterol and amyloid beta, the combination of desmosterol and gelsolin and the combination of desmosterol, amyloid beta and gelsolin can be used as in-blood biomarkers for Alzheimer's disease or mild cognitive impairment. A method for evaluating the effect of a candidate for a therapeutic agent to treat Alzheimer's disease or mild cognitive impairment, a method for aiding the diagnosis of Alzheimer's disease or mild cognitive impairment, and a method for diagnosing Alzheimer's disease or mild cognitive impairment are provided in which the biomarkers are used.

Abstract: The invention relates to a method of manufacturing locks for doors of a plurality of models of motor vehicles, each lock comprising a latch (1) which is rotatable about an axis (A) and which is associated with a pawl (2) rotatable about an axis (B), and also a mechanical and/or electrical transmission arrangement for carrying out an identical list of commands, the positioning of the fastening points (3, 4, 5) of these locks being identical, and the relative positioning of their “S point” (S1, S2) being different. According to the invention, said mechanical and/or electrical transmission arrangement of each of the locks is identical and only the assembly consisting of the latch and the associated pawl is different for each model of vehicles, in order to achieve said positioning of the “S point”.

Abstract: The present invention provides a pharmaceutical composition comprising at least one member selected from a compound capable of enhancing A?37 production, a compound capable of inhibiting A?40 and A?42 production and enhancing A?37 production, and salts of the compounds and hydrates thereof.