Abstract: The stoppering device comprises an internally threaded stopper and an externally threaded bottle neck, the bottle neck being provided with a flange situated axially between on the one hand the lower end of the thread of the neck and on the other hand the body of the bottle proper, the bottle neck comprising on this flange at least two radially outwardly projecting catches of which one constitutes an orientation stop and the other a lobe to prevent unscrewing. The stopper comprises at least one catch made of a slightly deformable substance which, after screwing down, becomes accommodated between the two catches of the bottle neck. The orientation stop and the lobe to prevent unscrewing have different shapes, and the orientation stop extends along a direction parallel to the axis of the bottle neck over an axial extent which is greater than that of the flange and the orientation stop projects in relation this flange on the opposite side from the thread.