Patents by Inventor Francois Collin

Francois Collin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190256923
    Abstract: The present invention relates to biomarkers associated with breast cancer prognosis. These biomarkers include coding transcripts and their expression products, as well as non-coding transcripts, and are useful for predicting the likelihood of breast cancer recurrence in a breast cancer patient. The present invention also relates to a novel method of identifying intergenic sequences that correlate with a clinical outcome.
    Type: Application
    Filed: January 17, 2019
    Publication date: August 22, 2019
    Applicant: GENOMIC HEALTH, INC.
    Inventors: Joffre B. BAKER, Dominick SINICROPI, Robert J. PELHAM, Michael R. CRAGER, Francois COLLIN, James C. STEPHANS, Mei-Lan LIU, John D. MORLAN, Kunbin QU
  • Publication number: 20190241967
    Abstract: The present invention provides methods to determine the prognosis and appropriate treatment for patients diagnosed with cancer, based on the expression levels of one or more biomarkers. More particularly, the invention relates to the identification of genes, or sets of genes, able to distinguish breast cancer patients with a good clinical prognosis from those with a bad clinical prognosis. The invention further provides methods for providing a personalized genomics report for a cancer patient. The inventions also relates to computer systems and software for data analysis using the prognostic and statistical methods disclosed herein.
    Type: Application
    Filed: January 9, 2019
    Publication date: August 8, 2019
    Applicant: GENOMIC HEALTH, INC.
    Inventors: Joffre B. BAKER, Maureen T. CRONIN, Francois COLLIN, Mei-Lan LIU
  • Publication number: 20180365283
    Abstract: A system is designed for processing instructions in real time during a session. This system comprises: a preloader for obtaining reference data relating to the instructions, the reference data indicating the current values of each specified resource account data file, and the preloader being arranged to read the reference data for a plurality of received instructions in parallel from a master database; an enriched instruction queue for queuing the instructions together with their respective preloaded reference data; an execution engine for determining sequentially whether each received instruction can be executed under the present values of the relevant resource account files and for each executable instruction to generate an updating command; and an updater, responsive to the updating command from the execution engine (for updating the master database with the results of each executable instruction, the operation of the plurality of updaters being decoupled from the operation of the execution engine.
    Type: Application
    Filed: June 19, 2018
    Publication date: December 20, 2018
    Applicant: Euroclear SA/NV
    Inventors: Henri Petit, Jean-Francois Collin, Nicolas Marechal, Christine Deloge
  • Patent number: 10025809
    Abstract: A system is designed for processing instructions in real time during a session. This system comprises: a preloader for obtaining reference data relating to the instructions, the reference data indicating the current values of each specified resource account data file, and the preloader being arranged to read the reference data for a plurality of received instructions in parallel from a master database; an enriched instruction queue for queuing the instructions together with their respective preloaded reference data; an execution engine for determining sequentially whether each received instruction can be executed under the present values of the relevant resource account files and for each executable instruction to generate an updating command; and an updater, responsive to the updating command from the execution engine (for updating the master database with the results of each executable instruction, the operation of the plurality of updaters being decoupled from the operation of the execution engine.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: July 17, 2018
    Assignee: Euroclear SA/NV
    Inventors: Henri Petit, Jean-Francois Collin, Nicolas Marechal, Christine Deloge
  • Publication number: 20170211154
    Abstract: The present invention provides methods to determine the prognosis and appropriate treatment for patients diagnosed with cancer, based on the expression levels of one or more biomarkers. More particularly, the invention relates to the identification of genes, or sets of genes, able to distinguish breast cancer patients with a good clinical prognosis from those with a bad clinical prognosis. The invention further provides methods for providing a personalized genomics report for a cancer patient. The inventions also relates to computer systems and software for data analysis using the prognostic and statistical methods disclosed herein.
    Type: Application
    Filed: February 3, 2017
    Publication date: July 27, 2017
    Applicant: GENOMIC HEALTH, INC.
    Inventors: Joffre B. BAKER, Maureen T. CRONIN, Francois COLLIN, Mei-Lan LIU
  • Publication number: 20160259881
    Abstract: The present invention provides methods for incorporating transcript chromosomal locus information for identification of biomarkers of disease recurrence risk.
    Type: Application
    Filed: October 28, 2014
    Publication date: September 8, 2016
    Inventors: Michael C. Kiefer, Francois Collin, Samuel Levy, Joffre B. Baker, Michael R. Crager, Mark R. Segal
  • Publication number: 20160222463
    Abstract: The present invention relates to biomarkers associated with breast cancer prognosis. These biomarkers include coding transcripts and their expression products, as well as non-coding transcripts, and are useful for predicting the likelihood of breast cancer recurrence in a breast cancer patient, The present invention also relates to a novel method of identifying intergenic sequences that correlate with a clinical outcome.
    Type: Application
    Filed: January 29, 2016
    Publication date: August 4, 2016
    Applicant: GENOMIC HEALTH, INC.
    Inventors: Joffre B. BAKER, Dominick S. SINICROPI, Robert J. PELHAM, Michael R. CRAGER, Francois COLLIN, James C. STEPHANS, Mei-Lan LIU, John D. MORLAN, Kunbin QU
  • Publication number: 20140296085
    Abstract: The present invention relates to biomarkers associated with breast cancer prognosis. These biomarkers include coding transcripts and their expression products, as well as non-coding transcripts, and are useful for predicting the likelihood of breast cancer recurrence in a breast cancer patient, The present invention also relates to a novel method of identifying intergenic sequences that correlate with a clinical outcome.
    Type: Application
    Filed: November 2, 2012
    Publication date: October 2, 2014
    Applicant: GENOMIC HEALTH, INC.
    Inventors: Joffre B. Baker, Dominick S. Sinicropi, Robert J. Pelham, Michael R. Crager, Francois Collin, James C. Stephans, Mei-Lan Liu, John D. Morlan, Kunbin Qu
  • Patent number: 8765383
    Abstract: The present disclosure provides methods for assessing a patient's cancer risk and/or recurrence risk, which methods comprise assaying, in a biological sample obtained from the gastrointestinal (GI) tract of the patient, an expression level of a risk gene. The present disclosure also provides methods involving a cancer risk/recurrence risk sequence, i.e. the V600E mutation of the BRAF gene, which is useful for assessing cancer risk and/or recurrence risk in a patient.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: July 1, 2014
    Assignee: Genomic Health, Inc.
    Inventors: Wayne Cowens, Maureen T. Cronin, Carl L. Millward, Francois Collin, Michael Crager
  • Publication number: 20140149342
    Abstract: A system is designed for processing instructions in real time during a session. This system comprises: a preloader for obtaining reference data relating to the instructions, the reference data indicating the current values of each specified resource account data file, and the preloader being arranged to read the reference data for a plurality of received instructions in parallel from a master database; an enriched instruction queue for queuing the instructions together with their respective preloaded reference data; an execution engine for determining sequentially whether each received instruction can be executed under the present values of the relevant resource account files and for each executable instruction to generate an updating command; and an updater, responsive to the updating command from the execution engine (for updating the master database with the results of each executable instruction, the operation of the plurality of updaters being decoupled from the operation of the execution engine.
    Type: Application
    Filed: November 20, 2013
    Publication date: May 29, 2014
    Applicant: EUROCLEAR SA/NV
    Inventors: Henri Petit, Jean-Francois Collin, Nicolas Marechal, Christine Deloge
  • Patent number: 8612299
    Abstract: A system is designed for processing instructions in real time during a session. This system comprises: a preloader for obtaining reference data relating to the instructions, the reference data indicating the current values of each specified resource account data file, and the preloader being arranged to read the reference data for a plurality of received instructions in parallel from a master database; an enriched instruction queue for queuing the instructions together with their respective preloaded reference data; an execution engine for determining sequentially whether each received instruction can be executed under the present values of the relevant resource account files and for each executable instruction to generate an updating command; and an updater, responsive to the updating command from the execution engine (for updating the master database with the results of each executable instruction, the operation of the plurality of updaters being decoupled from the operation of the execution engine.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: December 17, 2013
    Assignee: Euroclear SA/NV
    Inventors: Henri Petit, Jean-Francois Collin, Nicolas Marechal, Christine Deloge
  • Publication number: 20110123990
    Abstract: The present invention provides methods to determine the prognosis and appropriate treatment for patients diagnosed with cancer, based on the expression levels of one or more biomarkers. More particularly, the invention relates to the identification of genes, or sets of genes, able to distinguish breast cancer patients with a good clinical prognosis from those with a bad clinical prognosis. The invention further provides methods for providing a personalized genomics report for a cancer patient. The inventions also relates to computer systems and software for data analysis using the prognostic and statistical methods disclosed herein.
    Type: Application
    Filed: November 19, 2010
    Publication date: May 26, 2011
    Inventors: Joffre B. BAKER, Maureen T. Cronin, Francois Collin, Mei-Lan Liu
  • Publication number: 20110004788
    Abstract: A system is designed for processing instructions in real time during a session. This system comprises: a preloader for obtaining reference data relating to the instructions, the reference data indicating the current values of each specified resource account data file, and the preloader being arranged to read the reference data for a plurality of received instructions in parallel from a master database; an enriched instruction queue for queuing the instructions together with their respective preloaded reference data; an execution engine for determining sequentially whether each received instruction can be executed under the present values of the relevant resource account files and for each executable instruction to generate an updating command; and an updater, responsive to the updating command from the execution engine (for updating the master database with the results of each executable instruction, the operation of the plurality of updaters being decoupled from the operation of the execution engine.
    Type: Application
    Filed: February 27, 2009
    Publication date: January 6, 2011
    Applicant: EUROCLEAR SA/NV
    Inventors: Henri Petit, Jean-Francois Collin, Nicolas Marechal, Christine Deloge
  • Publication number: 20100291573
    Abstract: The present disclosure provides methods for assessing a patient's cancer risk and/or recurrence risk, which methods comprise assaying, in a biological sample obtained from the gastrointestinal (GI) tract of the patient, an expression level of a risk gene. The present disclosure also provides methods involving a cancer risk/recurrence risk sequence, i.e. the V600E mutation of the BRAF gene, which is useful for assessing cancer risk and/or recurrence risk in a patient.
    Type: Application
    Filed: April 6, 2010
    Publication date: November 18, 2010
    Inventors: Wayne Cowens, Maureen T. Cronin, Carl L. Millward, Francois Collin, Michael Crager
  • Patent number: 7020561
    Abstract: The present invention provides systems and methods for analyzing gene expression, gene annotation, and sample information in a relational format supporting efficient exploration and analysis, including comparative differential expression analysis, expression pattern matching, and mapping of external attributes or identifiers to internal representations of gene fragments or samples.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: March 28, 2006
    Assignee: Gene Logic, Inc.
    Inventors: Kevin McLoughlin, Francois Collin, Victor M. Markowitz, Thodoros Topaloglou, Alexandros Athanasopoulos