Patents by Inventor Francois Dalencon
Francois Dalencon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170326221Abstract: The invention relates to a method of detoxifying a lipopolysaccharide (LPS) or a lipid A from a Gram-negative bacterium, which comprises mixing the LPS or the lipid A with a cationic lipid so as to form a complex in which the LPS or the lipid A is associated with the cationic lipid. According to the conventional preparation modes, the cationic lipid with the co-lipid, if this latter is present, get(s) structured into complexes i.a. liposomes. When preparing lipidic complexes, the addition of LPS or Lipid A leads to an association of this latter with the cationic lipid and as a result, the LPS or lipid A is substantially detoxified. The LPS or lipid A detoxified by the complexes, e.g. when incorporated into liposomes, can be used as vaccinal antigen or as adjuvant.Type: ApplicationFiled: August 7, 2017Publication date: November 16, 2017Applicant: Sanofi Pasteur SAInventors: Jean Haensler, Francois Dalencon, Monique Moreau, Noelle Mistretta
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Publication number: 20160367655Abstract: The present invention provides compositions comprising a Chlamydial major outer membrane protein (referenced herein as “MOMP”), from at least one Chlamydial serovar and an adjuvant, characterized in that the adjuvant comprises the product E6020 having CAS Number 287180-63-6. The composition may further comprise at least one carrier system (e.g., emulsion, mineral particle). The MOMP protein may be derived from any species of Chlamydia (e.g., C. trachomatis, C. pneumoniae, C. psittaci, or C. trachomatis MoPn). In preferred embodiments, the composition comprises one or more major outer membrane proteins each derived from different serovars of C. trachomatis. The invention also provides methods of inducing an immune response to a Chlamydia species (e.g., C. trachomatis) in a subject, by administering to the subject a composition of the invention.Type: ApplicationFiled: March 21, 2016Publication date: December 22, 2016Inventors: Scott Gallichan, Ausra Mancevski, Nathalie Reveneau, Jin Su, Francois Dalencon, Jean Haensler
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Patent number: 9327021Abstract: The present invention provides compositions comprising a Chlamydial major outer membrane protein (referenced herein as “MOMP”), from at least one Chlamydial serovar and an adjuvant, characterized in that the adjuvant comprises the product E6020 having CAS Number 287180-63-6. The composition may further comprise at least one carrier system (e.g., emulsion, mineral particle). The MOMP protein may be derived from any species of Chlamydia (e.g., C. trachomatis, C. pneumoniae, C. psittaci, or C. trachomatis MoPn). In preferred embodiments, the composition comprises one or more major outer membrane proteins each derived from different serovars of C. trachomatis. The invention also provides methods of inducing an immune response to a Chlamydia species (e.g., C. trachomatis) in a subject, by administering to the subject a composition of the invention.Type: GrantFiled: November 15, 2011Date of Patent: May 3, 2016Assignees: Sanofi Pasteur Limited, Sanofi Pasteur S.A.Inventors: Scott Gallichan, Ausra Mancevski, Nathalie Reveneau, Jin Su, Francois Dalencon, Jean Haensler
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Publication number: 20140178478Abstract: The invention relates to an oil-in-water adjuvant emulsion which comprises at least: squalene, an aqueous solvent, a polyoxyethylene alkyl ether nonionic surfactant, a hydrophobic nonionic surfactant, which emulsion is thermoreversible, and wherein 90% of the population by volume of the oil drops has a size less than 200 nm. The invention also relates to a process for preparing an immunogenic composition according to which at least one vaccine antigen is mixed with an oil-in-water emulsion, wherein the oil-in-water emulsion is obtained by means of a temperature-variation phase-inversion process.Type: ApplicationFiled: February 28, 2014Publication date: June 26, 2014Applicant: Sanofi PasteurInventors: Marie-Francoise Klucker, Francois Dalencon, Patricia Probeck-Quellec
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Patent number: 8703095Abstract: The invention relates to an oil-in-water adjuvant emulsion which comprises at least: squalene, an aqueous solvent, a polyoxyethylene alkyl ether nonionic surfactant, a hydrophobic nonionic surfactant, which emulsion is thermoreversible, and wherein 90% of the population by volume of the oil drops has a size less than 200 nm. The invention also relates to a process for preparing an immunogenic composition according to which at least one vaccine antigen is mixed with an oil-in-water emulsion, wherein the oil-in-water emulsion is obtained by means of a temperature-variation phase-inversion process.Type: GrantFiled: July 7, 2006Date of Patent: April 22, 2014Assignee: Sanofi Pasteur S.A.Inventors: Marie-Francoise Klucker, Francois Dalencon, Patricia Probeck-Quellec
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Publication number: 20130344109Abstract: The present invention provides compositions comprising a Chlamydial major outer membrane protein (referenced herein as “MOMP”), from at least one Chlamydial serovar and an adjuvant, characterized in that the adjuvant comprises the product E6020 having CAS Number 287180-63-6. The composition may further comprise at least one carrier system (e.g., emulsion, mineral particle). The MOMP protein may be derived from any species of Chlamydia (e.g., C. trachomatis, C. pneumoniae, C. psittaci, or C. trachomatis MoPn). In preferred embodiments, the composition comprises one or more major outer membrane proteins each derived from different serovars of C. trachomatis. The invention also provides methods of inducing an immune response to a Chlamydia species (e.g., C. trachomatis) in a subject, by administering to the subject a composition of the invention.Type: ApplicationFiled: November 15, 2011Publication date: December 26, 2013Applicants: SANOFI PASTEUR, S.A., SANOFI PASTEUR LIMITEDInventors: Scott Gallichan, Ausra Mancevski, Nathalie Reveneau, Jin Su, Francois Dalencon, Jean Haensler
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Publication number: 20100291192Abstract: The invention relates to a method of detoxifying a lipopolysaccharide (LPS) or a lipid A from a Gram-negative bacterium, which comprises mixing the LPS or the lipid A with a cationic lipid so as to form a complex in which the LPS or the lipid A is associated with the cationic lipid. According to the conventional preparation modes, the cationic lipid with the co-lipid, if this latter is present, get(s) structured into complexes i.a. liposomes. When preparing lipidic complexes, the addition of LPS or Lipid A leads to an association of this latter with the cationic lipid and as a result, the LPS or lipid A is substantially detoxified. The LPS or lipid A detoxified by the complexes, e.g. when incorporated into liposomes, can be used as vaccinal antigen or as adjuvant.Type: ApplicationFiled: May 14, 2010Publication date: November 18, 2010Applicant: Sanofi PasteurInventors: Jean Haensler, François Dalençon, Monique Moreau, Noëlle Mistretta
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Publication number: 20070014805Abstract: The invention relates to an oil-in-water adjuvant emulsion which comprises at least: squalene, an aqueous solvent, a polyoxyethylene alkyl ether nonionic surfactant, a hydrophobic nonionic surfactant, which emulsion is thermoreversible, and wherein 90% of the population by volume of the oil drops has a size less than 200 nm. The invention also relates to a process for preparing an immunogenic composition according to which at least one vaccine antigen is mixed with an oil-in-water emulsion, wherein the oil-in-water emulsion is obtained by means of a temperature-variation phase-inversion process.Type: ApplicationFiled: July 7, 2006Publication date: January 18, 2007Applicant: Sanofi PasteurInventors: Francois Dalencon, Marie-Francoise Klucker, Patricia Probeck-Quellec
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Publication number: 20060165717Abstract: The present invention involves the use of DCchol for preparing a vaccine composition intended to be administered to newborns.Type: ApplicationFiled: January 24, 2006Publication date: July 27, 2006Inventors: Francois Dalencon, Claire-Anne Siegrist