Patents by Inventor Francois Desgrandchamps

Francois Desgrandchamps has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HLA-G transcripts and isoforms and their uses
    Patent number: 11655283
    Abstract: Embodiments of the disclosure pertain to the field of HLA-G molecules and their therapeutic use. The disclosure pertains to new HLA-G isoforms, that is to say new RNA transcripts and proteins deriving from the HLA-G gene, pharmaceutical composition comprising thereof, as well as primers specific of these transcripts and antibodies specific of these proteins. The disclosure further pertains to the diagnostic or therapeutic use of these molecules.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: May 23, 2023
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: Edgardo D. Carosella, Diana Tronik-Le Roux, Jean-Philippe Deslys, Jérôme Verine, François Desgrandchamps, Nathalie Rouas-Freiss, Joël Le Maoult
  • METHODS FOR THE MONITORING AND PROGNOSIS OF A CANCER
    Publication number: 20200158715
    Abstract: The present invention relates to methods for prognosis and monitoring of a cancer, preferably bladder cancer, by measuring the proportion of CD8+ T Lymphocytes expressing ILT-2 and the plasma level of soluble HLA-G. The invention also relates to anti HLA-G antibodies for use for treating a cancer in which tumor cells express HLA-G, preferably bladder cancer.
    Type: Application
    Filed: January 28, 2020
    Publication date: May 21, 2020
    Inventors: François Desgrandchamps, Edgardo Delfino Carosella, Joël Lemaoult
  • HLA-G TRANSCRIPTS AND ISOFORMS AND THEIR USES
    Publication number: 20200148743
    Abstract: Embodiments of the disclosure pertain to the field of HLA-G molecules and their therapeutic use. The disclosure pertains to new HLA-G isoforms, that is to say new RNA transcripts and proteins deriving from the HLA-G gene, pharmaceutical composition comprising thereof, as well as primers specific of these transcripts and antibodies specific of these proteins. The disclosure further pertains to the diagnostic or therapeutic use of these molecules.
    Type: Application
    Filed: July 24, 2018
    Publication date: May 14, 2020
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
    Inventors: Edgardo D. Carosella, Diana Tronik-Le Roux, Jean-Philippe Deslys, Jérôme Verine, François Desgrandchamps, Nathalie Rouas-Freiss, Joël Le Maoult
  • Methods for the monitoring and prognosis of a cancer
    Patent number: 10545136
    Abstract: The present invention relates to methods for prognosis and monitoring of a cancer, preferably bladder cancer, by measuring the proportion of CD8+ T Lymphocytes expressing ILT-2 and the plasma level of soluble HLA-G. The invention also relates to anti HLA-G antibodies for use for treating a cancer in which tumor cells express HLA-G, preferably bladder cancer.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: January 28, 2020
    Assignees: ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, Université Paris Diderot—Paris 7
    Inventors: François Desgrandchamps, Edgardo Delfino Carosella, Joël Lemaoult
  • METHODS FOR THE MONITORING AND PROGNOSIS OF A CANCER
    Publication number: 20170219561
    Abstract: The present invention relates to methods for prognosis and monitoring of a cancer, preferably bladder cancer, by measuring the proportion of CD8+ T Lymphocytes expressing ILT-2 and the plasma level of soluble HLA-G. The invention also relates to anti HLA-G antibodies for use for treating a cancer in which tumor cells express HLA-G, preferably bladder cancer.
    Type: Application
    Filed: October 16, 2015
    Publication date: August 3, 2017
    Inventors: François Desgrandchamps, Edgardo Delfino Carosella, Joël Lemaoult
  • Artificial implant intended to replace the human urinary and excretory organs
    Patent number: 6296668
    Abstract: The object of the invention is an implant not requiring major surgery for its insertion or for the partial replacement of any of its elements; said prosthesis can be applied for long-term placement. The implant disclosed replaces the entire urinary organs, thereby precluding any possible anastomosis, said implant comprising a double-layered (7, 8) structure for the artificial replacing elements: tubular elements (1, 3) for the renal ducts and urethra, a reservoir (2) for the bladder, and an artificial urethral sphincter (4). The aritificial tubular elements of renal ducts (1) are connected to the reservoir (2) by mechanical attachments (5), said elements (1 to 3) being constituted and formed so that they can pass from a flattened state when empty to an expanded state.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: October 2, 2001
    Assignee: Assistance Publique-Hopitaux de Paris
    Inventors: Francois Desgrandchamps, Alain Le Duc
  • Method to refrigerate a jacket for keeping a transplant cold
    Patent number: 5701746
    Abstract: A jacket (10) for keeping a transplant (46) cold during the time the transplant in surgical way is connected to a receiver comprises a wall (12, 14) with a cavity (22) containing a frozen liquid, which melts under absorption of heat from the transplant. Before the transplant is placed in the jacket (10), the liquid, e.g. water, is frozen by being subjected to vacuum, vapour released from the liquid being absorbed by a substance, e.g. zeolite.
    Type: Grant
    Filed: July 25, 1996
    Date of Patent: December 30, 1997
    Assignee: Electrolux S.A.R.L.
    Inventors: Francois Desgrandchamps, Michel Eugene, Nico Girrens, Fernand Muller, Sylvia Spaniol