Abstract: The present disclosure provides mTOR agonists that selectively modulate proteasome dynamics, compositions, methods and uses thereof for modulation of stress-induced proteasome dynamics and related pathological conditions. The present disclosure specifically provides therapeutic methods for treating disorders associated with cytosolic accumulation of the proteasome. The invention further provides prognostic methods for detection and monitoring drug resistant cancers, as well as methods for screening for modulators of proteasome dynamics.

Abstract: A direct injection, solenoid fuel injector includes at least one current sensing function capable of detecting a current draw of the solenoid and a controller function. The controller is capable of determining a fully open time of the direct fuel injector solenoid based on the application of a slope inflection filter and a slope discrimination filter to a derivative of the current draw.

Abstract: The present invention concerns the use of a furfural derivative of formula (I) in which R represents (i) a —CH?CR?1—COR1 group, a group a group a group or a —CHO and R? represents a hydrogen atom or a (C1-C4)alkyl group, as a chemical vehicle, as a solvent, co-solvent, coalescing agent, crystallization inhibitor, plasticising agent, degreasing agent, etchant, cleaning agent or agent for increasing biological activity, and more particularly as a solvent. It also concerns phytosanitary formulations or resin-solubilising formulations comprising at least one such furfural derivative of formula (I).

Abstract: A power supply diagnostic circuit includes a switching power supply that generates a voltage for powering a fuel injector. An injector control module selectively applies the voltage to the fuel injector and monitors a resultant electrical current flow through the fuel injector. The switching power supply includes a dual path circuit comprising two inductors, two MOSFETs, and two diodes. The injector control module determines whether one path of the dual path circuit is defective based on the electrical current flow.

Abstract: A direct injection, solenoid fuel injector includes at least one current sensing function capable of detecting a current draw of the solenoid and a controller function. The controller is capable of determining a fully open time of the direct fuel injector solenoid based on the application of a slope inflection filter and a slope discrimination filter to a derivative of the current draw.

Abstract: A power supply diagnostic circuit includes a switching power supply that generates a voltage for powering a fuel injector. An injector control module selectively applies the voltage to the fuel injector and monitors a resultant electrical current flow through the fuel injector. The switching power supply includes a dual path circuit comprising two inductors, two MOSFETs, and two diodes. The injector control module determines whether one path of the dual path circuit is defective based on the electrical current flow.