Patents by Inventor Francois Fay

Francois Fay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETING THE INNATE IMMUNE SYSTEM TO INDUCE LONG-TERM TOLERANCE AND TO RESOLVE MACROPHAGE ACCUMULATION IN ATHEROSCLEROSIS
    Publication number: 20230218537
    Abstract: Methods and compositions for inducing long-term tolerance by hybrid nanoparticles are provided. Compositions and formulations comprising hybrid nanoparticles with inherent affinity for innate immune cells are provided.
    Type: Application
    Filed: March 14, 2023
    Publication date: July 13, 2023
    Inventors: Willem Mulder, Jordi Ochando, Zahi Fayad, Mounia Braza, Raphaël Duivenvoorden, Francois Fay
  • Mass production and size control of nanoparticles through controlled microvortices
    Patent number: 10864162
    Abstract: Methods for making particles, such as nanoparticles, devices useful in the methods, and particles made by the method are described herein. The methods involves the use of microfluidic device, such that upon mixing solutions of the materials to form the particles (or a solution of the material or materials to form the particles and a non-solvent for the material or materials) at least two symmetrical microvortices are formed simultaneously. The method can be used to prepare polymeric or non-polymeric particles and hybrid particles, such as lipid-polymer hybrid particles, as well as such particles containing one or more agents associated with the particles.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: December 15, 2020
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC., ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: YongTae Kim, Zahi Fayad, Willem J. Mulder, Edward Fisher, Francois Fay, Omid C. Farokhzad, Robert Langer
  • TARGETING THE INNATE IMMUNE SYSTEM TO INDUCE LONG-TERM TOLERANCE AND TO RESOLVE MACROPHAGE ACCUMULATION IN ATHEROSCLEROSIS
    Publication number: 20190290593
    Abstract: Methods and compositions for inducing long-term tolerance by hybrid nanoparticles are provided. Compositions and formulations comprising hybrid nanoparticles with inherent affinity for innate immune cells are provided.
    Type: Application
    Filed: May 1, 2017
    Publication date: September 26, 2019
    Applicant: Icahn School of Medicine at Mount Sinai
    Inventors: Willem MULDER, Jordi OCHANDO, Zahi FAYAD, Mounia BRAZA, Raphael DUIVENVOORDEN, Francois FAY
  • MASS PRODUCTION AND SIZE CONTROL OF NANOPARTICLES THROUGH CONTROLLED MICROVORTICES
    Publication number: 20170333348
    Abstract: Methods for making particles, such as nanoparticles, devices useful in the methods, and particles made by the method are described herein. The methods involves the use of microfluidic device, such that upon mixing solutions of the materials to form the particles (or a solution of the material or materials to form the particles and a non-solvent for the material or materials) at least two symmetrical microvortices are formed simultaneously. The method can be used to prepare polymeric or non-polymeric particles and hybrid particles, such as lipid-polymer hybrid particles, as well as such particles containing one or more agents associated with the particles.
    Type: Application
    Filed: June 8, 2017
    Publication date: November 23, 2017
    Inventors: Yong Tae Kim, Zahi Fayad, Willem J. Mulder, Edward Fisher, Francois Fay, Omid C. Farokhzad, Robert Langer
  • Modulator
    Patent number: 8962032
    Abstract: There is provided a method for suppressing a pro-inflammatory immune response in a cell, comprising providing to a cell sialic acid or analogs thereof, wherein the sialic acid or analogs are presented by a substrate such that a pro-inflammatory immune response in a cell is suppressed or an anti-inflammatory immune response is increased in a cell. Further, there is provided a method of treatment of inflammatory disease in a subject in need thereof. There is also provided a drug delivery device and a biomaterial which can modulate the inflammatory response in a subject.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: February 24, 2015
    Assignee: The Queen's University of Belfast
    Inventors: Christopher Scott, James Johnston, Shaun Spence, Danny McAuley, Francois Fay
  • MODULATOR
    Publication number: 20120294946
    Abstract: There is provided a method for suppressing a pro-inflammatory immune response in a cell, comprising providing to a cell sialic acid or analogs thereof, wherein the sialic acid or analogs are presented by a substrate such that a pro-inflammatory immune response in a cell is suppressed or an anti-inflammatory immune response is increased in a cell. Further, there is provided a method of treatment of inflammatory disease in a subject in need thereof. There is also provided a drug delivery device and a biomaterial which can modulate the inflammatory response in a subject.
    Type: Application
    Filed: December 17, 2010
    Publication date: November 22, 2012
    Inventors: Christopher Scott, James Johnston, Shaun Spence, Danny McAuley, Francois Fay