Patents by Inventor Francois Lacoste
Francois Lacoste has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11969734Abstract: A three-dimensional grinder includes: a stationary grinding chamber having a generally cylindrical wall along a longitudinal axis XX and delimiting an inner space, the chamber receiving and mixing a starting compound, and generally at least two, in a liquid medium, forming an initial mixture, the stationary grinding chamber being partially filled with a grinding body, which stationary grinding chamber includes, at a first end, an inlet introducing the starting compound and the liquid medium and, at a second end, an outlet discharging an end product formed in the stationary grinding chamber; a stirrer in the stationary grinding chamber, including a rod extending along the longitudinal axis XX, the stirrer being capable of pivoting to move the grinding body/initial mixture mass, the stationary grinding chamber including, in the inner space, a heating device to heat an area of the stationary grinding chamber. The heating device is an introduction heating device.Type: GrantFiled: May 27, 2019Date of Patent: April 30, 2024Assignee: DEASYL SAInventors: Julien Thiel, François Lacoste, Valentin Lair, Samy Halloumi, Irène Malpartida, Benoît Moevus
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Patent number: 11872413Abstract: The present invention relates to a method for controlling a probe for the treatment of brain tissue using an assembly comprising the probe and an acoustic window (1), the probe (2) including a plurality of transducers (21) for generating ultrasound waves, the method comprising: —a phase of detection: •of the probe transducers situated above the cranium (4) of the patient, and •of the probe transducers situated above the acoustic window (1), so as to permit: •deactivation of the transducers situated above the cranium (4) of the patient, •activation of the transducers situated above the acoustic window (1).Type: GrantFiled: June 19, 2018Date of Patent: January 16, 2024Assignees: ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, SORBONNE UNIVERSITE, CARTHERAInventors: Alexandre Carpentier, Guillaume Bouchoux, Michael Canney, Francois Lacoste
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Publication number: 20230242500Abstract: A method for manufacturing solketal ((2,2-Dimethyl-1,3-dioxolan-4-yl)methanol) includes: (1) milling starting reagents, including at least: glycerol, a catalyst selected from a hard Lewis acid including at least one transition metal, and acetone, the molar ratio (glycerol):(acetone) being less than or equal to 0.8; preferably less than or equal to 0.7, at an ambient temperature greater than or equal to 50° C., preferably greater than or equal to 56° C., in a three-dimensional microbead mill in a liquid phase for a residence time less than or equal to 15 minutes, preferably less than or equal to 10 minutes, and in particular less than or equal to 5 minutes; (2) recovering, as output from the mill, a final composition including solketal and, where appropriate, one or more sub-products corresponding to the starting reagents that have not reacted and/or to 1,3-O-isopropylidene-glycerol, and (3) optionally, separating the solketal from the one or more sub-products.Type: ApplicationFiled: December 1, 2020Publication date: August 3, 2023Inventors: Christophe LEN, Mohamad KHODADADI, Julien THIEL, François LACOSTE
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Publication number: 20220149356Abstract: Disclosed is an electrode for a rechargeable energy storage device, including several inner layers interposed between two outer layers, the inner layers including several electrode material layers ME composed of at least one electrode active material and several porous current collector layers CC composed of electrically-conductive material(s) whose electronic conductivity is greater than or equal to 102 S·cm-1, the layers of electrode material ME and current collector CC being alternated. The outer layers do not consist of the porous current collector layers CC. Additionally, the electrode has a total thickness ranging from strictly more than 4 mm, preferably ranging from strictly more than 4 mm to 10 mm, in particular ranging from strictly more than 4 mm to 8 mm.Type: ApplicationFiled: February 27, 2020Publication date: May 12, 2022Inventors: Vincent CALDEIRA, Julien THIEL, Marian CHATENET, Laëtitia DUBAU, François LACOSTE
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Patent number: 11235979Abstract: Disclosed is a method for manufacturing crystals of aluminates of one or more element(s) other than aluminium, referred to as “A. The method includes: placing starting reagents, including at least one aluminium element source and a source of the element(s) A that has a degree of oxidation of between 1 and 6, in suspension in a liquid medium, forming a suspension referred to as the “starting suspension”; milling the starting suspension at ?50° C., in a three-dimensional liquid medium ball mill for ?5 minutes; recovering, at the outlet of the three-dimensional ball mill, a suspension referred to as the “end suspension” including the starting reagents in activated form or crystals of aluminate of the element(s) A generally in hydrated form; if required, calcination of the end suspension when it includes the starting reagents in activated form, to obtain generally non-hydrated crystals of aluminate of the element(s) A.Type: GrantFiled: October 5, 2017Date of Patent: February 1, 2022Assignee: EASYLInventors: François Lacoste, Valentin Lair, Julien Thiel, Samy Halloumi
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Publication number: 20220001213Abstract: A device for treatment of a tissue (8) of a living being, including a transducer (4) for emitting a beam of ultrasound waves mounted on a movable treatment head (1), an ultrasonic imaging device (2, 3), optionally an inflatable balloon (5) surrounding the treatment head (1) and containing a coupling fluid, and a control unit for controlling movement of the treatment head (1) and operation of the transducer (4) and the imaging device (2, 3). In order to avoid displacement of tissues (7, 8) during displacement of the treatment head (1) and increase imaging quality, the treatment head (1) is adjustable to at least two of a treatment position (T), a monitoring position (M) and a travel position (S).Type: ApplicationFiled: September 15, 2021Publication date: January 6, 2022Inventors: Francois LACOSTE, Thierry PECHOUX
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Patent number: 11135455Abstract: The present invention relates to an ultrasonic probe for heating, internally, an ultrasonically absorbent target medium, the probe comprising: at least one piezoelectric transducer (21) having a front face (212) intended to be positioned facing the target medium and a back face (211) opposite the front face (212), the transducer being able to emit at least one primary wave emanating from its front face and at least one secondary wave emanating from its back face, the probe being noteworthy in that it furthermore comprises: a reflector (24) facing the back face (211) of the transducer (21), the reflector (24) being suitable for reflecting the secondary wave emitted by the transducer (21); and a cooling-fluid layer (25) between the transducer (21) and the reflector (24).Type: GrantFiled: April 14, 2017Date of Patent: October 5, 2021Assignee: CARTHERAInventors: Michael Canney, Guillaume Bouchoux, Alexandre Vignot, Francois Lacoste
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Patent number: 11123576Abstract: A device for treatment of a tissue (8) of a living being, including a transducer (4) for emitting a beam of ultrasound waves mounted on a movable treatment head (1), an ultrasonic imaging device (2, 3), optionally an inflatable balloon (5) surrounding the treatment head (1) and containing a coupling fluid, and a control unit for controlling movement of the treatment head (1) and operation of the transducer (4) and the imaging device (2, 3). In order to avoid displacement of tissues (7, 8) during displacement of the treatment head (1) and increase imaging quality, the treatment head (1) is adjustable to at least two of a treatment position (T), a monitoring position (M) and a travel position (S).Type: GrantFiled: December 11, 2014Date of Patent: September 21, 2021Assignee: THERACLION SAInventors: Francois Lacoste, Thierry Pechoux
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Publication number: 20210213459Abstract: A three-dimensional grinder includes: a stationary grinding chamber having a generally cylindrical wall along a longitudinal axis XX and delimiting an inner space, the chamber receiving and mixing a starting compound, and generally at least two, in a liquid medium, forming an initial mixture, the stationary grinding chamber being partially filled with a grinding body, which stationary grinding chamber includes, at a first end, an inlet introducing the starting compound and the liquid medium and, at a second end, an outlet discharging an end product formed in the stationary grinding chamber; a stirrer in the stationary grinding chamber, including a rod extending along the longitudinal axis XX, the stirrer being capable of pivoting to move the grinding body/initial mixture mass, the stationary grinding chamber including, in the inner space, a heating device to heat an area of the stationary grinding chamber. The heating device is an introduction heating device.Type: ApplicationFiled: May 27, 2019Publication date: July 15, 2021Inventors: Julien THIEL, François LACOSTE, Valentin LAIR, Samy HALLOUMI, Irène MALPARTIDA, Benoît MOEVUS
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Patent number: 10941094Abstract: A method for manufacturing calcium diglyceroxide crystals includes at least the following steps: placing at least one calcium element source compound, in particular calcium oxide, in suspension in glycerol or in a homogeneous mixture of glycerol and an anhydrous solvent of glycerol, in particular methanol, referred to as the “starting suspension”, the molar ratio being greater than or equal to 2; milling the starting suspension at an ambient temperature of less than or equal to 50° C. in a three-dimensional liquid-phase ball mill for a holding time of 15 minutes or less; recovering, at the outlet of the mill, a suspension of calcium diglyceroxide crystals, and optionally, washing the obtained suspension with a glycerol solvent in order to eliminate any excess glycerol, optionally, drying the suspension of calcium diglyceroxide crystals so as to obtain a powder of calcium diglyceroxide crystals. Also disclosed are uses associated with the calcium diglyceroxide crystals.Type: GrantFiled: September 29, 2017Date of Patent: March 9, 2021Assignee: EASYLInventors: François Lacoste, Valentin Lair, Julien Thiel, Samy Halloumi
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Publication number: 20200139159Abstract: The present invention relates to a method for controlling a probe for the treatment of brain tissue using an assembly comprising the probe and an acoustic window (1), the probe (2) including a plurality of transducers (21) for generating ultrasound waves, the method comprising: —a phase of detection: •of the probe transducers situated above the cranium (4) of the patient, and •of the probe transducers situated above the acoustic window (1), so as to permit: •deactivation of the transducers situated above the cranium (4) of the patient, •activation of the transducers situated above the acoustic window (1).Type: ApplicationFiled: June 19, 2018Publication date: May 7, 2020Inventors: Alexandre CARPENTIER, Guillaume BOUCHOUX, Michael CANNEY, Francois LACOSTE
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Publication number: 20200138580Abstract: The present invention relates to an assembly for imaging and/or treating brain tissue, having at least one acoustic window (10) which comprises a plate (1) that is transparent to ultrasonic waves, and at least one positioning marker (2) which facilitates positioning of a probe for generating ultrasonic waves so as to be aligned with said acoustic window (10).Type: ApplicationFiled: June 19, 2018Publication date: May 7, 2020Inventors: Alexandre CARPENTIER, Guillaume BOUCHOUX, Michael CANNEY, Francois LACOSTE
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Patent number: 10603520Abstract: A device for therapeutic treatment which comprises a HIFU transducer for generating and transmitting HIFU pulses to a target. The HIFU transducer is operable in at least a probing mode, during a probing phase, and in a treatment mode, during a treatment phase. In the probing phase the HIFU transducer is operated with at least one probing operation characteristic. The probing operation characteristic includes emission of a pulse with a focal point. During the treatment phase, the HIFU transducer operates with at least one treatment operation characteristic different from the probing operation characteristic. The device further comprises a detector designed to detect a change of tissue properties caused by the HIFU pulses in the target during the probing phase. The device further comprises a computer or microprocessor for determining at least one probing parameter necessary to achieve the change of tissue properties detected by the detector during the probing phase.Type: GrantFiled: June 30, 2015Date of Patent: March 31, 2020Assignee: THERACLION SAInventors: Sylvain Yon, Francois Lacoste, Jérémie Anquez, Anthony Grisey
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Publication number: 20200031747Abstract: A method for manufacturing calcium diglyceroxide crystals includes at least the following steps: placing at least one calcium element source compound, in particular calcium oxide, in suspension in glycerol or in a homogeneous mixture of glycerol and an anhydrous glycerol solvent, in particular methanol, referred to as the “starting suspension”, the molar ratio being greater than or equal to 2; milling the starting suspension at an ambient temperature of less than or equal to 50° C. in a three-dimensional liquid-phase ball mill for a holding time of 15 minutes or less; recovering, at the outlet of the mill, a suspension of calcium diglyceroxide crystals, and optionally, washing the obtained suspension with a glycerol solvent in order to eliminate any excess glycerol, optionally, drying the suspension of calcium diglyceroxide crystals so as to obtain a powder of calcium diglyceroxide crystals. Also disclosed are uses associated with the calcium diglyceroxide crystals.Type: ApplicationFiled: September 29, 2017Publication date: January 30, 2020Inventors: François LACOSTE, Valentin LAIR, Julien THIEL, Samy HALLOUMI
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Patent number: 10533145Abstract: A method for producing fatty acid alkyl esters and glycerol implementing a set of transesterification reactions between at least one vegetable or animal oil and at least one aliphatic monoalcohol includes: introducing, into a three-dimensional microball mill at least one vegetable and/or animal oil, at least one aliphatic monoalcohol and at least one heterogenous and/or homogenous catalyst in order to form an initial mixture; grinding the initial mixture at a temperature?50° C., in a three-dimensional microball mill, for a residence time?5 minutes; recovering, at the outlet of the three-dimensional mill, a final mixture including at least fatty acid alkyl esters, glycerol, the catalyst and the aliphatic monoalcohol that has not reacted; and separating this final mixture of a first phase including the fatty acid alkyl esters and of a second phase including the glycerol, the aliphatic monoalcohol that has not reacted and the catalyst.Type: GrantFiled: June 30, 2017Date of Patent: January 14, 2020Assignee: EASYLInventors: François Lacoste, Julien Thiel, Valentin Lair, Samy Halloumi
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Publication number: 20190345413Abstract: A method for producing fatty acid alkyl esters and glycerol implementing a set of transesterification reactions between at least one vegetable or animal oil and at least one aliphatic monoalcohol includes: introducing, into a three-dimensional microball mill at least one vegetable and/or animal oil, at least one aliphatic monoalcohol and at least one heterogenous and/or homogenous catalyst in order to form an initial mixture; grinding the initial mixture at a temperature?50° C., in a three-dimensional microball mill, for a residence time?5 minutes; recovering, at the outlet of the three-dimensional mill, a final mixture including at least fatty acid alkyl esters, glycerol, the catalyst and the aliphatic monoalcohol that has not reacted; and separating this final mixture of a first phase including the fatty acid alkyl esters and of a second phase including the glycerol, the aliphatic monoalcohol that has not reacted and the catalyst.Type: ApplicationFiled: June 30, 2017Publication date: November 14, 2019Inventors: François LACOSTE, Julien THIEL, Valentin LAIR, Samy HALLOUMI
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Patent number: 10472248Abstract: Disclosed is a method for manufacturing calcium zincate crystals including: placing calcium hydroxide2 and zinc oxide, one of the precursors thereof, or one of the water mixtures thereof in a starting suspension, the mass ratio of water to calcium hydroxide and zinc oxide, or one of the precursors or mixtures thereof, being greater than or equal to 1; milling the starting suspension to an ambient temperature less than or equal to 50° C. in a wet-phase three-dimensional micro-ball mill for a residence time less than or equal to 15 minutes and in particular from 5 to 25 seconds; recovering a calcium zincate crystal suspension coming out of the mill; and optionally, concentrating or drying the calcium zincate crystal suspension so as to obtain a calcium zincate crystal powder. Also disclosed are uses associated with the calcium zincate crystals obtained according to the method described above.Type: GrantFiled: March 31, 2016Date of Patent: November 12, 2019Assignee: EASYLInventors: Francois Lacoste, Julien Thiel
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Patent number: 10420961Abstract: A method of operating a device (1) for treatment of a tissue (6) of a living being and such a device (1) including a transducer (2) comprising at least two subtransducers (2?, 2?), each for emitting a sub-beam (8?) of ultrasound waves, preferably high intensity focused ultrasound waves, for irradiating the tissue (6). Each of the sub-beams (8?) is focused on or focusable onto a focal point (F). In order to reduce skin burns, the intersection Area (Asi) of a skin surface (7) for each sub-beam (8?) is evaluated and a power (Psi) and/or a duration (tsi) of the irradiation, for every sub-transducer (2?, 2?), is determined as a rate of the total power (Ptotal) or duration (ttotal) depending from the evaluated intersection area (Asi).Type: GrantFiled: December 11, 2014Date of Patent: September 24, 2019Assignee: Theraclion SAInventor: Francois Lacoste
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Publication number: 20190263672Abstract: Disclosed is a method for manufacturing crystals of aluminates of one or more element(s) other than aluminium, referred to as “A. The method includes: placing starting reagents, including at least one aluminium element source and a source of the element(s) A that has a degree of oxidation of between 1 and 6, in suspension in a liquid medium, forming a suspension referred to as the “starting suspension”; milling the starting suspension at ?50° C., in a three-dimensional liquid medium ball mill for ?5 minutes; recovering, at the outlet of the three-dimensional ball mill, a suspension referred to as the “end suspension” including the starting reagents in activated form or crystals of aluminate of the element(s) A generally in hydrated form; if required, calcination of the end suspension when it includes the starting reagents in activated form, to obtain generally non-hydrated crystals of aluminate of the element(s) A.Type: ApplicationFiled: October 5, 2017Publication date: August 29, 2019Inventors: François LACOSTE, Valentin LAIR, Julien THIEL, Samy HALLOUMI
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Publication number: 20190134429Abstract: The present invention relates to an ultrasonic probe for heating, internally, an ultrasonically absorbent target medium, the probe comprising: at least one piezoelectric transducer (21) having a front face (212) intended to be positioned facing the target medium and a back face (211) opposite the front face (212), the transducer being able to emit at least one primary wave emanating from its front face and at least one secondary wave emanating from its back face, the probe being noteworthy in that it furthermore comprises: a reflector (24) facing the back face (211) of the transducer (21), the reflector (24) being suitable for reflecting the secondary wave emitted by the transducer (21); and a cooling-fluid layer (25) between the transducer (21) and the reflector (24).Type: ApplicationFiled: April 14, 2017Publication date: May 9, 2019Inventors: Michael CANNEY, Guillaume BOUCHOUX, Alexandre VIGNOT, Francois LACOSTE