Abstract: The present invention relates to the prevention and treatment of disease like cancer. The inventors have previously characterized MELOE-1 antigen as an IRES dependent, melanoma specific translation product from a lncRNA mainly transcribed in the melanocytic lineage. MELOE-1 contains numerous class II epitopes and one HLA-A*0201-restricted CD8 epitope eliciting a frequent repertoire of high avidity T cells. They designed various synthetic long peptide (SLPs) comprising a CD4 epitope coupled to the CD8 epitope by a serie of linkers of 4 to 6 aa and studied the efficacy of T cell clone activation by SLP-loaded DC in vitro. Particularly, they evaluated the ability of a few selected SLPs to stimulate specific T cells proliferation of PBL from healthy donors in vitro and finally, they explored the vaccination potential of their best SLP candidate in vivo in an HLA*A0201/HLA-DRB0101 transgenic mouse.

Abstract: The present invention relates to the prevention and treatment of disease like cancer. The inventors have previously characterized MELOE-1 antigen as an IRES dependent, melanoma specific translation product from a lncRNA mainly transcribed in the melanocytic lineage. MELOE-1 contains numerous class II epitopes and one HLA-A*0201-restricted CD8 epitope eliciting a frequent repertoire of high avidity T cells. They designed various synthetic long peptide (SLPs) comprising a CD4 epitope coupled to the CD8 epitope by a serie of linkers of 4 to 6 aa and studied the efficacy of T cell clone activation by SLP-loaded DC in vitro. Particularly, they evaluated the ability of a few selected SLPs to stimulate specific T cells proliferation of PBL from healthy donors in vitro and finally, they explored the vaccination potential of their best SLP candidate in vivo in an HLA*A0201/HLA-DRB0101 transgenic mouse.

Abstract: The present invention relates to a melanoma antigen peptide comprising the amino acids sequence selected in the group consisting of SEQ ID NO: 1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4 or SEQ ID NO:5 or a function-conservative variant thereof. Moreover the invention also relates to a melanoma antigen peptide according to the invention for use in the prevention or the treatment of melanoma in patient.

Abstract: The present invention relates to a melanoma antigen peptide comprising the amino acids sequence selected in the group consisting of SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14 or SEQ ID NO: 15 or a function-conservative variant thereof. Moreover the invention also relates to a melanoma antigen peptide according to the invention for use in the prevention or the treatment of melanoma in patient.

Abstract: The present invention relates to a melanoma antigen peptide comprising the amino acids sequence selected in the group consisting of SEQ ID NO: 1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4 or SEQ ID NO:5 or a function-conservative variant thereof. Moreover the invention also relates to a melanoma antigen peptide according to the invention for use in the prevention or the treatment of melanoma in patient.

Abstract: The present invention relates to a melanoma antigen peptide comprising the amino acids sequence selected in the group consisting of SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14 or SEQ ID NO: 15 or a function-conservative variant thereof. Moreover the invention also relates to a melanoma antigen peptide according to the invention for use in the prevention or the treatment of melanoma in patient.

Abstract: The application relates to antibodies which recognize the AviTag™ peptide of sequence MSGLNDIFEAQKIEWHE (SEQ ID No. 1) and to fragments thereof which recognize SEQ ID No. 1, wherein said antibodies or said fragments thereof recognize polypeptides containing SEQ ID No. 1 at their NH2 terminus and polypeptides containing SEQ ID No. 1 at their COOH terminus. The application further relates to a method for sorting target cells presenting on their surface a surface marker from a mixed cell population comprising the steps of: a) incubating said mixed cell population with a tagged adapter which binds to said surface marker of said target cells, wherein said adapter is bound to an antibody which recognizes said tag, and wherein said antibody is immobilized on a solid support. b) collecting said target cells.

Abstract: The invention concerns multimers developed from recombinant proteins analogues of MHC class I.

Abstract: The application relates to antibodies which recognize the AviTag™ peptide of sequence MSGLNDIFEAQKIEWHE (SEQ ID No. 1) and to fragments thereof which recognize SEQ ID No. 1, wherein said antibodies or said fragments thereof recognize polypeptides containing SEQ ID No. 1 at their NH2 terminus and polypeptides containing SEQ ID No. 1 at their COOH terminus. The application further relates to a method for sorting target cells presenting on their surface a surface marker from a mixed cell population comprising the steps of: a) incubating said mixed cell population with a tagged adapter which binds to said surface marker of said target cells, wherein said adapter is bound to an antibody which recognizes said tag, and wherein said antibody is immobilized on a solid support. b) collecting said target cells.

Abstract: The invention concerns multimers developed from recombinant proteins analogues of MHC class I.

Abstract: The invention concerns multimers developed from recombinant proteins analogues of MHC class I.

Abstract: A contact frame for an IC card reader including, in particular, guide means for guiding or positioning the card, together with contact elements for providing electrical connection with conducting pads on the IC card via which circuits are established to the apparatus including the IC card reader, the contact frame being characterized by the fact that it comprises an inner frame (7) of insulating material molded over the contact elements (4) for providing electrical connection to the IC card, and two extensions (17, 18) extending the substance of the inner frame (7) sideways towards the side edges of the card and beyond said edges, each of said two extensions carrying means (6, 19, 20) for defining the positions of two card-guiding slideways (21, 22).

Abstract: A protected optical disk of welded construction comprises a housing the diameter of which is its largest dimension. The housing consists of parts fabricated from a thermoplastic material joined together by at least one circular weld which occupies part of a plane annular joining area perpendicular to the axis of rotation of the disk. An internal chamber is bordered radially by this joining area. An information carrying layer is contained in this chamber. A pair of grooves lies one on either side of the portion of each of the parts included in the weld and there is a circularly disposed sharp edged projection between the grooves of each pair. In this way the grooves and the projection form a weld preform on at least one joining surface of the parts.

Abstract: A disk which carries information obtained by molding from a cut matrix is detached from the matrix by means of a gas jet injected between the disk and the cut matrix. The disk is maintained in contact with the matrix both at the periphery and at the center, means being also provided for limiting deformation of the disk while it is being removed.

Abstract: A protected optical disk for recording information is fabricated by a method whereby at least one cover is rigidly fixed by a welding to an optical disk having at least one layer of recording material which can be both written and read optically. At least two joints are thus formed by welding, each joint being constituted by at least two weld zones each located respectively within a concentric ring.

Abstract: A protected optical disc adapted for optical recording and playback of information (particularly digital recording) with a rigid element carrying the recording surface, and a flexible element permeable to optical radiation, one of these two elements having the shape of a dish. At least one of the elements is provided with a central hole for receiving a driving shaft, with the joined annular portion or portions of the two elements concentric with the central hole.

Abstract: The invention relates to protected optical disk structures. The invention relates placing the sensitive layer on a substrate, which is only joined to the other elements constituting the box by a single fixing area, located in the central part of said box, in order that deformations of the box do not affect the smoothness and flatness of the substrate.

Abstract: A disk which carries information obtained by molding from a cut matrix is detached from the matrix by means of a gas jet injected between the disk and the cut matrix. The disk is maintained in contact with the matrix both at the periphery and at the center, means being also provided for limiting deformation of the disk while it is being removed.

Abstract: The invention relates to a process for obtaining information-carrying disks by moulding from a recorded matrix. The invention makes it possible to obtain a disk having a recording area and intact areas, which are separated by stop areas. The invention more particularly applies to the production of video disks and disks useable in information technology. It facilitates the installation of covers on the disks.

Abstract: A device for projecting ink droplets through a set of projection holes to print a pattern under selective electrical or light pulse control.A first plate formed with a large number of holes is placed in close proximity to the surface of the printing medium. A second plate a small distance from the first defines therewith a chamber in which the ink is locally heated by electrical current controlled by light selectively impinging on a photoconductive part of said second plate in register with each hole or each group of holes so as to form a pattern with constant or variable parts.