Abstract: The present invention relates to methods for promoting anti-tumor immune response in a subject in need thereof using encapsulated interleukin 12 (IL-12).

Abstract: Disclosed herein are improved methods for treatment of brain cancer (such as glioma/glioblastoma) via ligand-inducible gene-switch controlled in vivo expression of an immunomodulator (i.e., IL-12) in combination with one or more other immunomodulators (i.e., an immune cell check point inhibitor; e.g., such as a PD-1 inhibitor or a PD-1 binder.

Abstract: One example of a gas turbine engine can include a first compressor and a first turbine connected to the first compressor by a first shaft. The engine can include a reheat combustor, which is disposed downstream of the first turbine, and a second turbine, which is disposed downstream of the reheat combustor. The engine can further include a second compressor, which is connected to the second turbine by a second shaft and is disposed upstream of the first compressor. The first and second turbines can be disconnected from one another, and the first and second compressors can be disconnected from one another. The second compressor may have an outlet including a flow to the first compressor, such that the first and second turbines provide a shaft worksplit. The reheat combustor can be configured to receive fuel and generate a reheat exit temperature, so as to control an apparent capacity of the second turbine based on a plurality of parameters of the second compressor.

Abstract: A method of modulating the cooling of a gas turbine component is disclosed. The method includes determining a target component temperature at which the gas turbine component can be maintained without the gas turbine component experiencing a failure over the course of an indicated life of the gas turbine component; scheduling a cooling air value to the target component temperature; and determining one or more of a demanded cooling air temperature and a demanded cooling air mass flow rate based on the scheduled cooling air value.

Abstract: One example of a gas turbine engine may include a gas generator, a reheat combustor that is disposed downstream of the gas generator, and a power turbine that is disposed downstream of the reheat combustor and includes a plurality of nozzle guide vanes. The reheat combustor is configured to increase a fuel flow so as to increase a temperature of the reheat combustor and match a required exhaust temperature. The nozzle guide vanes are configured to increase a real capacity at a power turbine inlet in proportion with the required exhaust temperature. A constant apparent capacity at a gas generator exit upstream of the reheat combustor remains constant, in response to proportionately increasing the temperature and the real capacity with respect to one another.

Abstract: A method of modulating the cooling of a gas turbine component is disclosed. The method includes determining a target component temperature at which the gas turbine component can be maintained without the gas turbine component experiencing a failure over the course of an indicated life of the gas turbine component; scheduling a cooling air value to the target component temperature; and determining one or more of a demanded cooling air temperature and a demanded cooling air mass flow rate based on the scheduled cooling air value.

Abstract: One example of a gas turbine engine can include a first compressor and a first turbine connected to the first compressor by a first shaft. The engine can include a reheat combustor, which is disposed downstream of the first turbine, and a second turbine, which is disposed downstream of the reheat combustor. The engine can further include a second compressor, which is connected to the second turbine by a second shaft and is disposed upstream of the first compressor. The first and second turbines can be disconnected from one another, and the first and second compressors can be disconnected from one another. The second compressor may have an outlet including a flow to the first compressor, such that the first and second turbines provide a shaft worksplit. The reheat combustor can be configured to receive fuel and generate a reheat exit temperature, so as to control an apparent capacity of the second turbine based on a plurality of parameters of the second compressor.

Abstract: One example of a gas turbine engine may include a gas generator, a reheat combustor that is disposed downstream of the gas generator, and a power turbine that is disposed downstream of the reheat combustor and includes a plurality of nozzle guide vanes. The reheat combustor is configured to increase a fuel flow so as to increase a temperature of the reheat combustor and match a required exhaust temperature. The nozzle guide vanes are configured to increase a real capacity at a power turbine inlet in proportion with the required exhaust temperature. A constant apparent capacity at a gas generator exit upstream of the reheat combustor remains constant, in response to proportionately increasing the temperature and the real capacity with respect to one another.

Abstract: A method for operating a multi-stage combustor of a gas turbine engine comprises: (a) determining a combustor air entry temperature; (b) determining the combustor air entry flow rate; and (c) controlling the fuel split ratio to stages of the combustor on the basis of the combustor air entry flow rate and the combustor air entry temperature.

Abstract: An elongated tension arm is provided on a wiper of a windshield wiper assembly. The tension arm biases a wiper arm of the wiper about a wiper head of the wiper. The tension arm has a tension arm head with a tension arm leg extending longitudinally therefrom. The tension arm head overlies the wiper arm head and the tension arm leg overlies the wiper arm. The tension arm head is coupled to the wiper arm head via a pair of arm members extending laterally therefrom. The arm members receive an anchoring screw therethrough which underlies the wiper arm head. The tension arm leg has a threaded hole therethrough receiving a wing screw which engages the wiper arm. Rotation of the wing screw serves to increase or decrease resilient pressure on the wiper arm.

Abstract: The compressor with variable pressure is equipped whit a head, fallowed by two arms equipped with a hole in there extremity, forming a 90 degree angle with the head of the compressor their giving them the possibilities to fallow each side of the head of supports of the windscreen wiper. So allowing by mean of one nut to anchor it after the head of support of the windscreen wiper and in this way to allow the compressor to fallow the same axis. Of a leg covering in is middle the leg of arm of support of the windscreen wiper, allowing the insertion of a nut with fin in a threaded hole situated at the end of the leg of the compressor. By turning the nut with fin downward, this gesture allows to pressurize the blade of the windscreen wiper, a pressure which obliges it to stick on the windscreen, allowing the blade to clean the windscreen with more efficiency. It eliminated the uprising of the blade induce by the strength of the wind or the speed of the car.