Abstract: The method and the device are applicable to the penetrations (2) of a pressurised water nuclear reactor vessel head (1) during operation.The device includes a double circuit for picking off two gas samples (100, 16, 17; 12, 13, 14, 15) and a measurement assembly (18) which regularly compares the content, especially of water vapour, in the two samples picked off. The first sample is taken from the volume of a chamber (7) where the possible leak (10) emerges, and the second in proximity to the head (1) outside the region immediately affected by the leak. The assembly (18) makes it possible to generate (19) an alarm in the event of a leak and to distinguish it from operational alarms.Techniques and means are also provided for determining the flow rate of sweeping in the volume of the chamber (7) and for checking the pick-off and detection systems.