Abstract: A head-mounted display device may initiate display of a user interface on a display of the head-mounted display device. A head-mounted display device may compute an angular distance between a previous head orientation and a current head orientation based on head movement data. A head-mounted display device may apply a gain value to the angular distance to move a position indicator to an updated position within a boundary of the user interface, the user interface configured to remain fixed to a location in the display regardless of head movements.

Abstract: Techniques of operating an AR system include determining hand gestures formed by a user based on a sequence of two-dimensional images through skin of the user's wrist acquired from a near-infrared camera. Specifically, an image capture device disposed on a band worn around a user's wrist includes a source of electromagnetic radiation, e.g., light-emitting diodes in the infrared (IR) wavelength band that emit the radiation into the user's wrist and an IR detector which produces the sequence of two-dimensional images of a region within a dermal layer in the user's wrist. From this sequence, gesture detection circuitry determines values of a biological flow metric, e.g., a change in perfusion index (PI) between frames of the sequence, based on a trained model that generates the metric from the sequence. Finally, the gesture detection circuitry maps the values of the biological flow metric to specific hand/finger movements that determine a gesture.

Abstract: A head-mounted device may present a first user interface element and a second user interface element within a user interface that is included in a display of the head-mounted device. The head-mounted device may, in response to movement of the head-mounted device, move the first user interface element and the second user interface element within the display, the movement of the first user interface element decreasing a boundary distance below a threshold distance, the boundary distance being based on a distance between the first user interface element and a boundary associated with the user interface. The head-mounted device may decrease a size of the first user interface element while the boundary distance is decreasing and is below the threshold distance.

Abstract: A head-mounted device may present a first user interface element and a second user interface element within a user interface that is included in a display of the head-mounted device. The head-mounted device may, in response to movement of the head-mounted device, move the first user interface element and the second user interface element within the display, the movement of the first user interface element decreasing a boundary distance below a threshold distance, the boundary distance being based on a distance between the first user interface element and a boundary associated with the user interface. The head-mounted device may decrease a size of the first user interface element while the boundary distance is decreasing and is below the threshold distance.

Abstract: Techniques include determining hand gestures formed by a user based on an electrical impedance tomograph of the wrist. For example, a user may be outfitted with a flexible wristband that fits snugly around the wrist and contains a plurality of electrodes, e.g., 32 electrodes. When a current is applied to a first subset of the electrodes, e.g., two of 32 electrodes, the electric field induced through at least one cross-section of the wrist will in turn induce a voltage across adjacent pairs of a second subset of the electrodes (e.g., the other 30 of 32 electrodes). From this current and induced voltage, one may use techniques of electrical impedance tomography (EIT) to determine the electrical impedance throughout the at least one cross-section of the wrist, e.g., in an electrical impedance tomograph. One may use a neural network to map the electrical impedance tomograph to a hand gesture.

Abstract: Techniques of operating an AR system include determining hand gestures formed by a user based on a sequence of two-dimensional images through skin of the user's wrist acquired from a near-infrared camera. Specifically, an image capture device disposed on a band worn around a user's wrist includes a source of electromagnetic radiation, e.g., light-emitting diodes in the infrared (IR) wavelength band that emit the radiation into the user's wrist and an IR detector which produces the sequence of two-dimensional images of a region within a dermal layer in the user's wrist. From this sequence, gesture detection circuitry determines values of a biological flow metric, e.g., a change in perfusion index (PI) between frames of the sequence, based on a trained model that generates the metric from the sequence. Finally, the gesture detection circuitry maps the values of the biological flow metric to specific hand/finger movements that determine a gesture.

Abstract: Techniques of operating an AR system include determining hand gestures formed by a user based on a sequence of two-dimensional images through skin of the user's wrist acquired from a near-infrared camera. Specifically, an image capture device disposed on a band worn around a user's wrist includes a source of electromagnetic radiation, e.g., light-emitting diodes in the infrared (IR) wavelength band that emit the radiation into the user's wrist and an IR detector which produces the sequence of two-dimensional images of a region within a dermal layer in the user's wrist. From this sequence, gesture detection circuitry determines values of a biological flow metric, e.g., a change in perfusion index (PI) between frames of the sequence, based on a trained model that generates the metric from the sequence. Finally, the gesture detection circuitry maps the values of the biological flow metric to specific hand/finger movements that determine a gesture.

Abstract: The present invention relates to a modified oligonucleotide having two or more thiol functions, which can be immobilized on a gold surface or on a grafted surface, in particular a surface comprising at least one carbon-carbon double bond or carbon-carbon triple bond or haloacetamide functions, preferably maleimide or acrylamide functions. The invention also relates to a method for detecting a nucleic acid in a biological sample comprising a step of detecting hybridization between a modified oligonucleotide and a target nucleic acid amplified from the biological sample. The invention relates more particularly to a method for detecting, genotyping or sequencing a pathogenic organism, preferably a virus.

Abstract: The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also relates to an oligonucleotide grafted by such a compound, thus having one or more thiol functions, suitable for being immobilized on a gold surface or on a grafted surface.

Abstract: The present invention relates to a modified oligonucleotide having two or more thiol functions, which can be immobilized on a gold surface or on a grafted surface, in particular a surface comprising at least one carbon-carbon double bond or carbon-carbon triple bond or haloacetamide functions, preferably maleimide or acrylamide functions. The invention also relates to a method for detecting a nucleic acid in a biological sample comprising a step of detecting hybridization between a modified oligonucleotide and a target nucleic acid amplified from the biological sample. The invention relates more particularly to a method for detecting, genotyping or sequencing a pathogenic organism, preferably a virus.

Abstract: A molecule responding to formula (I) of the glycocluster type with galactose residues at their extremities. Simple and efficient methods for the preparation of these compounds. Medical use of compounds (I) as inhibitors of infections by Pseudomonas aeruginosa, more specifically as inhibitors of Pseudomonas aeruginosa's virulence.

Abstract: The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also relates to an oligonucleotide grafted by such a compound, thus having one or more thiol functions, suitable for being immobilized on a gold surface or on a grafted surface.

Abstract: The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also relates to an oligonucleotide grafted by such a compound, thus having one or more thiol functions, suitable for being immobilized on a gold surface or on a grafted surface.

Abstract: A molecule responding to formula (I)of the glycocluster type with galactose residues at their extremities. Simple and efficient methods for the preparation of these compounds. Medical use of compounds (I) as inhibitors of infections by Pseudomonas aeruginosa, more specifically as inhibitors of Pseudomonas aeruginosa's virulence.

Abstract: The present invention relates to a modified oligonucleotide having two or more thiol functions, which can be immobilized on a gold surface or on a grafted surface, in particular a surface comprising at least one carbon-carbon double bond or carbon-carbon triple bond or haloacetamide functions, preferably maleimide or acrylamide functions. The invention also relates to a method for detecting a nucleic acid in a biological sample comprising a step of detecting hybridization between a modified oligonucleotide and a target nucleic acid amplified from the biological sample. The invention relates more particularly to a method for detecting, genotyping or sequencing a pathogenic organism, preferably a virus.

Abstract: The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also relates to an oligonucleotide grafted by such a compound, thus having one or more thiol functions, suitable for being immobilized on a gold surface or on a grafted surface.

Abstract: This invention relates to a process for preparing an oligonucleotide 5?-triphosphate.

Abstract: A solution phase synthesis method for preparing an oligonucleotide, wherein at least some of the reagents are solid supported. The method suitable for large-scale synthesis comprises coupling a protected compound with a nucleotide derivative having a protection group in the presence of a solid supported activator to give an elongated oligonucleotide with a P(III)-internucleotide bond; optionally processing the elongated oligonucleotide by capping by reaction with a solid supported capping agent and/or by oxidizing or sulfurizing by reaction of the oligonucleotide with a solid supported oxidizing or sulfurization reagent; and removing the protection group. The coupling may include reacting a 3?-protected compound of formula: with a nucleotide derivative having a 5?-protection group, or reacting a 5?-protected compound of formula with a nucleotide derivative having a 3?-protection group.

Abstract: The present invention describes simple, efficient, and enzyme-free method of making oligonucleotides with 5?-triphosphate. This invention presents novel process for synthesizing triphosphate oligonucleotides using a diaryl phosphonate as reagent. The process of the present invention is amenable to large-scale, economic 5?-triphosphate oligonucleotide synthesis.

Abstract: Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistry” reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.