Abstract: A data processing system implements receiving, in a first silo, configuration parameters for performing federated training of the machine learning model using data stored in the plurality of second silos, generating a federated learning pipeline for automatically executing a plurality of tasks associated with the federated learning of the machine learning model based on the configuration parameters, causing each respective silo of the plurality of second silos to train the local instance of the machine learning model according to the federated learning pipeline, obtaining, at the first silo, the learnable parameters information associated with the local instance of the machine learning model of each silo of the plurality of second silos, and aggregating the learnable parameters information obtained from the plurality of second silos to obtain a primary instance of the machine learning model that has been fine-tuned according to the learnable parameters information.

Abstract: Devices and methods provided for joint arthroscopy contemplate and enable the provision of patient specific instruments (PSI). The devices and anatomical features of a patient are rendered adjustable by the provision of conforming surfaces and support elements to account for and enable repositioning of the anatomical features during surgery. Where the joint arthroscopy involves shoulder arthroplasty, a PSI system includes at least one shoulder PSI operable to be positioned on a bone in a shoulder in the patient. The at least one shoulder PSI allow for the transfer of preoperative planning to intra-operative procedures. The at least one shoulder PSI may be virtually designed as a model based on scan data of the bone in the shoulder of the patient. The at least one shoulder PSI may be fabricated based on the virtually-designed at least one shoulder PSI model.

Abstract: A liquid hand dishwashing cleaning composition has a surfactant system. The surfactant system has an anionic surfactant and a nonionic surfactant package. The weight ratio of the nonionic surfactant to the anionic surfactant is greater than or equal to 1:1. The nonionic surfactant package has a mixture of a first nonionic surfactant and a second nonionic surfactant, wherein the first nonionic surfactant includes an alkyl polyglucoside surfactant. The surfactant system further includes a co-surfactant selected from the group consisting of amphoteric surfactant, zwitterionic surfactant, and mixtures thereof. The weight ratio of the anionic surfactant to the co-surfactant is from 1.0:1 to 2.4:1. The weight ratio of the first nonionic surfactant to the second nonionic surfactant is from 3:1 to 1:3.

Abstract: A liquid hand dishwashing cleaning composition has a surfactant system in a level of from 15% to 40% by weight of the composition. The surfactant system has an anionic surfactant, a co-surfactant, and less than or equal to 18.4% of a nonionic surfactant package by weight of the composition. The weight ratio of the nonionic surfactant to the anionic surfactant is from 1:1 to 3:1. The nonionic surfactant package has a mixture of a first nonionic surfactant and a second nonionic surfactant. The first nonionic surfactant comprises an alkyl polyglucoside surfactant. The weight ratio of the anionic surfactant to the co-surfactant ranges from 1:1 to 8:1. The weight ratio of the first nonionic surfactant to the second nonionic surfactant ranges from 3:1 to 1:3.

Abstract: A liquid hand dishwashing cleaning composition having from 15% to 40% by weight of the composition of a surfactant system. The surfactant system has an anionic surfactant and from 5% to 18.4% of a nonionic surfactant package by weight of the composition. The weight ratio of the nonionic surfactant package to the anionic surfactant ranges from 1:1 to 3:1. The nonionic surfactant has a mixture of a first nonionic surfactant and a second nonionic surfactant. The first nonionic surfactant includes an alkyl polyglucoside surfactant. The surfactant system further includes a co-surfactant. The weight ratio of the anionic surfactant to the co-surfactant ranges from 1:1 to 8:1. The composition is free of fatty acid or salts thereof.

Abstract: An apparatus and a method are provided for a patient-specific instrument guide for arthroplasty or other operations on bone tissue, capable of limiting bone cuts, achieving optimal implant positioning, and providing improved stability of implants. The patient-specific instrument guide comprises a body that includes a bone contact surface configured to contact a bone surface of a patient. The body is configured to be 3D printed according to medical imaging of a patient's anatomy, such that the bone contact surface optimally contacts the surface of the patient's bone. The body includes one or more guide slots that each slidably receives a cutting guide. The cutting guides are configured to receive a saw blade during bone cutting. The cutting guides may be oriented to guide cutting a talus or a tibia during a total ankle arthroplasty surgery.

Abstract: Devices and methods provided for joint arthroscopy contemplate and enable the provision of patient specific instruments (PSI). The devices and anatomical features of a patient are rendered adjustable by the provision of guide elements and feature to account for and enable repositioning of the anatomical features during surgery. Where the joint arthroscopy involves ankle arthroplasty, a PSI system includes a tibial PSI operable to be coupled to a tibia and a talar PSI operable to be coupled to a talus. Pins pass through the tibial PSI into the tibia and through the talar PSI into the talus. The tibia and talus are aligned based on the tibial PSI, the talar PSI, the pins, and optionally a connection guide operable to receive, or be coupled to, the pins. The tibial PSI and the talar PSI allow for the transfer of pre-operative planning to intra-operative procedures.

Abstract: A preform has a fibrous reinforcement woven in one piece by three-dimensional weaving to create a fan inter-blade platform The platform includes an aerodynamic base and a fixing structure having stiffening elements that extend from the aerodynamic base. The preform includes a first fibrous part configured to form the aerodynamic base, second fibrous part configured to at least partially form the stiffening elements of the inter-blade platform, a first connection zone in which the first and second parts are woven together, and a first disconnection zone delimited by a first disconnection line extending in a transverse direction and in which the first and second parts are separated from one another. The first disconnection zone is adjacent to the first connection zone in a longitudinal direction L.

Abstract: The present invention relates to Cyclic Phosphate Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, Q, V, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising a Cyclic Phosphate Substituted Nucleoside Derivative, and methods of using the Cyclic Phosphate Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.

Abstract: The invention relates to a de-icing device designed to supply de-icing air to a turbomachine separation nozzle extending along a longitudinal axis, the turbomachine comprising:—the separation nozzle which is designed to be positioned downstream from a turbomachine fan and comprises an internal casing and an external casing which form a separation between a primary flow vein for a primary stream and a secondary flow vein for a secondary stream, said streams issuing from the fan, the internal casing and the external casing defining an inter-vein space;—turbomachine guide vanes designed to be secured by screws to the internal casing such that the screws extend into the inter-vein space, the de-icing device being intended to be positioned in the inter-vein space and comprising—an air inlet;—an air outlet;—a plurality of channels extending from the air inlet toward the air outlet; the channels being arranged in relation to one another such that they are designed to extend from the air inlet toward the air outlets,

Abstract: A turbine engine fan having an axis of revolution wherein a fan disk having an upstream face and a radial face is configured to receive a series of fan blades. An inter-blade platform wherein an upstream end, a blocking ferrule, are applied and attached on the one hand to the upstream end of the platform and on the other hand to the upstream face of the fan disk, and an inlet cone. The blocking ferrule includes a radial ring and a lug, extending axially from the radial ring and configured to form a radial abutment for the inlet cone.

Abstract: A fan includes: a fan disc; an inter-blade platform including a base and a radial tab, a second orifice being formed in the tab of the platform; and a lock having a downstream edge configured to bear against the tab of the platform. The one among the downstream edge and the yoke of the fan disc includes a pin, the other includes a first orifice, the pin being configured to enter the first orifice and the second orifice so as to block the platform relative to the fan disc.

Abstract: An implantable ankle-prosthesis component (1), comprising a main body (2) with a bone contact face (3) intended to come into contact with an area of a bone body of an ankle and extending along a median contact plane (Pc), and comprising a anchoring means (4) protruding from the bone contact face (3), the anchoring means (4) comprising two pairs (20A, 20B) of anchoring wings, each extending in a plane (P1, P2), respectively, orthogonal to said median contact plane (Pc) between a first end (23A, 23B) connected to said bone contact face (3) and an opposite second end (24A, 24B), the planes of extension (P1, P2) of the pairs (20A, 20B) of anchoring wings intersecting each other, said second ends (24A, 24B) of the pairs (20A, 20B) of anchoring wings being inscribed in a leading plane (Pa) inclined with respect to said median contact plane (Pc).

Abstract: The present invention is directed carbocyclic nucleoside reverse transcriptase inhibitors compounds of Formula I and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC.

Abstract: The invention concerns an ankle prosthesis (100), comprising a talar component (200) which includes a talar upper face (201) defining a first articular surface (202) and which extends between a talar anterior edge (203) and an opposite talar posterior edge (204) according to a first average direction, said first articular surface (202) being curved according to said first average direction, said first articular surface (202) comprising a first curved portion (202A) and a second curved portion (202B), each extending according to said first average direction, said first curved portion (202A) having a first curvature and said second curved portion (202B) having a second curvature, said prosthesis (100) being characterized in that said first curved portion (202A) and said second curved portion (202B) define respectively an anterior portion and a posterior portion of said first articular surface (202), said first curvature being greater than said second curvature.

Abstract: The present invention relates to Cyclic Phosphate Substituted Nucleoside Compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein in A, B, R1, R2, R3, Q and V are as defined herein. The present invention also relates to compositions comprising a Cyclic Phosphate Substituted Nucleoside Compound, and methods of using the Cyclic Phosphate Substituted Nucleoside Compounds for treating or preventing HCV infection in a patient.

Abstract: A turbine engine is provided with a longitudinal rotation axis having at least one shaft with a radial axis, in particular a pitch change system for the blades of a propeller, said shaft traversing a radial passage of a substantially cylindrical case around the longitudinal axis. The turbine engine includes an annular oil guiding device around the radial shaft. The device has first and second annular parts nested in one another and secured to one another by hooping. The first part is secured by hooping to the radial shaft, and the second part is configured so as to be separated from the first part under the action of a force oriented along the radial axis and exerted on the second part by a member of the turbine engine forming a stop during a radial movement of the radial shaft.

Abstract: The present invention relates to Cyclic Phosphate Substituted Nucleoside Derivatives of Formula (I), and pharmaceutically acceptable salts thereof, wherein A, B, Q, V, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising a Cyclic Phosphate Substituted Nucleoside Derivative, and methods of using the Cyclic Phosphate Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.

Abstract: A turbine engine fan having an axis of revolution wherein a fan disk having an upstream face and a radial face is configured to receive a series of fan blades. An inter-blade platform wherein an upstream end, a blocking ferrule, are applied and attached on the one hand to the upstream end of the platform and on the other hand to the upstream face of the fan disk, and an inlet cone. The blocking ferrule includes a radial ring and a lug, extending axially from the radial ring and configured to form a radial abutment for the inlet cone.

Abstract: A method and system for cooling air within an enclosure. The enclosure includes a cooling system and a remaining portion of the enclosure that is external to the cooling system. An outside air temperature of air entering the cooling system from outside the enclosure is monitored. A blowing air temperature of air in the cooling system at the outlet of the cooling system is monitored. A first inlet of the enclosure is controlled to be fully open or fully closed, in dependence on the monitored outside air temperature. A second inlet of the enclosure is controlled by adjusting an amount of opening of the second inlet, in dependence on the monitored blowing air temperature. A valve in a secondary water circuit of the cooling mechanism is controlled by adjusting an amount of opening of the valve, in dependence on the monitored outside air temperature.