Patents by Inventor Francois Soucy

Francois Soucy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of clasto-lactacystin &bgr;-lactone and analogs thereof
    Patent number: 6294560
    Abstract: The present invention is directed to an improved synthesis of clasto-lactacystin-&bgr;-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-&bgr;-lactones, and analogs thereof and their use as proteosome inhibitors.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: September 25, 2001
    Assignee: Millennium Pharmaceuticals, Inc..
    Inventors: François Soucy, Louis Plamondon, Mark Behnke, William Roush
  • Treatment of infarcts
    Patent number: 6271199
    Abstract: This invention is directed to treating ischemia by administering proteasome inhibitors, ubiquitin pathway inhibitors, agents that interfere with the activation of NF-&kgr;B via the ubiquitin proteasome pathway, or mixtures thereof.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: August 7, 2001
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Stephen J Brand, Alfred L. Goldberg, Louis Plamondon, Francois Soucy, Peter J. Elliott
  • TREATMENT OF INFARCTS
    Publication number: 20010002391
    Abstract: This invention is directed to treating ischemia by administering proteasome inhibitors, ubiquitin pathway inhibitors, agents that interfere with the activation of NF-&kgr;B via the ubiquitin proteasome pathway, or mixtures thereof.
    Type: Application
    Filed: February 17, 1998
    Publication date: May 31, 2001
    Inventors: STEPHEN BRAND, ALFRED L. GOLDBERG, LOUIS PLAMONDON, FRANCOIS SOUCY, PETER J. ELLIOTT