Patents by Inventor Francois Traincard

Francois Traincard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polyclonal antibodies specific for serogroup X of N. meningitidis and uses thereof in diagnosis
    Patent number: 11618781
    Abstract: The present invention is directed to polyclonal antibodies, specific for the capsular polysaccharides of Neisseria meningitidis serogroup X (NmX), wherein said antibodies are suitable for in vitro detection of Neisseria meningitidis serogroup X in biological fluids without culture. The invention also concerns said polyclonal antibodies in different diagnostic tests and methods, in order to detect NmX. The invention discloses also a rapid diagnostic test for detecting NmX in a biological fluid, as well as a method for obtaining polyclonal antibodies useful for detecting NmX in biological fluids such as cerebrospinal fluid, serum and urine.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: April 4, 2023
    Assignee: INSTITUT PASTEUR
    Inventors: Muhamed-Kheir Taha, Alain Agnememel, Francois Traincard, Laurence Mulard
  • POLYCLONAL ANTIBODIES SPECIFIC FOR SEROGROUP X OF N. MENINGITIDIS AND USES THEREOF IN DIAGNOSIS
    Publication number: 20210095009
    Abstract: The present invention is directed to polyclonal antibodies, specific for the capsular polysaccharides of Neisseria meningitidis serogroup X (NmX), wherein said antibodies are suitable for in vitro detection of Neisseria meningitidis serogroup X in biological fluids without culture. The invention also concerns said polyclonal antibodies in different diagnostic tests and methods, in order to detect NmX.
    Type: Application
    Filed: September 30, 2020
    Publication date: April 1, 2021
    Inventors: Muhamed-Kheir TAHA, Alain AGNEMEMEL, Francois TRAINCARD, Laurence MULARD
  • Polyclonal antibodies specific for serogroup x of and uses thereof in diagnosis
    Patent number: 10822398
    Abstract: Polyclonal antibodies specific for serogroup X of N. meningitidis and uses thereof in diagnosis. The present invention is directed to polyclonal antibodies, specific for the capsular polysaccharides of Neisseria meningitidis serogroup X (NmX), wherein said antibodies are suitable for in vitro detection of Neisseria meningitidis serogroup X in biological fluids without culture. The invention also concerns said polyclonal antibodies in different diagnostic tests and methods, in order to detect Nm X. The invention discloses also a rapid diagnostic test for detecting NmX in a biological fluid, as well as a method for obtaining polyclonal antibodies useful for detecting NmX in biological fluids such as cerebrospinal fluid, serum and urine.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: November 3, 2020
    Assignee: INSTITUT PASTEUR
    Inventors: Muhamed-Kheir Taha, Alain Agnememel, Francois Traincard, Laurence Mulard
  • Glycoconjugates and their use as potential vaccines against infection by
    Patent number: 10376593
    Abstract: The present invention relates to a conjugate comprising an oligo- or polysaccharide selected from the group consisting of: (X)x-{BCDA}n-(Y)y (X)x-{CDAB}n-(Y)y (X)x-{DABC}n-(Y)y (X)x-{ABCD}n-(Y)y wherein A, B, C, D, X and Y, x, y and n are as defined in claim 1, said oligo- or polysaccharide being bound to a carrier.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: August 13, 2019
    Inventors: Laurence Mulard, Pierre Chassagne, Philippe Sansonetti, Armelle Phalipon, Francois Traincard, Farida Nato
  • POLYCLONAL ANTIBODIES SPECIFIC FOR SEROGROUP X OF N. MENINGITIDIS AND USES THEREOF IN DIAGNOSIS
    Publication number: 20170334975
    Abstract: Polyclonal antibodies specific for serogroup X of N. meningitidis and uses thereof in diagnosis. The present invention is directed to polyclonal antibodies, specific for the capsular polysaccharides of Neisseria meningitidis serogroup X (NmX), wherein said antibodies are suitable for in vitro detection of Neisseria meningitidis serogroup X in biological fluids without culture. The invention also concerns said polyclonal antibodies in different diagnostic tests and methods, in order to detect Nm X. The invention discloses also a rapid diagnostic test for detecting NmX in a biological fluid, as well as a method for obtaining polyclonal antibodies useful for detecting NmX in biological fluids such as cerebrospinal fluid, serum and urine.
    Type: Application
    Filed: November 17, 2015
    Publication date: November 23, 2017
    Inventors: Muhamed-Kheir TAHA, Alain AGNEMEMEL, Francois TRAINCARD, Laurence MULARD
  • GLYCOCONJUGATES AND THEIR USE AS POTENTIAL VACCINES AGAINST INFECTION BY SHIGELLA FLEXNERI
    Publication number: 20150290331
    Abstract: The present invention relates to a conjugate comprising an oligo- or polysaccharide selected from the group consisting of: (X)x-{BCDA}n-(Y)y (X)x-{CDAB}n-(Y)y (X)x-{DABC}n-(Y)y (X)x-{ABCD}n-(Y)y wherein A, B, C, D, X and Y, x, y and n are as defined in claim 1, said oligo- or polysaccharide being bound to a carrier.
    Type: Application
    Filed: October 29, 2013
    Publication date: October 15, 2015
    Inventors: Laurence Mulard, Pierre Chassagne, Philippe Sansonetti, Armelle Phalipon, Francois Traincard, Farida Nato
  • Methods of identifying NF-?B inhibitors
    Patent number: 8790883
    Abstract: The present invention relates to polypeptides that inhibit the NF-?B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: July 29, 2014
    Assignee: Institut Pasteur
    Inventors: Fabrice Agou, Gilles Courtois, Alain Israel, Michel Vernon, Francois Traincard, Shoji Yamaoka
  • Identification of substances that inhibit NEMO oligomerization
    Patent number: 7842462
    Abstract: The present invention provides methods for screening for substances which inhibit the oligomerization of NEMO and/or IKK-related complexes and/or signaling pathways based on the interference with NEMO oligomerization.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: November 30, 2010
    Assignee: Institut Pasteur
    Inventors: Francois Traincard, Fabrice Agou, Michel Veron
  • Selective inhibition of NF-?B activation by peptides designed to disrupt nemo oligomerization
    Patent number: 7700553
    Abstract: The present invention relates to polypeptides that inhibit the NF-&kgr;B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: April 20, 2010
    Assignees: Institut Pasteur, INSERM (Institut National de la Sante et de la Recherche Medicale), Centre National De La Recherche Scientifique
    Inventors: Fabrice Agou, Gilles Courtois, Alain Israel, Michel Veron, Francois Traincard, Shoji Yamaoka, Yves-Marie Coic, Francoise Baleux
  • IDENTIFICATION OF SUBSTANCES THAT INHIBIT NEMO OLIGOMERIZATION
    Publication number: 20090269748
    Abstract: The present invention provides methods for screening for substances which inhibit the oligomerization of NEMO and/or IKK-related complexes and/or signaling pathways based on the interference with NEMO oligomerization
    Type: Application
    Filed: June 13, 2008
    Publication date: October 29, 2009
    Applicant: INSTITUT PASTEUR
    Inventors: Francois Traincard, Fabrice Agou, Michel Veron
  • Selective Inhibition of Nf-Kappab Activiation by Peptides Designed to Disrupt Nemo Oligomerization
    Publication number: 20080242601
    Abstract: The present invention relates to polypeptides that inhibit the NF-&kgr; B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.
    Type: Application
    Filed: September 24, 2004
    Publication date: October 2, 2008
    Applicants: Institute Pasteur, Inserm (Inst.Nat.de la Sante et de la Rech.Med., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Fabrice Agou, Gilles Courtois, Alain Israel, Michel Veron, Francois Traincard, Shoji Yamaoka, Yves-Marie Coic, Francoise Baleux
  • SELECTIVE INHIBITION OF NF-kappaB ACTIVIATION BY PEPTIDES DESIGNED TO DISRUPT NEMO OLIGOMERIZATION
    Publication number: 20080207517
    Abstract: The present invention relates to polypeptides that inhibit the NF-?B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.
    Type: Application
    Filed: April 24, 2008
    Publication date: August 28, 2008
    Applicant: INSTITUT PASTEUR
    Inventors: Fabrice AGOU, Gilles Courtois, Alain Israel, Michel Vernon, Francois Traincard, Shoji Yamaoka
  • Identification of substances that inhibit NEMO oligomerization
    Patent number: 7413863
    Abstract: The present invention provides methods for screening for substances which inhibit the oligomerization of NEMO and/or IKK-related complexes and/or signaling pathways based on the interference with NEMO oligomerization.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: August 19, 2008
    Assignee: Institut Pasteur
    Inventors: Francois Traincard, Fabrice Agou, Michel Veron
  • NF-?B peptides designed to disrupt NEMO oligomerization
    Patent number: 7390872
    Abstract: The present invention relates to polypeptides that inhibit the NF-?B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: June 24, 2008
    Assignee: Institut Pasteur
    Inventors: Fabrice Agou, Gilles Courtois, Alain Israel, Michel Veron, Francois Traincard, Shoji Yamaoka
  • IDENTIFICATION OF SUBSTANCES THAT INHIBIT NEMO OLIGOMERIZATION
    Publication number: 20080050763
    Abstract: The present invention provides methods for screening for substances which inhibit the oligomerization of NEMO and/or IKK-related complexes and/or signaling pathways based on the interference with NEMO oligomerization
    Type: Application
    Filed: June 8, 2007
    Publication date: February 28, 2008
    Applicant: INSTITUT PASTEUR
    Inventors: Francois TRAINCARD, Fabrice Agou, Michel Veron
  • Selective inhibition of NF-kappaB activation by peptides designed to disrupt NEMO oligomerization
    Publication number: 20050220792
    Abstract: The present invention relates to polypeptides that inhibit the NF-?B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.
    Type: Application
    Filed: September 24, 2004
    Publication date: October 6, 2005
    Applicant: INSTITUT PASTEUR
    Inventors: Fabrice Agou, Gilles Courtois, Alain Israel, Michel Veron, Francois Traincard, Shoji Yamaoka
  • Non-radioactive labelled single-stranded probe, method for manufacturing it and method for detecting a specified nucleotide sequence using this probe
    Patent number: 4978749
    Abstract: The invention relates to a new probe for detecting a specified nucleic acid sequence. It consists of a recombinant DNA containing an insert complementary to the nucleic acid sequence to be detected and nuclecic acid sequences derived from the DNA (+) of phage M13, the bases which participate in the composition of this recombinant DNA, in particular the thymine groups, being replaced by 5-bromouracil groups. The invention also relates to a method for manufacturing this probe, this method comprising the culturing of cell hosts, more especially E. coli, which are auxotrophic for thymine in a medium containing a limiting concentration of thymine and containing 5-bromouracil. After the requisite incubation time, the supernatant is removed and the probe is recovered from the bacterial cells.
    Type: Grant
    Filed: July 11, 1989
    Date of Patent: December 18, 1990
    Assignees: Institute Pasteur, Centre National de la Recherche Scientifique
    Inventors: Avrameas Stratis, Hiroshi Sakamoto, Francois Traincard, Tuyen Vo Quang, Jean-Luc Guesdon, Therese Ternynck