Abstract: The invention relates to a platinum-(II)-diamine complex having the formula et out below: ##STR1## to a method for the preparation of said compound, to a preparation with an antitumour action containing said compound, to shaped preparations with an antitumour action and to shaped preparations with an antitumour containing said compound.

Abstract: The invention relates to a platinum-(IV)-diamine complex of the formula: ##STR1## to a method for the preparation of said compound and to a preparation with an antitumor action containing said compound. Further said preparations with an antitumor action containing said compounds are disclosed.

Abstract: This invention relates to novel-platinum (IV)-diamine complexes, a pharmaceutical composition using the novel complexes and methods of treating malignant tumors in mice using the pharmaceutical composition.

Abstract: Platinum diamine complexes of the general formulae ##STR1## wherein R.sub.1 and R.sub.2 independently from each other are a hydrogen atom or a substituted or unsubstituted alkyl, cyclo-alkyl, aryl or aralkyl group, while R.sub.1 and R.sub.2 may be together a substituted or unsubstituted cyclo-alkyl group, R.sub.3 and R.sub.4 independently of each other are a hydrogen atom or a substituted or unsubstituted alkyl, aryl or aralkyl group and X is a chlorine, bromine or iodine atom, a sulphate radical, a substituted or unsubstituted carboxylate rest like an acetate or substituted acetate radical, an oxalate, malonate, hydroxymalonate or otherwise substituted malonate group or a carboxylate group, the group Y, independently from X is a chlorine, bromine or iodine atom, a hydroxyl group, a nitrate group of a carboxylate group have been found to exhibit antitumor activity together with little or none kidney toxicity and are thus of interest as a medicament.

Abstract: Platinum(IV)-diamine-complexes, a process for the preparation thereof, a process for the preparation of a medicine using such a platinum(IV)-diamine-complex for the treatment of malignant tumors in mice as well as the shaped medicine thus obtained.This invention relates to novel platinum-diamine complexes, a pharmaceutical composition using the novel complexes and methods of treating malignant tumors in mice using the pharmaceutical composition.

Abstract: This invention relates to novel platinum-diamine complexes having the formula: ##STR1## wherein R.sub.1 and R.sub.2 independently of each other may be selected from the group consisting of hydrogen, an alkyl group having 1-20 carbon atoms, a cycloalkyl group having from 3-7 carbon atoms in the ring, an aralkyl group, and an aryl group having 1-20 carbon atoms, whereas R.sub.1 and R.sub.2 together may form a cycloalkyl group having 3-7 carbon atoms in the ring and having the formula: ##STR2## wherein N is 2 to 7 and wherein R.sub.3 and R.sub.4 independently of each other are selected from the group consisting of hydrogen, an alkyl group having 1-20 carbon atoms, an aryl group or an aralkyl group having 1-20 carbon atoms in the alkyl group and X is an anionic group, providing that when X is either chlorine or malonate, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are not each H; when X is chlorine and R.sub.1 and R.sub.2 are each H, R.sub.3 and R.sub.4 are not each methyl; when X is chlorine and R.sub.1 and R.sub.

Abstract: In the process for the preparation of alkyl tin halides by means of direct conversion of tin with aliphatic halides, the alkyl halide is fed in such a way gradually to the gas space over the further reaction components that there is an overpressure of no more than a few cms of mercury. The reaction is carried out in the presence of a liquid acid amide in quantities of 0.65 to 2.3 mol per gramatom of tin and in the presence of catalytic amounts of iodine and/or iodide at raised temperatures. The reaction is promoted under the influence of ultraviolet irradiation and by the addition of a catalyst of the type promoting free radial initiation reactions. SUBACKGROUND OF THE INVENTIONThe invention relates to the preparation of alkyl tin halides by means of direct conversion of tin with aliphatic halides under the influence of liquid compounds of the acid amide type and of iodine and/or iodide as a catalyst.

Abstract: The preparation of alkyl tin halides is carried out by direct conversion of a gaseous lower aliphatic halide with a stannous halide in the presence of a nitrogenous solvent of the acid amide type at substantially atmospheric pressure. The acid amide solvent is present in quantities of approximately 1-4 mol per mol stannous halide. This reaction proceeds without the production of any trialkyl tin compounds as by-products.