Patents by Inventor FRANCOIS WILHELM

FRANCOIS WILHELM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for treatment of cancer
    Patent number: 10576050
    Abstract: The invention discloses a method of treating cancer refractory to an anticancer agent comprising administering to a cancer patient a pharmaceutical composition comprising at least one compound of Formula 1 Where R1 is selected from the group consisting of —NH2, —NH—CH2—COOH, —NH—CH(CH3)—COOH, —NH—C(CH3)2—COOH, —NH—CH2—CH2—OH and —N—(CH2CH2OH)2 or a pharmaceutically acceptable salt of such a compound, and an anticancer agent.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: March 3, 2020
    Assignee: ONCONOVA THERAPEUTICS, INC.
    Inventors: Manoj Maniar, Azra Raza, Francois Wilhelm
  • METHODS AND COMPOSITIONS FOR PREDICTING THERAPEUTIC EFFICACY OF KINASE INHIBITORS IN PATIENTS WITH MYELODYSPLASTIC SYNDROME OR RELATED DISORDERS
    Publication number: 20160102363
    Abstract: The invention discloses a diagnostic method for predicting the therapeutic efficacy of a broad specificity kinase inhibitor in a subject with refractory cancer comprising determining the locus-specific DNA methylation profile of the subject, wherein the locus-specific DNA methylation profile predicts the therapeutic efficacy of a broad specificity kinase inhibitor for treatment of a subject with refractory cancer.
    Type: Application
    Filed: May 28, 2014
    Publication date: April 14, 2016
    Applicants: ONCONOVA THERAPEUTICS, INC., THE TRUSTEES OF COLUMBIA UNVIERSITY IN THE CITY OF NEW YORK
    Inventors: BENJAMIN TYCKO, AZRA RAZA, FRANCOIS WILHELM
  • METHODS AND COMPOSTIONS FOR TREATMENT OF CANCER
    Publication number: 20150313859
    Abstract: The invention discloses a method of treating cancer refractory to an anticancer agent comprising administering to a cancer patient a pharmaceutical composition comprising at least one compound of Formula 1 Where R1 is selected from the group consisting of —NH2, —NH—CH2—COOH, —NH—CH(CH3)—COOH, —NH—C(CH3)2—COOH, —NH—CH2—CH2—OH and —N—(CH2CH2OH)2 or a pharmaceutically acceptable salt of such a compound, and an anticancer agent.
    Type: Application
    Filed: December 6, 2013
    Publication date: November 5, 2015
    Applicants: ONCONOVA THERAPEUTICS, INC., THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: MANOJ MANIAR, AZRA RAZA, FRANCOIS WILHELM