Patents by Inventor Francoise Baleux

Francoise Baleux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10138280
    Abstract: The invention relates to polypeptides, defined through a consensus sequence, having a length from 10 to 80 amino-acid residues, and whose polypeptidic sequence comprises or consists of the consensus sequence P1(Xa)P3(Xb)P5(Xc)P6(Xd)P7 (SEQ ID NO: 1), presenting specific patterns. The polypeptides of the invention target glycosylated Muc2 proteins. The invention also relates to methods of synthesis of such polypeptides, to their nucleic acids and uses thereof. The polypeptidic sequence of the polypeptides of the invention can be part of the N-terminal sequence of a mucus-binding (MUB) domain, especially a mucus-binding (MUB) domain of several species. The invention also relates to chimeric molecule(s) comprising such polypeptides, which are labelled, and vectors, especially plasmids and population of cells or composition comprising polypeptides of the invention. Synthesis methods encompass biotechnological or chemical production.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: November 27, 2018
    Assignee: Institut Pasteur
    Inventors: Benoit Marteyn, Yves-Marie Coic, Francoise Baleux, Philippe Sansonetti
  • Patent number: 9907860
    Abstract: This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Said organic molecule comprises a 5 to 21 amino acid anionic polypeptide. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: March 6, 2018
    Assignees: INSTITUT PASTEUR, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE PARIS-SUD, UNIVERSITE GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Francoise Baleux, Hugues Lortat-Jacob, David Bonnaffe, Yves-Marie Coic
  • Publication number: 20170326246
    Abstract: This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Said organic molecule comprises a 5 to 21 amino acid anionic polypeptide. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
    Type: Application
    Filed: October 23, 2015
    Publication date: November 16, 2017
    Inventors: Francoise BALEUX, Hugues LORTAT-JACOB, David BONNAFFE, Yves-Marie COÏC
  • Publication number: 20160318981
    Abstract: The invention relates to polypeptides, defined through a consensus sequence, having a length from 10 to 80 amino-acid residues, and whose polypeptidic sequence comprises or consists of the consensus sequence P1(Xa)P3(Xb)P5(Xc)P6(Xd)P7 (SEQ ID NO: 1), presenting specific patterns. The polypeptides of the invention target glycosylated Muc2 proteins. The invention also relates to methods of synthesis of such polypeptides, to their nucleic acids and uses thereof. The polypeptidic sequence of the polypeptides of the invention can be part of the N-terminal sequence of a mucus-binding (MUB) domain, especially a mucus-binding (MUB) domain of several species. The invention also relates to chimeric molecule(s) comprising such polypeptides, which are labelled, and vectors, especially plasmids and population of cells or composition comprising polypeptides of the invention. Synthesis methods encompass biotechnological or chemical production.
    Type: Application
    Filed: June 9, 2016
    Publication date: November 3, 2016
    Applicant: INSTITUT PASTEUR
    Inventors: Benoit Marteyn, Yves-Marie Coic, Francoise Baleux, Philippe Sansonetti
  • Patent number: 9446109
    Abstract: A conjugate molecule comprising an oligo- or polysaccharide covalently bound to a carrier and its use as potential vaccine against infection by S. Flexneri.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: September 20, 2016
    Assignee: INSERM (Institut National De La Sante Et De La Recherche Medicale)
    Inventors: Armelle Phalipon, Farida Nato, Laurence Mulard, Philippe Sansonetti, Françoise Baleux, Frédéric Belot, Cyrille Grandjean
  • Patent number: 9382299
    Abstract: The invention relates to polypeptides, defined through a consensus sequence, having a length from 10 to 80 amino-acid residues, and whose polypeptidic sequence comprises or consists of the consensus sequence P1(Xa)P3(Xb)P5(Xc)P6(Xd)P7 (SEQ ID NO: 1), presenting specific patterns. The polypeptides of the invention target glycosylated Muc2 proteins. The invention also relates to methods of synthesis of such polypeptides, to their nucleic acids and uses thereof. The polypeptidic sequence of the polypeptides of the invention can be part of the N-terminal sequence of a mucus-binding (MUB) domain, especially a mucus-binding (MUB) domain of several species. The invention also relates to chimeric molecule(s) comprising such polypeptides, which are labelled, and vectors, especially plasmids and population of cells or composition comprising polypeptides of the invention. Synthesis methods encompass biotechnological or chemical production.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: July 5, 2016
    Assignee: Institut Pasteur
    Inventors: Benoit Marteyn, Yves-Marie Coic, Francoise Baleux, Philippe Sansonetti
  • Patent number: 9295730
    Abstract: This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
    Type: Grant
    Filed: January 27, 2009
    Date of Patent: March 29, 2016
    Assignees: Institut Pasteur, Commissariat A L'Energie Atomique Et Aux Eneergies Alternatives, Centre National De La Recherche Scientifique (CNRS)
    Inventors: Françoise Baleux, David Bonnaffe, Hugues Lortat-Jacob, Latino Loureiro-Morais
  • Patent number: 9078928
    Abstract: This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Said organic molecule comprises a 5 to 21 amino acid anionic polypeptide. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: July 14, 2015
    Assignee: Institut Pasteur
    Inventors: Françoise Baleux, Hugues Lortat-Jacob, David Bonnaffe
  • Publication number: 20140336119
    Abstract: The invention relates to polypeptides, defined through a consensus sequence, having a length from 10 to 80 amino-acid residues, and whose polypeptidic sequence comprises or consists of the consensus sequence P1(Xa)P3(Xb)P5(Xc)P6(Xd)P7 (SEQ ID NO: 1), presenting specific patterns. The polypeptides of the invention target glycosylated Muc2 proteins. The invention also relates to methods of synthesis of such polypeptides, to their nucleic acids and uses thereof. The polypeptidic sequence of the polypeptides of the invention can be part of the N-terminal sequence of a mucus-binding (MUB) domain, especially a mucus-binding (MUB) domain of several species. The invention also relates to chimeric molecule(s) comprising such polypeptides, which are labelled, and vectors, especially plasmids and population of cells or composition comprising polypeptides of the invention. Synthesis methods encompass biotechnological or chemical production.
    Type: Application
    Filed: September 7, 2012
    Publication date: November 13, 2014
    Applicant: INSTITUT PASTEUR
    Inventors: Benoit Marteyn, Yves-Marie Coic, Francoise Baleux, Philippe Sansonetti
  • Publication number: 20140161793
    Abstract: A conjugate molecule comprising an oligo- or polysaccharide covalently bound to a carrier and its use as potential vaccine against infection by S. Flexneri.
    Type: Application
    Filed: December 14, 2011
    Publication date: June 12, 2014
    Applicants: INSERM, INSTITUT PASTEUR, Centre National De La Recherche Scientifique
    Inventors: Armelle PHALIPON, Farida NATO, Laurence MULARD, Philippe SANSONETTI, Francoise BALEUX, Frederic BELOT, Cyrille GRANDJEAN
  • Publication number: 20140107043
    Abstract: This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Said organic molecule comprises a 5 to 21 amino acid anionic polypeptide. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
    Type: Application
    Filed: March 16, 2012
    Publication date: April 17, 2014
    Inventors: Françoise Baleux, Hugues Lortat-Jacob, David Bonnaffe
  • Publication number: 20130243751
    Abstract: A conjugate molecule comprising an oligo- or polysaccharide covalently bound to a carrier and its use as potential vaccine against infection by S. Flexneri.
    Type: Application
    Filed: December 14, 2011
    Publication date: September 19, 2013
    Inventors: Armelle PHALIPON, Farida Nato, Laurence Mulard, Philippe Sansonetti, Françoise Baleux, Frédéric Belot, Cyrille Grandjean
  • Patent number: 8124380
    Abstract: A conjugate molecule comprising an oligo- or polysaccharide covalently bound to a carrier and its use as potential vaccine against infection by S. Flexneri.
    Type: Grant
    Filed: July 2, 2004
    Date of Patent: February 28, 2012
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Institut Pasteur, Centre National de la Recherche Scientifique
    Inventors: Armelle Phalipon, Farida Nato, Laurence Mulard, Philippe Sansonetti, Françoise Baleux, Frédéric Belot, Cyrille Grandjean
  • Publication number: 20110105412
    Abstract: This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
    Type: Application
    Filed: January 27, 2009
    Publication date: May 5, 2011
    Inventors: Françoise Baleux, David Bonnaffe, Hugues Lortat-Jacob, Latino Loureiro-Morais
  • Publication number: 20110034383
    Abstract: Fragments of CXCL12 Gamma A chemokine having improved chemotaxis activity in vivo defined by an unprecedented capacity to associate and immobilise on extracellular glycans.
    Type: Application
    Filed: October 15, 2008
    Publication date: February 10, 2011
    Applicant: INSTITUT PASTEUR
    Inventors: Fernando Arenzana, Hugues Lortat-Jacob, Francoise Baleux
  • Publication number: 20110015368
    Abstract: The present invention relates to an activated peptide derived from the CD4 receptor, which is capable of coupling by covalent bonding to an organic molecule and thus makes it possible to generate multiple potentially antiviral derivatives. The present invention also relates to a conjugated molecule comprising the CD4-receptor-derived peptide and an organic molecule, preferably the GPR1 peptide or a polyanion. Such a conjugated molecule can in particular be used in antiviral treatments, in particular the treatment of AIDS. The invention also relates to the methods for preparing the activated peptide derived from the CD4 receptor and the conjugated molecule.
    Type: Application
    Filed: August 3, 2007
    Publication date: January 20, 2011
    Inventors: Françoise Baleux, David Bonnaffe, Hugues Lortat-Jacob
  • Patent number: 7820142
    Abstract: The invention relates to immunogenic glycopeptides derived from pathogenic microorganisms, which can be used for immunization and diagnosing infections dye to such pathogenic microorganisms and also to method for the selection and preparation thereof.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: October 26, 2010
    Assignee: Institut Pasteur
    Inventors: Gilles Marchal, Félix Romain, Pascale Pescher, Françoise Baleux, Daniel Scott-Algara, Laurence Mulard
  • Publication number: 20100240040
    Abstract: The invention relates to methods for screening for selective modulator of NF-?B pathway activation. The invention concerns methods for primary screening molecules that potentially modulate (activate or inhibit) the NF-?B pathway activation by identifying and selecting molecules modulate the interaction of NEMO with other proteins. The invention also concerns methods for secondary screening for modulator (activator or inhibitor) of the NF-?B pathway activation.
    Type: Application
    Filed: June 20, 2008
    Publication date: September 23, 2010
    Applicants: INSTITUT PASTEUR, Centre National De La Recherche Scient.
    Inventors: Fabrice Agou, Jeanne Chiaravalli, Yves-Marie Coic, Francoise Baleux, Alain Israel, Michel Veron
  • Patent number: 7700553
    Abstract: The present invention relates to polypeptides that inhibit the NF-&kgr;B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: April 20, 2010
    Assignees: Institut Pasteur, INSERM (Institut National de la Sante et de la Recherche Medicale), Centre National De La Recherche Scientifique
    Inventors: Fabrice Agou, Gilles Courtois, Alain Israel, Michel Veron, Francois Traincard, Shoji Yamaoka, Yves-Marie Coic, Francoise Baleux
  • Publication number: 20080293620
    Abstract: A method for diagnosing an infection in a patient likely to be infected with a pathogenic microorganism, comprising the detection of CD4+ T lymphocytes recognizing at least one glycopeptide derived from said pathogenic microorganism, essentially consisting of a glycosylated T epitope, comprising from 14 to 25 amino acids, among which at least one neutral amino acid is bonded to a disaccharide or to a trisaccharide, and at least 15% of said amino acids are prolines, one of the prolines being located in position ?1 to ?4, relative to the position of said neutral amino acid.
    Type: Application
    Filed: September 29, 2005
    Publication date: November 27, 2008
    Applicant: Institut Pasteur
    Inventors: Gilles Marchal, Felix Romain, Pascale Pescher, Francoise Baleux, Daniel Scott-Algara, Laurence Mulard