Patents by Inventor Francoise Barre-Sinoussi

Francoise Barre-Sinoussi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the preparation of hybridomas producing lymphadenopathy-associated virus (LAV) GP110-specific monoclonal antibodies and methods for the purification of GP110 employing said monoclonal antibodies
    Patent number: 5610035
    Abstract: A novel human retrovirus which is the aetiological agent of acquired immune deficiency syndrome (AIDS), designated lymphadenopathy-associated virus (LAV), was isolated from the lymph nodes of a patient suffering from generalized persistant lymphadenopathy. LAV displays a tropism for CD4.sup.+ lymphocytes, a Mg.sup.2+ -dependent reverse transcriptase (RT) activity, a density of 1.16-1.17 as determined by sucrose gradient centrifugation, a particle diameter of 139 nm, and a p25 antigen that is immunologically distinct from the HTLV-I/II p24 protein. Radioimmunoprecipitation analysis (RIPA) of .sup.35 S-cysteine-labeled viral or cellular lysates employing patient antisera resulted in the identification of a viral antigen having a molecular weight of 110 kDa. Endoglycosidase treatment of this antigen produces a protein with a molecular weight of 90 kDa. Methods are disclosed for the preparation of hybridomas producing LAV gp110-specific monoclonal antibodies (Mabs).
    Type: Grant
    Filed: September 27, 1994
    Date of Patent: March 11, 1997
    Assignee: Institut Pasteur Centre National de la Recherche Scientific
    Inventors: Luc Montagnier, Bernard Krust, Solange Chamaret, Francois Clavel, Jean-Claude Chermann, Francoise Barre-Sinoussi
  • Monoclonal antibodies to GP110 of HIV and hybridomas secreting these antibodies
    Patent number: 5407811
    Abstract: This invention is directed to an isolated antibody specific for gp110 glycoprotein of a human immunodeficiency virus type 1 (HIV-1), and a hybridoma which produces such an antibody. HIV-1 is the causative agent of Acquired Immunodeficiency Syndrome (AIDS).
    Type: Grant
    Filed: September 24, 1992
    Date of Patent: April 18, 1995
    Assignee: Institut Pasteur and Centre National de la Recherche Scientific
    Inventors: Luc Montagnier, Bernard Krust, Solange Chamaret, Francois Clavel, Jean-Claude Chermann, Francoise Barre-Sinoussi
  • Glucosyl phosphotriesters of thymidine
    Patent number: 5393744
    Abstract: A compound having the following formula I: ##STR1## in which: R' represents a hydrogen atom or an azido group,alc represents an alkyl group of 1 to 4 carbon atoms, an alkoxy group of 1 to 4 carbon atoms or an amino group.
    Type: Grant
    Filed: January 29, 1990
    Date of Patent: February 28, 1995
    Assignee: Institut Pasteur
    Inventors: Tam Huynh Dinh, Catherine Gouyette, Bernadette Dupraz, Jean Igolen, Nathalie Savatier, Jean-Francois Nicolas, Francoise Barre-Sinoussi
  • Oligopeptides comprising p18 protein of human immunodeficiency virus (HIV), compositions comprising peptides of p18 protein of HIV, and diagnostic kits and methods for detecting acquired immune deficiency syndrome (AIDS)
    Patent number: 5374519
    Abstract: Protein compositions containing the p18 and p25 proteins of the lymphadenopathy virus are used for detecting antibodies in blood serum as indicative of infection by such virus. The proteins can be used in various conventional ways to perform immunoassays for the detection of the antibodies.
    Type: Grant
    Filed: September 28, 1992
    Date of Patent: December 20, 1994
    Assignee: Institut Pasteur
    Inventors: Luc Montagnier, Jean-Claude Chermann, Francoise Barre-Sinoussi, Francoise Vezinet-Brun, Christine Rouzioux, Willy Rozenbaum, Charles Dauguet, Jacqueline Gruest, Marie-Theresa Nugeyre, Francoise Rey, Claudine Axler-Blin, Solange Chamaret
  • Antigen of a human retrovirus, namely p18 protein of human immunodeficiency virus (HIV), compositions containing the antigen, a diagnostic method for detecting acquired immune deficiency syndrome (AIDS) and pre-AIDS and a kit therefor
    Patent number: 5217861
    Abstract: Protein compositions containing proteins of the lymphadenopathy virus, which compositions are used for diagnosis of antibodies of such protein in biological fluids, especially blood serum, for the detection or absence of infection. Such compositions contain typically the p18, p13 and/or p25 proteins.
    Type: Grant
    Filed: February 12, 1988
    Date of Patent: June 8, 1993
    Assignee: Institut Pasteur
    Inventors: Luc Montagnier, Jean-Claude Chermann, Francoise Barre-Sinoussi, Francoise Vezinet-Brun, Christine Rouzioux, Willy Rozenbaum, Charles Dauguet, Jacqueline Gruest, Marie-Theresa Nugeyre, Francoise Rey, Claudine Axler-Blin, Solange Chamaret
  • Antibody detection of antibodies to viral proteins in serum
    Patent number: 5173400
    Abstract: Protein compositions containing the p18 and p25 proteins of the lymphadenopathy virus are used for detecting antibodies in blood serum as indicative of infection by such virus. The proteins can be used in various conventional ways to perform immunoassays for the detection of the antibodies.
    Type: Grant
    Filed: October 22, 1991
    Date of Patent: December 22, 1992
    Assignee: Institut Pasteur
    Inventors: Luc Montagnier, Jean C. Chermann, Francoise Barre-Sinoussi, Francoise Vezinet-Brun, Christine Rouzioux, Willy Rozenbaum, Charles Dauguet, Jacqueline Gruest, Marie Theresa Nugeyre, Francoise Rey, Claudine Axler-Blin, Solange Chamaret
  • Human Immunodeficiency Virus (HIV) associated with Acquired Immunual Deficiency Syndrome (AIDS), a diagnostic method for aids and pre-aids, and a kit therefor
    Patent number: 5135864
    Abstract: Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS), including Lymphadenopathy Associated Virus (LAV), are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. LAV is a Human Immunodeficiency Virus (HIV). Viral extract, structural proteins and other fractions of the retrovirus immunologically recognize the sera of such patients. Immunological reaction is used to detect antibodies that specifically bind to antigenic sites of the retrovirus in samples of body fluids from patients with AIDS or risk of AIDS. A kit for in vitro assay of LAS or AIDS is provided.
    Type: Grant
    Filed: November 5, 1987
    Date of Patent: August 4, 1992
    Assignees: Institut Pasteur, The United States of America as represented by the Secretary of The Department of Health and Human Services
    Inventors: Luc Montagnier, Jean-Claude Chermann, Francoise Barre-Sinoussi, Francoise Brun-Vezinet, Christine Rouzioux, Willy Rozenbaum, Charles Dauguet, Jacqueline Gruest, Marie-Therese Nugeyre, Francoise Rey, Claudine Axler-Blin, Solange Chamaret, Robert C. Gallo, Mikulas Popovic, Mangalasseril G. Sarngadharan
  • Viral strain isolated from cerebrospinal fluid of an HIV seropositive man having acute and regressive encephalopathy and use of the strain in an immunoassay
    Patent number: 4956292
    Abstract: A new viral strain from the cerebrospinal fluid of an HIV seropositive man is identified. The new strain, products derived from the new strain, a diagnostic method for detecting antibodies to the new strain in biological fluids, and a diagnostic kit for carrying out the method are described.
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: September 11, 1990
    Assignee: Institut Pasteur
    Inventors: Jean-Claude Chermann, Blandine Rouquette, Francoise Rey, Francoise Barre-Sinoussi
  • Novel treatment
    Patent number: 4759929
    Abstract: A novel method of treating acquired immune deficiency syndromes in warm-blooded animals comprising administering to warm-blooded animals an amount of a non-toxic, pharmaceutically acceptable salt selected from the group consisting of alkali metal, alkaline earth metal and ammonium salts of 9-antimonio-III-21-tungsto-VI-sodate -III-21-tungsto-VI-sodate sufficient to combat acquired immune deficiency syndromes.
    Type: Grant
    Filed: February 5, 1987
    Date of Patent: July 26, 1988
    Assignee: Cabinet Harle & Phelip
    Inventors: Jean-Claude Chermann, Dominique Dormont, Etienne Vilmer, Bruno Spire, Francoise Barre-Sinoussi, Luc Montagnier, Willy Rozenbaum
  • Human immunodeficiency viruses associated with Acquired Immune Deficiency Syndrome (AIDS), a diagnostic method for AIDS and pre-AIDS, and a kit therefor
    Patent number: 4708818
    Abstract: Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS), including Lymphadenopathy Associated Virus (LAV), are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. LAV is a Human Immunodeficiency Virus (HIV). Viral extract, structural proteins and other fractions of the retrovirus immunologically recognize the sera of such patients. Immunological reaction is used to detect antibodies that specifically bind to antigenic sites of the retrovirus in samples of body fluids from patients with AIDS or risk of AIDS. A kit for in vitro assay of LAS or AIDS is provided.
    Type: Grant
    Filed: October 8, 1985
    Date of Patent: November 24, 1987
    Assignees: Institut Pasteur, The United States of America as represented by the Department of Health and Human Services
    Inventors: Luc Montagnier, Jean-Claude Chermann, Francoise Barre-Sinoussi, Francoise Brun-Vezinet, Christine Rouzioux, Willy Rozenbaum, Charles Dauguet, Jacqueline Gruest, Marie-Therese Nugeyre, Francoise Rey, Claudine Axler-Blin, Solange Chamaret, Robert C. Gallo, Mikulas Popovic, Mangalasseril G. Sarngadharan