Abstract: Disclosed are compounds having structural formulas (I)-(XI), and related pharmaceutical compositions. Also disclosed are methods of selecting and treating human subjects suffering from a kidney disease, using the compounds of formulas (I)-(XI), and methods of determining the efficacy of TRPC5 inhibitor therapies using the same.

Abstract: According to a first aspect, the invention relates to an optical security component intended to be observed in reflection, with the naked eye, according to face of observation. It comprises a first layer made of dielectric material, having a first refractive index (n1), at least one first diffractive structure (S1, S2) etched on said first layer. The first diffractive structure comprises a first pattern with at least one set of modules disposed side-by-side, in a given direction (X) of arrangement, a maximum width (l) of each module defined in the direction of arrangement (X) being less than 300 ?m. Each module comprises a bas-relief with a first set of facets whose forms are determined to simulate an optical element visible in reflection, with at least one convex or concave region, said optical element having a profile with a continuously variable slope in a single direction (Y), said direction of variation of the slope, at right angles to the direction of arrangement (X).

Abstract: According to a first aspect, the invention relates to an optical security component intended to be observed in reflection, with the naked eye, according to face of observation. It comprises a first layer made of dielectric material, having a first refractive index (n1), at least one first diffractive structure (S1, S2) etched on said first layer. The first diffractive structure comprises a first pattern with at least one set of modules disposed side-by-side, in a given direction (X) of arrangement, a maximum width (l) of each module defined in the direction of arrangement (X) being less than 300 ?m. Each module comprises a bas-relief with a first set of facets whose forms are determined to simulate an optical element visible in reflection, with at least one convex or concave region, said optical element having a profile with a continuously variable slope in a single direction (Y), said direction of variation of the slope, at right angles to the direction of arrangement (X).

Abstract: A secure product, and a production method, comprising a first reflective layer, a second layer and a third layer including readable information, the first layer being enclosed between the second and the third layers, in which the first and second layers are transparent, at least a first part of the internal surface of the second layer comprises a diffusing microstructure, and the diffusing microstructure is positioned so as to cover a predetermined part of the readable information.

Abstract: A secure product, and a production method, comprising a first reflective layer, a second layer and a third layer including readable information, the first layer being enclosed between the second and the third layers, in which the first and second layers are transparent, at least a first part of the internal surface of the second layer comprises a diffusing microstructure, and the diffusing microstructure is positioned so as to cover a predetermined part of the readable information.

Abstract: A method for securing a document (1), and a secure document (1) including a data medium (2) and an optical security component (3). The medium (2) includes a first surface (12) and a second surface (13). The optical component (3) includes an element (21) for generating optical effects and an adhesive element (5) adhering to the first surface (21) of the medium (2). Customization data (16,17,18,19,20) are written on the secure document (1). The secure document (1) also includes an additional sealing component (4) including adhesive element (10) adhering to the second surface (13) of the medium (2), the medium (2) including at least one perforation (14, 15) arranged so that the optical (3) and additional (4) components are bonded to each other through the perforation (14, 15).

Abstract: A method of preparing an optical security component having a metallic appearance and having a diffraction grating. The method includes the following steps: preparing a transparent polyester film; depositing a stamping layer, into which the hologram producer has pressed the appropriate microstructures; stamping; vacuum depositing a fine layer of a dielectric material having a high optical index; coating or printing at least one layer of translucent coloured varnish; and vacuum depositing a layer of aluminium. An optical security component thus produced is also disclosed.

Abstract: Methods and adhesive labels useful in marking products or documents by applying these to substrates. A mark such as a barcode, photograph or characters are formed directly on the substrate and the adhesive label is applied over it. The adhesive label includes a concealing film layer which is transparent to a first wavelength outside the visible region, a diffractive optical mark with a transparent reflective layer and an adhesive layer. The first wavelength may be infrared allowing the underlying mark to be read by an IR laser. The adhesive labels are formed as to allow them to be continuously separated from a temporary detachment layer, thereby exposing the adhesive layer, and affixed to the document.

Abstract: A method for marking articles or documents by placing on a substrate (1) a multi-layer optical complex consisting of an identifying portion (2, 7) such as bar codes, a photograph or characters, and an authenticating portion consisting of a diffracting optical mark, said portions being arranged one on top of the other in such a way that they cannot be separated without destroying the authenticating portion. A protected document is also disclosed which comprises an indivisible stack consisting of a printed portion (2, 7) forming an identifier read by reflection in a first wavelength band, and coated with a lacquer (5) that is opaque in the visible spectrum and has a transmission window including said first wavelength band, as well as a transparent reflective layer (4) forming a diffracting optical mark. A marking system for carrying out the method, and a device for checking said article or document, are also disclosed.