Abstract: N-Cyano-azomethines, useful as intermediates for the production of antihistamines are described. They are produced by reaction of ##STR1## where R.sub.3 is a thiomethyl group, an alkylamino group or N-1-amino-.omega.-alkylthiomethyl group, with primary or secondary alkyl- or hydroxyalkyl-amines or with ethylenimine.

Abstract: A method for preparing N(1)-alkylated-5-phenyl-7-substituted deoxy-1,4-benzodiazepines utilizing a polyphosphoric acid alkyl ester of the formula: ##STR1## wherein R.sub.3 is an alkyl radical with up to 4 carbon atoms as the alkylating agent, is described.

Abstract: A process for preparing 5-nitroimidazole compounds of ##STR1## where R and R.sub.1 are each alkyl from 1 to 4 carbon atoms, A is oxygen and n is 1, allowing for improved yields of the final products, is described.

Abstract: A method for the biosynthesis of a microbial insecticide containing spores and crystalline endotoxin, in which a Bacillus thuringiensis microorganism is cultivated in a nutrient medium under formation of spores in such a way that the early lysis of the cells caused in the course of the submerged cultivation by the ventilation prior to the end of the formation of spores is prevented, is described.

Abstract: Optically active intermediates of the formula: ##STR1## in the S optical configuration wherein R.sub.1 is selected from the group consisting of hydrogen, halogen, nitro and trifluoromethyl, R.sub.2 is selected from the group consisting of hydrogen and C.sub.1-4 lower alkyl, and R.sub.3 is selected from the group consisting of C.sub.1-4 lower alkyl, hydroxy C.sub.1-4 lower alkyl, phenyl, hydroxyphenyl, benzyl, hydroxybenzyl, or 3'-methyleneindolyl, and A is a protective group, and their preparation is described. These compounds are useful in the preparation of corresponding optically active 1,4-benzodiazepines.

Abstract: Compositions, useful as tranquilizers containing, as active ingredient, an optically active compound having the formula: ##STR1## having an asymmetric carbon atom in position 3 having the S configuration and wherein R.sub.1 is selected from the group consisting of hydrogen, halogen, nitro, and trifluoromethyl groups, R.sub.2 is selected from the group consisting of hydrogen and C.sub.1-4 lower alkyl groups and R.sub.3 is selected from the group consisting of C.sub.1-4 lower alkyl, hydroxy C.sub.1-4 lower alkyl, phenyl, hydroxyphenyl, benzyl, hydroxybenzyl, and 3'-methyleneindolyl groups, is described.They are obtained by reaction of a compound having the formula ##STR2## with a compound of the formula wherein A is a protective group.The compounds of formula I have sedative and tranquilizing properties.

Abstract: A process is disclosed for preparing optically active 1,4-diazepine-2-ones by reacting an acid chloride-hydrochloride of an optically active .alpha.-amino acid with a substituted o-amino benzophenone, to form an intermediate product and subsequently cyclizing the intermediate product to form the desired 1,4-diazepine-2-one. The process is carried out in inert organic or aqueous-organic solvents. The process eliminates the need for using .alpha.-amino acids having bound to the amino group a protective group which must be removed before cyclization.

Abstract: Optically active compounds having the formula ##STR1## having an asymmetric carbon atom in position 3 having the S configuration and wherein R.sub.1 is selected from the class consisting of hydrogen, halogen, nitro, and trifluoromethyl groups, R.sub.2 is selected from the group consisting of hydrogen and C.sub.1-4 lower alkyl groups and R.sub.3 is selected from the group consisting of C.sub.1-4 lower alkyl, hydroxy C.sub.1-4 lower alkyl, phenyl, hydroxy phenyl, benzyl, hydroxy benzyl, and 3'-methyleneindolyl groups.They are obtained by reaction of a compound having the formula ##STR2## with a compound of the formula wherein A is a protective group.The compounds of formula I have sedative and tranquilizing properties.

Abstract: A process for the production of piperazine derivatives including the formation of compounds having the general formula ##STR1## wherein Y is a halogen atom, SO.sub.3 H.sup.-, SO.sub.4.sup.-.sup.- or another anion. The compounds exhibit cytostatic, cancer retardant and tranquilizing properties.