Patents by Inventor Frank A. Blocki

Frank A. Blocki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker
    Patent number: 10983136
    Abstract: The present invention relates to the use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker. More particularly, the present invention relates to a method for predicting or stratifying the risk of worsening renal function (WRF) in a patient at risk of renal injury or affected by renal injury. Levels of 1,25-dihydroxyvitamin D (1,25(OH)2D) are measured in a biological sample and taken together with parathyroid hormone (PTH) levels to provide a ratio indicative of the risk of worsening renal function.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: April 20, 2021
    Assignee: DiaSorin S.p.A.
    Inventors: Francesco Colotta, Fabrizio Bonelli, Frank Blocki, Claudia Zierold, Joshua Soldo, Gregory Olson, Michael Lutterman, John Wall, Michael New, Hector Floyd Deluca
  • Use of 1,25-Dihydroxyvitamin D Values in Ratio with PTH as a Prognostic Biomarker
    Publication number: 20210072264
    Abstract: The present invention relates to the use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker. More particularly, the present invention relates to a method for predicting or stratifying the risk of worsening renal function (WRF) in a patient at risk of renal injury or affected by renal injury. Levels of 1,25-dihydroxyvitamin D (1,25(OH)2D) are measured in a biological sample and taken together with parathyroid hormone (PTH) levels to provide a ratio indicative of the risk of worsening renal function.
    Type: Application
    Filed: November 23, 2020
    Publication date: March 11, 2021
    Applicant: DiaSorin S.p.A.
    Inventors: Francesco Colotta, Fabrizio Bonelli, Frank Blocki, Claudia Zierold
  • Use of 1,25-Dihydroxyvitamin D Values in Ratio with PTH as a Prognostic Biomarker
    Publication number: 20170322230
    Abstract: The present invention relates to the use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker. More particularly, the present invention relates to a method for predicting or stratifying the risk of worsening renal function (WRF) in a patient at risk of renal injury or affected by renal injury. Levels of 1,25-dihydroxyvitamin D (1,25(OH)2D) are measured in a biological sample and taken together with parathyroid hormone (PTH) levels to provide a ratio indicative of the risk of worsening renal function.
    Type: Application
    Filed: July 17, 2017
    Publication date: November 9, 2017
    Applicant: DiaSorin S.p.A.
    Inventors: Francesco Colotta, Fabrizio Bonelli, Frank Blocki, Claudia Zierold
  • Luminescent analyses with enhanced storage stability
    Patent number: 4835101
    Abstract: The storage stability of peroxidase-reactive luminescent cocktails which employ chemiluminescent 2,3-dihydro-1,4-phthalazinediones, oxidants reactant therewith to cause light emission in peroxidase-mediated luminescent reactions, and phenolic sensitivity enhancers is improved by maintaining the pH of the cocktail prior to use at a value in the range of about 3 to about 6 and preferably at a pH of about 5. An analyte sample may be subjected to a reaction resulting in a peroxidase-containing phase, the peroxidase content of which is related to the quantity of analyte in the sample, and the peroxidase phase may then be combined with the thus-described cocktail and an aqueous alkaline organic buffer to raise the pH of the resulting reaction mixture to a value in the range of 7-9, favoring light emission.
    Type: Grant
    Filed: October 27, 1986
    Date of Patent: May 30, 1989
    Assignee: Kallestad Diagnostics, Inc.
    Inventors: Richard Kao, Frank A. Blocki, Robert A. Pranis, Walter C. Mahoney