Abstract: The invention relates to imidazopyridines of Formula (I) and pharmaceutically acceptable salts thereof, wherein R0 to R5 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

Abstract: A thermal storage system includes a container, a thermal exchange device, a first thermal storage material, and a second thermal storage material. The first thermal exchange device is disposed in the container. The first thermal storage material is disposed in the container and is spaced apart from the thermal exchange device. The second thermal storage material is also disposed in the container in contact with the thermal exchange device. The first and second thermal storage materials are immiscible. The second thermal storage material is less reactive with the construction material of the thermal exchange device as compared to the first thermal storage material. Optionally, a second thermal exchange device can be submerged in the second thermal storage material. The first thermal exchange device is configured to supply heat to the second thermal storage material and the second thermal exchange device facilitates extraction of heat from the second thermal storage material.

Abstract: Disclosed are various embodiments for virtual desktop infrastructure optimization. A computing device can create a plurality of predictions for future demand for the VDI, each of the plurality of predictions using a respective one of a plurality of resource models, each representing a separate approach to predict future demand for the VDI. Then, the computing device can calculate a plurality of anticipated resource costs, each of the plurality of anticipated resource costs being based at least in part on a respective one of the plurality of predictions for future demand for the VDI. Moreover, the computing device can include, within a user interface, the plurality of predictions for future demand and the plurality of anticipated resource costs. Then, the computing device can implement a resource model from the plurality of resource models to manage an allocation of resources for the VDI in response to a selection of the resource model through the user interface.

Abstract: A thermal storage system includes a container, a thermal exchange device, a first thermal storage material, and a second thermal storage material. The first thermal exchange device is disposed in the container. The first thermal storage material is disposed in the container and is spaced apart from the thermal exchange device. The second thermal storage material is also disposed in the container in contact with the thermal exchange device. The first and second thermal storage materials are immiscible. The second thermal storage material is less reactive with the construction material of the thermal exchange device as compared to the first thermal storage material. Optionally, a second thermal exchange device can be submerged in the second thermal storage material. The first thermal exchange device is configured to supply heat to the second thermal storage material and the second thermal exchange device facilitates extraction of heat from the second thermal storage material.

Abstract: A thermal storage system includes a container, a thermal exchange device, a first thermal storage material, and a second thermal storage material. The first thermal exchange device is disposed in the container. The first thermal storage material is disposed in the container and is spaced apart from the thermal exchange device. The second thermal storage material is also disposed in the container in contact with the thermal exchange device. The first and second thermal storage materials are immiscible. The second thermal storage material is less reactive with the construction material of the thermal exchange device as compared to the first thermal storage material. Optionally, a second thermal exchange device can be submerged in the second thermal storage material. The first thermal exchange device is configured to supply heat to the second thermal storage material and the second thermal exchange device facilitates extraction of heat from the second thermal storage material.

Abstract: A novel portable solar energy system includes a solar concentrator, a thermal storage device, an azimuth adjustment system, an elevation system, and a heat exchanger, all mounted on a rotatable support frame. In a particular embodiment, the thermal storage device remains at a fixed vertical height and fixed tilt orientation when adjustments are made to the azimuth adjustment system and/or the elevation adjustment system.

Abstract: A novel portable solar energy system includes a solar concentrator, a thermal storage device, an azimuth adjustment system, an elevation system, and a heat exchanger, all mounted on a rotatable support frame. In a particular embodiment, the thermal storage device remains at a fixed vertical height and fixed tilt orientation when adjustments are made to the azimuth adjustment system and/or the elevation adjustment system.

Abstract: A contractor knee pad designed for long-term comfort when working kneeling on the ground or on the floor. The kneeling work pads of the invention have a hard inner core and a comfortable outer sheath which protects the contractors knee from the inner core, a wide elastic webbing may be stretched across the back of the wearer's leg from one side of the kneeling work pads to the other. In order to provide uniform tension, a zipper is employed, the zipper of the wide elastic webbing closes downward, that is, the opposite to the most common direction. Optional strips attach to strip anchors actually on the front of the contractors kneeling word pads, which are simple studs so that the strips may be put over the stud to be held in place and no part of the attachment reaches to the back of the device.

Abstract: A novel portable solar energy system includes a solar concentrator, a thermal storage device, an azimuth adjustment system, an elevation system, and a heat exchanger, all mounted on a rotatable support frame. In a particular embodiment, the thermal storage device remains at a fixed vertical height and fixed tilt orientation when adjustments are made to the azimuth adjustment system and/or the elevation adjustment system.

Abstract: The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K.

Abstract: A device implementing an adaptive positioning system may include at least one processor that is configured to concurrently implement a first positioning system that generates first positioning information items and a second positioning system that generates second positioning information items. The processor may be configured to buffer the second positioning information items generated by the second positioning system and to determine a position estimation for the device based on the first positioning information items generated by the first positioning system. The processor may be configured to detect a degradation in a quality of the first positioning system. The processor may be configured to, in response to detecting the degradation in the quality of the first positioning system, determine the position estimation for the device based at least in part on at least one of the buffered second positioning information items generated by the second positioning system.

Abstract: A novel portable solar energy system includes a solar concentrator, a thermal storage device, an azimuth adjustment system, an elevation system, and a heat exchanger, all mounted on a rotatable support frame. In a particular embodiment, the thermal storage device remains at a fixed vertical height and fixed tilt orientation when adjustments are made to the azimuth adjustment system and/or the elevation adjustment system.

Abstract: A contractor knee pad designed for long-term comfort when working kneeling on the ground or on the floor. The kneeling work pads of the invention have a hard inner core and a comfortable outer sheath which protects the contractors knee from the inner core, a wide elastic webbing may be stretched across the back of the wearer's leg from one side of the kneeling work pads to the other. In order to provide uniform tension, a zipper is employed, the zipper of the wide elastic webbing closes downward, that is, the opposite to the most common direction. Optional strips attach to strip anchors actually on the front of the contractors kneeling word pads, which are simple studs so that the strips may be put over the stud to be held in place and no part of the attachment reaches to the back of the device.

Abstract: A contractor knee pad designed for long-term comfort when working kneeling on the ground or on the floor. The kneeling work pads of the invention have a hard inner core and a comfortable outer sheath which protects the contractors knee from the inner core, a wide elastic webbing may be stretched across the back of the wearer's leg from one side of the kneeling work pads to the other. In order to provide uniform tension, a zipper is employed, the zipper of the wide elastic webbing closes downward, that is, the opposite to the most common direction. Optional strips attach to strip anchors actually on the front of the contractors kneeling word pads, which are simple studs so that the strips may be put over the stud to be held in place and no part of the attachment reaches to the back of the device.

Abstract: Unlike conventional through-air drying processes the instant invention utilizes at least two through-air driers where the first dyer is at least partially encircled by a first through-air drying fabric and the second dyer is at least partially encircled by a second through-air drying fabric. By providing each through-air dryer with its own fabric the overall drying performance may be increased. Additionally, in certain embodiments, the first and second fabrics may be different to optimize both the drying performance and/or tissue product properties.

Abstract: The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K.

Abstract: Unlike conventional through-air drying processes the instant invention utilizes at least two through-air driers where the first dyer is at least partially encircled by a first through-air drying fabric and the second dyer is at least partially encircled by a second through-air drying fabric. By providing each through-air dryer with its own fabric the overall drying performance may be increased. Additionally, in certain embodiments, the first and second fabrics may be different to optimize both the drying performance and/or tissue product properties.

Abstract: Methods, systems, and techniques for federating operations, in an optimized way using wide area networks are provided. Example systems provide an API for generating and handling federated requests as an aggregation. In one example Wide Area Network Aggregation System, WANAS provides an API, a connection manager, and connection iterators to manage inter-site connections and requests, and inter-pod requests and messaging. These components cooperate to distribute a task across multiple physically disparate sites using a representative connection to the site and fan out of requests to other pods within the site.

Abstract: Creped tissue webs having low surface-roughness and high sheet bulk are disclosed. Specifically creped, single ply tissue web having a single wire probe mean deviation of MIU (MMD) of less than about 0.040 and a sheet bulk of greater than about 12 cc/g are disclosed. Additionally creped, multi-ply tissue web having a single wire probe mean deviation of MUI (MMD) of less than about 0.035 and a sheet bulk of greater than about 10 cc/g are disclosed.

Abstract: The present invention provides a perforating station comprising two or more discrete perforating stations, the stations synchronized with one another to cut a line of perforations across a web, such as a web of tissue paper, moving at high speeds. By providing two or more synchronized perforating stations the perforating station may increase the number of impacts per minute compared to prior art perforating devices.