Abstract: This invention relates to peptides and their use for modulating sodium channels. More particularly, the present invention relates to peptides and their use in methods of enhancing Nav1.1 activity and for treating or preventing conditions associated with Nav1.1 activity.

Abstract: This invention relates to peptides and their use for modulating sodium channels. More particularly, the present invention relates to peptides and their use in methods of enhancing Nav1.1 activity and for treating or preventing conditions associated with Nav1.1 activity.

Abstract: The present invention provides assays utilizing SPR to detect protein-ligand interactions as well as compositions utilized is such assays.

Abstract: The present invention provides the use of compounds which selectively block the Nav1.1 subtype of voltage-gated sodium (Nav) channels, whose role in nociception and pain has been unexplored. The present invention demonstrates that Nav1.1-expressing fibers are modality specific nociceptors: their activation elicits robust pain behaviors without neurogenic inflammation and produces profound hypersensitivity to mechanical, but not thermal, stimuli. In the gut, high-threshold mechanosensitive fibers also express Nav1.1 and show enhanced toxin sensitivity in a model of irritable bowel syndrome. The present invention provides an unexpected role for Nav1.1 in regulating the excitability of sensory nerve fibers that underlie mechanical pain, and provides methods of screening for other peptides and small molecules that can modulate Nav1.1 channels and their use in treatment of neurological disorders.

Abstract: The present invention provides compounds of formula I or a salt, solvate, or stereoisomer thereof, wherein X is H, or an electron withdrawing group such as a halogen, NH2, NO2, SO2, CN, or a C1-C6 alkyl group; Alk is C1-C3 alkyl; R1 is H, C1-C6 alkyl, which may be substituted with OH, NH2, acyl, sulfonyl, and cyano groups; and R2, is C1-C6 alkyl, which may be substituted with OH, NH2, acyl, sulfonyl, and cyano groups. Pharmaceutical compositions comprising these compounds and/or rufinamide are also provided. Methods for prevention and treatment of epilepsy disorders such as Lennox-Gastaut Syndrome (LGS), and modulation of voltage-gated sodium (Nav) channels are Nav1.1 channels by administration of these compounds and/or rufinamide are also provided.

Abstract: The present invention provides polypeptides and their variants and derivatives which modulate GABAA receptor function at nanomolar quantities by binding to the ?+/?? subunit interface, as well as methods of making and using the same. The inventive peptides are useful for the study of neurological disease and function and can have therapeutic applications.

Abstract: The present invention provides assays utilizing SPR to detect protein-ligand interactions as well as compositions utilized is such assays.

Abstract: The present invention provides compounds of formula I which are capable of inhibition of the activation of hNav1.1 or hNav1.6 sodium channels in neurons. Pharmaceutical compositions comprising these compounds are also provided. Methods for prevention and treatment of neurological disorders, including, for example, seizures and seizure disorders, including Lennox-Gastaut Syndrome, Dravet syndrome, epileptic encephalopathies, autism, Familial hemiplegic migraine (FHM), anxiety disorders, including Post-traumatic stress disorder (PTSD), panic disorder and obsessive-compulsive disorder, neuropathic pain, and Rett syndrome by administration of these compounds are also provided.

Abstract: The present invention provides compounds of formula I which are capable of inhibition of the activation of hNav1.1 or hNav1.6 sodium channels in neurons. Pharmaceutical compositions comprising these compounds are also provided. Methods for prevention and treatment of neurological disorders, including, for example, seizures and seizure disorders, including Lennox-Gastaut Syndrome, Dravet syndrome, epileptic encephalopathies, autism, Familial hemiplegic migraine (FHM), anxiety disorders, including Post-traumatic stress disorder (PTSD), panic disorder and obsessive-compulsive disorder, neuropathic pain, and Rett syndrome by administration of these compounds are also provided.

Abstract: The present invention provides compounds of formula I which are capable of inhibition of the activation of hNav1.1 or hNav1.6 sodium channels in neurons. Pharmaceutical compositions comprising these compounds are also provided. Methods for prevention and treatment of neurological disorders, including, for example, seizures and seizure disorders, including Lennox-Gastaut Syndrome, Dravet syndrome, epileptic encephalopathies, autism, Familial hemiplegic migraine (FHM), anxiety disorders, including Post-traumatic stress disorder (PTSD), panic disorder and obsessive-compulsive disorder, neuropathic pain, and Rett syndrome by administration of these compounds are also provided.

Abstract: The present invention provides compounds of formula I or a salt, solvate, or stereoisomer thereof, wherein X is H, or an electron withdrawing group such as a halogen, NH2, NO2, SO2, CN, or a C1-C6 alkyl group; Alk is C1-C3 alkyl; R1 is H, C1-C6 alkyl, which may be substituted with OH, NH2, acyl, sulfonyl, and cyano groups; and R2, is C1-C6 alkyl, which may be substituted with OH, NH2, acyl, sulfonyl, and cyano groups. Pharmaceutical compositions comprising these compounds and/or rufinamide are also provided. Methods for prevention and treatment of epilepsy disorders such as Lennox-Gastaut Syndrome (LGS), and modulation of voltage-gated sodium (Nay) channels are Nav1.1 channels by administration of these compounds and/or rufinamide are also provided.

Abstract: The present invention provides compounds of formula I which are capable of inhibition of the activation of hNav1.1 or hNav1.6 sodium channels in neurons. Pharmaceutical compositions comprising these compounds are also provided. Methods for prevention and treatment of neurological disorders, including, for example, seizures and seizure disorders, including Lennox-Gastaut Syndrome, Dravet syndrome, epileptic encephalopathies, autism, Familial hemiplegic migraine (FHM), anxiety disorders, including Post-traumatic stress disorder (PTSD), panic disorder and obsessive-compulsive disorder, neuropathic pain, and Rett syndrome by administration of these compounds are also provided.

Abstract: An elastic fixing element and a coherent arrangement of such elements. These elastic fixing elements are intended in particular to hold together a first and a second element, rectilinear in particular, such as a vine shoot or a branch and a metal support wire. The elastic fixing element includes a closed loop, a head, and a neck connecting this head to the closed loop. This head is extended by a top stub. The closed loop is extended by a bottom stub, which facilitates the manual fitting of the elastic element around the elements to be secured. The coherent arrangement includes at least two elastic fixing elements. These elastic elements are connected together by a first link at the position of their respective top stubs. These elastic elements are connected together by a second link at the position of their respective bottom stubs.

Abstract: A device and a method for the automatic fitting of an elastic element, which includes a closed loop around a rectilinear element in particular, such as an assembly including a vine shoot and a support wire. The device includes an upper arm, equipped at one of its ends with a hook for hooking an upper portion of the closed loop of the elastic element, with the upper arm being mounted by its other end to pivot around an axis. The device also includes two lower arms, equipped at one of their ends with a hook for hooking a lower portion of the closed loop of the elastic element, with the lower arms being mounted by their other end to pivot around the same axis. The device also rotates around the axis of the upper arm in a given direction and of the lower arms in the reverse direction.

Abstract: A device and a method for the automatic fitting of an elastic element, which includes a closed loop around a rectilinear element in particular, such as an assembly including a vine shoot and a support wire. The device includes an upper arm, equipped at one of its ends with a hook for hooking an upper portion of the closed loop of the elastic element, with the upper arm being mounted by its other end to pivot around an axis. The device also includes two lower arms, equipped at one of their ends with a hook for hooking a lower portion of the closed loop of the elastic element, with the lower arms being mounted by their other end to pivot around the same axis. The device also rotates around the axis of the upper arm in a given direction and of the lower arms in the reverse direction.

Abstract: An elastic fixing element and a coherent arrangement of such elements. These elastic fixing elements are intended in particular to hold together a first and a second element, rectilinear in particular, such as a vine shoot or a branch and a metal support wire. The elastic fixing element includes a closed loop, a head, and a neck connecting this head to the closed loop. This head is extended by a top stub. The closed loop is extended by a bottom stub, which facilitates the manual fitting of the elastic element around the elements to be secured. The coherent arrangement includes at least two elastic fixing elements. These elastic elements are connected together by a first link at the position of their respective top stubs. These elastic elements are connected together by a second link at the position of their respective bottom stubs.