Patents by Inventor Frank Brichory

Frank Brichory has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Annexin proteins and autoantibodies as serum markers for cancer
    Patent number: 7955602
    Abstract: The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also provides screening methods for diagnosis and prognosis of cancer in a subject by means of detecting increased expression levels of annexin proteins in biological samples of the subject. The method of the invention can also be used to identify subjects at risk for developing cancer. The method of the invention involves the use of subject derived biological samples to determine the occurrence and level of expression of annexin proteins or expression of annexin derived peptides or antigens, and/or the occurrence and level of circulating autoantibodies to specific annexin protein antigens. The present invention further provides for kits for carrying out the above described screening methods.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: June 7, 2011
    Assignee: Regents of the University of Michigan
    Inventors: Samir M. Hanash, David Misek, Robert Hinderer, David Beer, Frank Brichory
  • Annexin proteins and autoantibodies as serum markers for cancer
    Publication number: 20040048320
    Abstract: The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also provides screening methods for diagnosis and prognosis of cancer in a subject by means of detecting increased expression levels of annexin proteins in biological samples of the subject. The method of the invention can also be used to identify subjects at risk for developing cancer. The method of the invention involves the use of subject derived biological samples to determine the occurrence and level of expression of annexin proteins or expression of annexin derived peptides or antigens, and/or the occurrence and level of circulating autoantibodies to specific annexin protein antigens. The present invention further provides for kits for carrying out the above described screening methods.
    Type: Application
    Filed: September 5, 2003
    Publication date: March 11, 2004
    Inventors: Samir M. Hanash, David Misek, Robert Hinderer, David Beer, Frank Brichory