Patents by Inventor Frank Bymaster

Frank Bymaster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240409514
    Abstract: The present invention relates to methods of inhibiting native and promiscuous uptake of biogenic amine neurotransmitters with triple reuptake inhibitors in the treatment of conditions affected by monoamine neurotransmitters.
    Type: Application
    Filed: June 7, 2024
    Publication date: December 12, 2024
    Applicant: Ethismos Research, Inc.
    Inventors: Anthony McKinney, Frank Bymaster
  • Patent number: 12042481
    Abstract: The present invention relates to (1R,5S)-(+)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane and pharmaceutical compositions thereof, and methods employing their use in the treatment of conditions affected by monoamine neurotransmitters, including ADHD and substance abuse.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: July 23, 2024
    Assignee: OTSUKA AMERICA PHARMACEUTICAL, INC.
    Inventors: Anthony Alexander McKinney, Frank Bymaster
  • Publication number: 20210267940
    Abstract: The present invention relates to (1R,5S)-(+)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane and pharmaceutical compositions thereof, and methods employing their use in the treatment of conditions affected by monoamine neurotransmitters, including ADHD and substance abuse.
    Type: Application
    Filed: March 12, 2021
    Publication date: September 2, 2021
    Inventors: Anthony Alexander McKinney, Frank Bymaster
  • Publication number: 20210161863
    Abstract: The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable active salts, polymorphs, glycosylated derivatives, metabolites, solvates, hydrates, and/or prodrugs of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and their use alone or in combination with additional psychotherapeutic compositions in the treatment of conditions affected by monoamine neurotransmitters, including treatment of refractory individuals.
    Type: Application
    Filed: September 30, 2020
    Publication date: June 3, 2021
    Inventors: Anthony Alexander McKinney, Frank Bymaster, Walter Piskorski
  • Publication number: 20210047268
    Abstract: The present invention relates to methods of inhibiting native and promiscuous uptake of biogenic amine neurotransmitters with triple reuptake inhibitors in the treatment of conditions affected by monoamine neurotransmitters.
    Type: Application
    Filed: July 30, 2020
    Publication date: February 18, 2021
    Inventors: Anthony McKinney, Frank Bymaster
  • Publication number: 20190358199
    Abstract: The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable active salts, polymorphs, glycosylated derivatives, metabolites, solvates, hydrates, and/or prodrugs of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and their use alone or in combination with additional psychotherapeutic compositions in the treatment of conditions affected by monoamine neurotransmitters, including treatment of refractory individuals.
    Type: Application
    Filed: December 28, 2018
    Publication date: November 28, 2019
    Inventors: Anthony Alexander McKinney, Frank Bymaster, Walter Piskorski
  • Publication number: 20180256542
    Abstract: The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable active salts, polymorphs, glycosylated derivatives, metabolites, solvates, hydrates, and/or prodrugs of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and their use alone or in combination with additional psychotherapeutic compositions in the treatment of conditions affected by monoamine neurotransmitters, including treatment of refractory individuals.
    Type: Application
    Filed: October 13, 2017
    Publication date: September 13, 2018
    Inventors: Anthony Alexander McKinney, Frank Bymaster, Walter Piskorski
  • Publication number: 20180215710
    Abstract: The present invention relates to methods of inhibiting native and promiscuous uptake of biogenic amine neurotransmitters with triple reuptake inhibitors in the treatment of conditions affected by monoamine neurotransmitters.
    Type: Application
    Filed: September 8, 2017
    Publication date: August 2, 2018
    Inventors: Anthony McKinney, Frank Bymaster
  • Patent number: 9566264
    Abstract: The present disclosure relates to novel methods of treating pain comprising administering to a human in need thereof an effective amount of (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, in free and/or pharmaceutically acceptable salt form, substantially free of the corresponding (?) enantiomer, wherein the human is a heavy drinker and/or binge drinker and/or wherein the human has compromised liver function and/or wherein the human is a codeine non-responder. The present disclosure also relates to a method of treating pain comprising concurrently or sequentially administering to a patient in need thereof an effective amount of (a) (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, in free and/or pharmaceutically acceptable salt form, and (b) acetaminophen. The present disclosure also relates to a method of treating pain comprising simultaneously or sequentially administering to a patient in need thereof an effective amount of (a) (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: February 14, 2017
    Assignee: EUTHYMICS BIOSCIENCE, INC.
    Inventors: Frank Bymaster, Anthony McKinney
  • Publication number: 20160346249
    Abstract: The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable active salts, polymorphs, glycosylated derivatives, metabolites, solvates, hydrates, and/or prodrugs of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and their use alone or in combination with additional psychotherapeutic compositions in the treatment of conditions affected by monoamine neurotransmitters, including treatment of refractory individuals. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane compositions are metabolized by either or both MAO-A or cytochrome P450 enzymes and thus are effective in the treatment of individuals with cytochrome P450 polymorphisms or who are taking other medications that affect the cytochrome P450 pathway.
    Type: Application
    Filed: August 9, 2013
    Publication date: December 1, 2016
    Inventors: Anthony Alexander McKinney, Frank Bymaster, Richard Welter, Randall Marshall
  • Publication number: 20160199347
    Abstract: The present invention relates to methods of inhibiting native and promiscuous uptake of biogenic amine neurotransmitters with triple reuptake inhibitors in the treatment of conditions affected by monoamine neurotransmitters.
    Type: Application
    Filed: September 14, 2015
    Publication date: July 14, 2016
    Inventors: Anthony McKinney, Frank Bymaster
  • Publication number: 20140228421
    Abstract: The present invention relates to methods of inhibiting native and promiscuous uptake of biogenic amine neurotransmitters with triple reuptake inhibitors in the treatment of conditions affected by monoamine neurotransmitters.
    Type: Application
    Filed: June 2, 2013
    Publication date: August 14, 2014
    Inventors: Anthony McKinney, Frank Bymaster
  • Publication number: 20140206740
    Abstract: The present invention relates to (1R,5S)-(+)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane and pharmaceutical compositions thereof, and methods employing their use in the treatment of conditions affected by monoamine neurotransmitters, including ADHD and substance abuse.
    Type: Application
    Filed: June 2, 2013
    Publication date: July 24, 2014
    Applicant: Neurovance, Inc.
    Inventors: Anthony Alexander McKINNEY, Frank Bymaster
  • Publication number: 20140039029
    Abstract: The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable active salts, polymorphs, glycosylated derivatives, metabolites, solvates, hydrates, and/or prodrugs of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and their use alone or in combination with additional psychotherapeutic compositions in the treatment of conditions affected by monoamine neurotransmitters, including treatment of refractory individuals.
    Type: Application
    Filed: June 20, 2013
    Publication date: February 6, 2014
    Inventors: Anthony Alexander McKinney, Frank Bymaster, Walter Piskorski
  • Publication number: 20130123238
    Abstract: The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof, compositions comprising (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and methods for treating or preventing an alcohol-related or addictive disorder. The (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.
    Type: Application
    Filed: July 13, 2012
    Publication date: May 16, 2013
    Inventors: Anthony Alexander McKinney, Frank Bymaster
  • Publication number: 20120258994
    Abstract: The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable active salts, polymorphs, glycosylated derivatives, metabolites, solvates, hydrates, and/or prodrugs of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and their use alone or in combination with additional psychotherapeutic compositions in the treatment of conditions affected by monoamine neurotransmitters, including treatment of refractory individuals.
    Type: Application
    Filed: December 2, 2011
    Publication date: October 11, 2012
    Inventors: Anthony Alexander McKINNEY, Frank Bymaster, Walter Piskorski