Patents by Inventor Frank C. Grenier

Frank C. Grenier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition and method for the diagnosis and treatment of iron-related disorders
    Patent number: 9636398
    Abstract: Provided herein are antibodies and methods of using the antibodies to treat, prevent, modulate, attenuate and diagnose iron-related disorders.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: May 2, 2017
    Assignees: ABBVIE DEUTSCHLAND GMBH & CO. KG, ABBVIE INC.
    Inventors: Gangamani S. Beligere, Shamila Manoj, Elaine M. Brate, Frank C. Grenier, David J. Hawksworth, Robert N. Ziemann, Larry G. Birkenmeyer, Bernhard Mueller, Andreas Popp, Susan Brophy
  • Antibodies that bind to mammalian NGAL and uses thereof
    Patent number: 8846036
    Abstract: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: September 30, 2014
    Assignee: Abbott Laboratories
    Inventors: Larry G. Birkenmeyer, Suresh M. Desai, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Robert N. Ziemann, Frank C. Grenier, Ryan F. Workman, Lowell Tyner
  • Non-denaturing lysis reagent
    Patent number: 8697365
    Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and an alcohol. Other aspects of the invention include related immunoassays and test kits.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: April 15, 2014
    Assignee: Abbott Laboratories
    Inventors: Frank C. Grenier, Ryan F. Workman, Hina N. Syed, Salman Ali
  • Immunosuppressant drug extraction reagent for immunoassays
    Patent number: 8541554
    Abstract: An improved extractive reagent composition and method for extracting an immunosuppressant drug, such as sirolimus, tacrolimus or cyclosporine, from blood samples while yielding a test sample extract that has low vapor pressure and is compatible with immunoassay components. The inventive reagent composition comprises dimethyl sulfoxide (DMSO), at least one divalent metal salt and water. The sample extracts resulting from use of each of these combinations have low vapor pressure and are compatible with immunochemistry assays.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: September 24, 2013
    Assignee: Abbott Laboratories
    Inventors: Frank C. Grenier, Ryan F. Workman, Hina Syed, Salman Ali
  • Diagnostic test for the detection of a molecule or drug in whole blood
    Patent number: 8440416
    Abstract: The invention provides methods of preparing a test sample for use in an assay for detecting an analyte bound by an intracellular ligand. The methods typically involve contacting the test sample with an assay reagent comprising: a lysis reagent; and a protease that has proteolytic activity for said intracellular ligand; to form a mixture compatible for use in an immunoassay without subsequent extraction steps. Other aspects of the invention include related immunoassays and test kits.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: May 14, 2013
    Assignee: Abbott Laboratories
    Inventors: Frank C. Grenier, Ryan F. Workman, Hina N. Syed, Salman Ali
  • Neutrophil gelatinase-associated lipocalin (NGAL) protein isoforms enriched from urine and recombinant chinese hamster ovary (CHO) cells and related compositions, antibodies, and methods of enrichment, analysis and use
    Patent number: 8394606
    Abstract: A composition comprising neutrophil gelatinase-associated lipocalin (NGAL), which has been enriched from urine, has a molecular weight of about 24.9 kDa to about 25.9 kDa, and comprises a plurality of isoforms having isoelectric points (pIs) ranging from about 5.9 to about 9.1; a composition comprising NGAL, which has been enriched from recombinant Chinese hamster ovary (CHO) cells, has a molecular weight of about 25.9 kDa to about 27.9 kDa, and comprises a plurality of isoforms having pIs ranging from about 5.6 to about 9.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: March 12, 2013
    Assignee: Abbott Laboratories
    Inventors: Salman Ali, Ryan M. Bonn, Frank C. Grenier, Tracey D. Rae, Kevin R. Rupprecht, Hina N. Syed, Bailin Tu, Joan D. Tyner, Ryan F. Workman
  • Diagnostic Test For The Detection Of A Molecule Or Drug In Whole Blood
    Publication number: 20120288875
    Abstract: The invention provides methods of preparing a test sample for use in an assay for detecting an analyte bound by an intracellular ligand. The methods typically involve contacting the test sample with an assay reagent comprising: a lysis reagent; and a protease that has proteolytic activity for said intracellular ligand; to form a mixture compatible for use in an immunoassay without subsequent extraction steps. Other aspects of the invention include related immunoassays and test kits.
    Type: Application
    Filed: July 12, 2012
    Publication date: November 15, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Frank C. Grenier, Ryan F. Workman, Hina N. Syed, Salman Ali
  • Diagnostic test for the detection of a molecule or drug in whole blood
    Patent number: 8221986
    Abstract: The invention provides methods of preparing a test sample for use in an assay for detecting an analyte bound by an intracellular ligand. The methods typically involve contacting the test sample with an assay reagent comprising: a lysis reagent; and a protease that has proteolytic activity for said intracellular ligand; to form a mixture compatible for use in an immunoassay without subsequent extraction steps. Other aspects of the invention include related immunoassays and test kits.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: July 17, 2012
    Assignee: Abbott Laboratories
    Inventors: Frank C. Grenier, Ryan F. Workman, Hina N. Syed, Salman Ali
  • NON-DENATURING LYSIS REAGENT
    Publication number: 20110171662
    Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and an alcohol. Other aspects of the invention include related immunoassays and test kits.
    Type: Application
    Filed: March 24, 2011
    Publication date: July 14, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Frank C. Grenier, Ryan F. Workman, Hina N. Syed, Salman Ali
  • IMMUNOSUPPRESSANT DRUG EXTRACTION REAGENT FOR IMMUNOASSAYS
    Publication number: 20110091997
    Abstract: An improved extractive reagent composition and method for extracting an immunosuppressant drug, such as sirolimus, tacrolimus or cyclosporine, from blood samples while yielding a test sample extract that has low vapor pressure and is compatible with immunoassay components. The inventive reagent composition comprises dimethyl sulfoxide (DMSO), at least one divalent metal salt and water. The sample extracts resulting from use of each of these combinations have low vapor pressure and are compatible with immunochemistry assays.
    Type: Application
    Filed: December 29, 2010
    Publication date: April 21, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: FRANK C. GRENIER, RYAN F. WORKMAN, HINA SYED, SALMAN ALI
  • Non-denaturing lysis reagent
    Patent number: 7914999
    Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and an alcohol. Other aspects of the invention include related immunoassays and test kits.
    Type: Grant
    Filed: December 29, 2006
    Date of Patent: March 29, 2011
    Assignee: Abbott Laboratories
    Inventors: Frank C. Grenier, Ryan F. Workman, Hina N. Syed, Salman Ali
  • Immunosuppressant drug extraction reagent for immunoassays
    Patent number: 7883855
    Abstract: An improved extractive reagent composition and method for extracting an immunosuppressant drug, such as sirolimus, tacrolimus or cyclosporine, from blood samples while yielding a test sample extract that has low vapor pressure and is compatible with immunoassay components. The inventive reagent composition comprises dimethyl sulfoxide (DMSO), at least one divalent metal salt and water. The sample extracts resulting from use of each of these combinations have low vapor pressure and are compatible with immunochemistry assays.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: February 8, 2011
    Assignee: Abbott Laboratories
    Inventors: Frank C. Grenier, Ryan F. Workman, Hina Syed, Salman Ali
  • Dual Variable Domain Immunoglobulins and Uses Thereof
    Publication number: 20110008766
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: April 30, 2010
    Publication date: January 13, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Tariq Ghayur, Junjian Liu, Susan E. Brophy, Sushil G. Devare, Frank C. Grenier, Jeffrey A. Moore, Qiaoqiao Ruan, Sergey Y. Tetin, Jennifer M. Steinhaus, Salman Ali, Hina N. Syed
  • IMMUNOASSAYS AND KITS FOR THE DETECTION OF NGAL
    Publication number: 20100227775
    Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
    Type: Application
    Filed: May 21, 2010
    Publication date: September 9, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Larry G. Birkenmeyer, Suresh M. Desai, Frank C. Grenier, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Ryan F. Workman, Robert N. Ziemann
  • NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) PROTEIN ISOFORMS ENRICHED FROM URINE AND RECOMBINANT CHINESE HAMSTER OVARY (CHO) CELLS AND RELATED COMPOSITIONS, ANTIBODIES, AND METHODS OF ENRICHMENT, ANALYSIS AND USE
    Publication number: 20100116662
    Abstract: A composition comprising neutrophil gelatinase-associated lipocalin (NGAL), which has been enriched from urine, has a molecular weight of about 24.9 kDa to about 25.9 kDa, and comprises a plurality of isoforms having isoelectric points (pIs) ranging from about 5.9 to about 9.1; a composition comprising NGAL, which has been enriched from recombinant Chinese hamster ovary (CHO) cells, has a molecular weight of about 25.9 kDa to about 27.9 kDa, and comprises a plurality of isoforms having pIs ranging from about 5.6 to about 9.
    Type: Application
    Filed: November 4, 2009
    Publication date: May 13, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Salman Ali, Ryan M. Bonn, Frank C. Grenier, Tracey D. Rae, Kevin R. Rupprecht, Hina N. Syed, Bailin Tu, Joan D. Tyner, Ryan F. Workman
  • Diagnostic Test For The Detection Of A Molecule Or Drug In Whole Blood
    Publication number: 20090325193
    Abstract: The invention provides methods of preparing a test sample for use in an assay for detecting an analyte bound by an intracellular ligand. The methods typically involve contacting the test sample with an assay reagent comprising: a lysis reagent; and a protease that has proteolytic activity for said intracellular ligand; to form a mixture compatible for use in an immunoassay without subsequent extraction steps. Other aspects of the invention include related immunoassays and test kits.
    Type: Application
    Filed: June 25, 2009
    Publication date: December 31, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Frank C. Grenier, Ryan F. Workman, Hina N. Syed, Salman Ali
  • IMMUNOASSAYS AND KITS FOR THE DETECTION OF NGAL
    Publication number: 20090269777
    Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
    Type: Application
    Filed: April 16, 2008
    Publication date: October 29, 2009
    Applicant: Abbott Laboratories
    Inventors: Larry G. Birkenmeyer, Suresh M. Desai, Frank C. Grenier, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Lowell J. Tyner, Ryan F. Workman, Robert N. Ziemann
  • IMMUNOASSAYS AND KITS FOR THE DETECTION OF NGAL
    Publication number: 20090123946
    Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
    Type: Application
    Filed: December 5, 2008
    Publication date: May 14, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Larry G. Birkenmeyer, Suresh M. Desai, Frank C. Grenier, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Ryan F. Workman, Robert N. Ziemann, Lowell J. Tyner
  • NON-DENATURING LYSIS REAGENT
    Publication number: 20080160499
    Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and an alcohol. Other aspects of the invention include related immunoassays and test kits.
    Type: Application
    Filed: December 29, 2006
    Publication date: July 3, 2008
    Inventors: Frank C. Grenier, Ryan F. Workman, Hina N. Syed, Salman Ali
  • Immunosuppressant drug extraction reagent for immunoassays
    Publication number: 20080020401
    Abstract: An improved extractive reagent composition and method for extracting an immunosuppressant drug, such as sirolimus, tacrolimus or cyclosporine, from blood samples while yielding a test sample extract that has low vapor pressure and is compatible with immunoassay components. The inventive reagent composition comprises dimethyl sulfoxide (DMSO), at least one divalent metal salt and water. The sample extracts resulting from use of each of these combinations have low vapor pressure and are compatible with immunochemistry assays.
    Type: Application
    Filed: July 21, 2006
    Publication date: January 24, 2008
    Inventors: Frank C. Grenier, Ryan F. Workman, Hina Syed, Salman Ali